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Published in Angewandte Chemie International Edition (03.01.2014)
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Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
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Published in Cancer research (Chicago, Ill.) (01.05.2008)
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Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor
Jang, Jaebong, Son, Jieun, Park, Eunyoung, Kosaka, Takayuki, Saxon, Jamie A., De Clercq, Dries J. H., Choi, Hwan Geun, Tanizaki, Junko, Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Published in Angewandte Chemie (International ed.) (03.09.2018)
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EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors
Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Clinical cancer research (01.09.2015)
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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.
Published in Cell chemical biology (18.01.2018)
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Structural Basis of AZD9291 Selectivity for EGFR T790M
Yan, Xiao-E, Ayaz, Pelin, Zhu, Su-Jie, Zhao, Peng, Liang, Ling, Zhang, Casey H, Wu, Ya-Chuang, Li, Je-Luen, Choi, Hwan Geun, Huang, Xin, Shan, Yibing, Shaw, David E, Yun, Cai-Hong
Published in Journal of medicinal chemistry (13.08.2020)
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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
Hunter, John C., Gurbania, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.
Published in Proceedings of the National Academy of Sciences - PNAS (17.06.2014)
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Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett, Mathew J., Edelman, Elena J., Heidorn, Sonja J., Greenman, Chris D., Dastur, Anahita, Lau, King Wai, Greninger, Patricia, Thompson, I. Richard, Luo, Xi, Soares, Jorge, Liu, Qingsong, Iorio, Francesco, Surdez, Didier, Chen, Li, Milano, Randy J., Bignell, Graham R., Tam, Ah T., Davies, Helen, Stevenson, Jesse A., Barthorpe, Syd, Lutz, Stephen R., Kogera, Fiona, Lawrence, Karl, McLaren-Douglas, Anne, Mitropoulos, Xeni, Mironenko, Tatiana, Thi, Helen, Richardson, Laura, Zhou, Wenjun, Jewitt, Frances, Zhang, Tinghu, O’Brien, Patrick, Boisvert, Jessica L., Price, Stacey, Hur, Wooyoung, Yang, Wanjuan, Deng, Xianming, Butler, Adam, Choi, Hwan Geun, Chang, Jae Won, Baselga, Jose, Stamenkovic, Ivan, Engelman, Jeffrey A., Sharma, Sreenath V., Delattre, Olivier, Saez-Rodriguez, Julio, Gray, Nathanael S., Settleman, Jeffrey, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Ramaswamy, Sridhar, McDermott, Ultan, Benes, Cyril H.
Published in Nature (London) (29.03.2012)
Published in Nature (London) (29.03.2012)
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KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice
Dorotea, Debra, Lee, Seungyeon, Lee, Sun Joo, Lee, Gayoung, Son, Jung Beom, Choi, Hwan Geun, Ahn, Sung-Min, Ha, Hunjoo
Published in Biomolecules & therapeutics (01.01.2021)
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Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
Clark, Kristopher, MacKenzie, Kirsty F, Petkevicius, Kasparas, Kristariyanto, Yosua, Zhang, Jiazhen, Choi, Hwan Geun, Peggie, Mark, Plater, Lorna, Pedrioli, Patrick G. A, McIver, Ed, Gray, Nathanael S, Arthur, J. Simon C, Cohen, Philip
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer
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Published in Clinical cancer research (01.07.2008)
Published in Clinical cancer research (01.07.2008)
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Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
Dorotea, Debra, Jiang, Songling, Pak, Eun Seon, Son, Jung Beom, Choi, Hwan Geun, Ahn, Sung-Min, Ha, Hunjoo
Published in Experimental & molecular medicine (01.08.2022)
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GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
Reith, Alastair D., Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R., Gray, Nathanael S.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma
Miao, Benchun, Ji, Zhenyu, Tan, Li, Taylor, Michael, Zhang, Jianming, Choi, Hwan Geun, Frederick, Dennie T, Kumar, Raj, Wargo, Jennifer A, Flaherty, Keith T, Gray, Nathanael S, Tsao, Hensin
Published in Cancer discovery (01.03.2015)
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Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage
Bae, Yun-Hee, Joo, Hyejin, Bae, Jinhyun, Hyeon, Seung Jae, Her, Song, Ko, Eunhwa, Choi, Hwan Geun, Ryu, Hoon, Hur, Eun-Mi, Bu, Youngmin, Lee, Byoung Dae
Published in Cell death & disease (12.11.2018)
Published in Cell death & disease (12.11.2018)
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Characterization of TAE684 as a potent LRRK2 kinase inhibitor
Zhang, Jinwei, Deng, Xianming, Choi, Hwan Geun, Alessi, Dario R., Gray, Nathanael S.
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin
Mujahid, Nisma, Liang, Yanke, Murakami, Ryo, Choi, Hwan Geun, Dobry, Allison S., Wang, Jinhua, Suita, Yusuke, Weng, Qing Yu, Allouche, Jennifer, Kemeny, Lajos V., Hermann, Andrea L., Roider, Elisabeth M., Gray, Nathanael S., Fisher, David E.
Published in Cell reports (Cambridge) (13.06.2017)
Published in Cell reports (Cambridge) (13.06.2017)
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Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
Kim, Hyung-Gu, Tan, Li, Weisberg, Ellen L, Liu, Feiyang, Canning, Peter, Choi, Hwan Geun, Ezell, Scott A, Wu, Hong, Zhao, Zheng, Wang, Jinhua, Mandinova, Anna, Griffin, James D, Bullock, Alex N, Liu, Qingsong, Lee, Sam W, Gray, Nathanael S
Published in ACS chemical biology (18.10.2013)
Published in ACS chemical biology (18.10.2013)
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Structural basis of mutant-selectivity and drug-resistance related to CO-1686
Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong
Published in Oncotarget (08.08.2017)
Published in Oncotarget (08.08.2017)
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Sundberg, Thomas B., Choi, Hwan Geun, Song, Joo-Hye, Russell, Caitlin N., Hussain, Mahmud M., Graham, Daniel B., Khor, Bernard, Gagnon, John, O'Connell, Daniel J., Narayan, Kavitha, Dančik, Vlado, Perez, Jose R., Reinecker, Hans-Christian, Gray, Nathanael S., Schreiber, Stuart L., Xavier, Ramnik J., Shamji, Alykhan F.
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
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