Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M., Yoon, Woo H., Whelan, Kevin, Sanabria, Erin K., Grottick, Andrew J., Al-Shamma, Hussien, Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R, Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I, Casper, Martin D, Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R, Connolly, Daniel T, Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2A Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
XIONG YIFENG, JONES ROBERT M, UNETT DAVID J, JAYAKUMAR HONNAPPA, CHOI JIN SUN KAROLINE, DOSA PETER I, FEICHTINGER KONRAD, CASPER MARTIN, LEHMANN JUERG, TEEGARDEN BRADLEY, STRAH PLEYNET SONJA
Year of Publication 14.03.2013
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Year of Publication 14.03.2013
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1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA
DAVE VIBHA, XIONG YIFENG, JONES ROBERT M, UY JANE, AZIMIOARA MIHAI D, PEREIRA GUILHERME, CALDERON IMELDA, DUVVURI KAMESHWARI, CHOI JIN SUN KAROLINE, FIORAVANTI BEATRIZ, SEMPLE GRAEME
Year of Publication 07.02.2011
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Year of Publication 07.02.2011
Patent
Discovery and Structure-Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine(2A) Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine(2A) Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I., Feichtinger, Konrad, Teegarden, Bradley R., Frazer, John M., Yoon, Woo H., Shan, Yun, Whelan, Kevin, Hauser, Erin K., Grottick, Andrew J., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
Get full text
Journal Article
Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine 2A Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I., Feichtinger, Konrad, Teegarden, Bradley R., Frazer, John M., Yoon, Woo H., Shan, Yun, Whelan, Kevin, Hauser, Erin K., Grottick, Andrew J., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
Get full text
Journal Article
Discovery and Structure−Activity Relationship of 3-Methoxy- N -(3-(1-methyl-1 H -pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine 2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M, Yoon, Woo H, Whelan, Kevin, Sanabria, Erin K, Grottick, Andrew J, Al-Shamma, Hussien, Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Journal Article
3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Xiong, Yifeng, Strah-Pleynet, Sonja, Unett, David J, Feichtinger, Konrad, Jones, Robert M, Dosa, Peter I, Teegarden, Bradley, Jayakumar, Honnappa, Casper, Martin, Lehmann, Juerg, Choi, Jin Sun Karoline
Year of Publication 22.09.2020
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Year of Publication 22.09.2020
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
ULLMAN, Brett, CHOI, Jin Sun Karoline, TEEGARDEN, Bradley, SMITH, Brian M, DOSA, Peter I, XIONG, Yifeng, STRAH-PLEYNET, Sonja, CHERRIER, Martin C
Year of Publication 13.02.2020
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Year of Publication 13.02.2020
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3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Xiong, Yifeng, Strah-Pleynet, Sonja, Unett, David J, Feichtinger, Konrad, Jones, Robert M, Dosa, Peter I, Teegarden, Bradley, Jayakumar, Honnappa, Casper, Martin, Lehmann, Juerg, Choi, Jin Sun Karoline
Year of Publication 29.08.2019
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Year of Publication 29.08.2019
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Xiong, Yifeng, Strah-Pleynet, Sonja, Dosa, Peter I, Teegarden, Bradley, Smith, Brian M, Ullman, Brett, Cherrier, Martin C, Choi, Jin Sun Karoline
Year of Publication 16.07.2019
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Year of Publication 16.07.2019
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
STRAH-PLEYNET, SONJA, SMITH, BRIAN M, XIONG, YIFENG, ULLMAN, BRETT, DOSA, PETER I, CHERRIER, MARTIN C, CHOI, JIN SUN KAROLINE, TEEGARDEN, BRADLEY
Year of Publication 13.03.2018
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Year of Publication 13.03.2018
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 09.11.2017
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Year of Publication 09.11.2017
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 15.08.2017
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Year of Publication 15.08.2017
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3-fenylpyrazol derivater, farmasøytiske sammensetninger inneholdende slike, fremgangsmåte for fremstilling og anvendelse som modulatorer av 5HT2A serotoninreseptoren for behandling av forstyrrelser relatert dertil
Xiong, Yifeng, Strah-Pleynet, Sonja, Unett, David J, Feichtinger, Konrad, Jones, Robert M, Dosa, Peter I, Teegarden, Bradley, Jayakumar, Honnappa, Casper, Martin, Choi, Jin Sun Karoline, Lehmann, Juerg
Year of Publication 22.05.2017
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Year of Publication 22.05.2017
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3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Jayakumar Honnappa, Teegarden Bradley, Feichtinger Konrad, Unett David J, Strah-Pleynet Sonja, Lehmann Juerg, Jones Robert M, Choi Jin Sun Karoline, Dosa Peter I, Xiong Yifeng, Casper Martin
Year of Publication 20.10.2016
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Year of Publication 20.10.2016
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 06.09.2016
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Year of Publication 06.09.2016
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