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Published in Drug metabolism and disposition (01.11.2004)
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Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites
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Design and Biological Activities of L-163,191 (MK-0677): A Potent, Orally Active Growth Hormone Secretagogue
Patchett, A. A., Nargund, R. P., Tata, J. R., M.-H. Chen, Barakat, K. J., Johnston, D. B. R., Cheng, K., W. W.-S. CHan, Butler, B., Hickey, G., Jacks, T., Schleim, K., S.-S. Pong, L.-Y. P. Chaung, Chen, H. Y., Frazier, E., Leung, K. H., S.-H. L. Chiu, Smith, Roy G.
Published in Proceedings of the National Academy of Sciences - PNAS (18.07.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (18.07.1995)
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Dorn, Conrad P, Finke, Paul E, Budhu, Richard J, Reamer, Robert A, Huskey, Su-Er W, Luffer-Atlas, Debra, Dean, Brian J, McGowan, Erin M, Feeney, William P, Chiu, Shuet-Hing Lee, Cascieri, Margaret A, Chicchi, Gary G, Kurtz, Marc M, Sadowski, Sharon, Ber, Elzbieta, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, Metzger, Joseph M, MacIntyre, D. Euan
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Published in Journal of medicinal chemistry (23.03.2000)
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THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS
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Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein
Kumar, Sanjeev, Kwei, Gloria Y, Poon, Grace K, Iliff, Susan A, Wang, Yanfeng, Chen, Qing, Franklin, Ronald B, Didolkar, Varsha, Wang, Regina W, Yamazaki, Masayo, Chiu, Shuet-Hing Lee, Lin, Jiunn H, Pearson, Paul G, Baillie, Thomas A
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METABOLISM AND PHARMACOKINETICS OF A DIPEPTIDYL PEPTIDASE IV INHIBITOR IN RATS, DOGS, AND MONKEYS WITH SELECTIVE CARBAMOYL GLUCURONIDATION OF THE PRIMARY AMINE IN DOGS
BECONI, Maria G, MAO, Ann, LIU, David Q, KOCHANSKY, Christopher, PEREIRA, Tony, RAAB, Conrad, PEARSON, Paul, LEE CHIU, Shuet-Hing
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In vitro and in vivo trans-esterification of 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3(S)-benzyl-piperidine-3-carboxylic acid ethyl ester and the effects of ethanol on its pharmacokinetics in rats
Chen, Zhesheng, Agrawal, Arun K, Franklin, Ronald B, Leung, Kwan H, Chiu, Shuet-Hing Lee
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1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): A potent, orally bioavailable, and short-duration growth hormone secretagogue
Yang, LH, Morriello, G, Patchett, AA, Leung, K, Jacks, T, Cheng, K, Schleim, KD, Feeney, W, Chan, WWS, Chiu, SHL, Smith, RG
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Published in Journal of medicinal chemistry (02.07.1998)
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Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on-line simultaneous quantification of a drug candidate and its six metabolites in dog plasma
Xia, Yuan-Qing, Hop, Cornelis E.C.A., Liu, David Q., Vincent, Stella H., Chiu, Shuet-Hing L.
Published in Rapid communications in mass spectrometry (01.01.2001)
Published in Rapid communications in mass spectrometry (01.01.2001)
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1-(((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2.2.1]-HEPTAN-1(S)-YL)METHYL)SULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE (L-368,899) - AN ORALLY BIOAVAILABLE, NONPEPTIDE OXYTOCIN ANTAGONIST WITH POTENTIAL UTILITY FOR MANAGING PRETERM LABOR
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Published in Journal of medicinal chemistry (04.03.1994)
Published in Journal of medicinal chemistry (04.03.1994)
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A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue
DeVita, Robert J, Bochis, Richard, Frontier, Alison J, Kotliar, Andrew, Fisher, Michael H, Schoen, William R, Wyvratt, Matthew J, Cheng, Kang, Chan, Wanda W.-S, Butler, Bridget, Jacks, Thomas M, Hickey, Gerard J, Schleim, Klaus D, Leung, Kwan, Chen, Zhesheng, Chiu, S.-H. Lee, Feeney, William P, Cunningham, Paul K, Smith, Roy G
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene
Leung, Kwan H., Yao, Ming, Stearns, Ralph, Chiu, Shuet-Hing Lee
Published in Chemico-biological interactions (30.06.1995)
Published in Chemico-biological interactions (30.06.1995)
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Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma
HOP, Cornelis E. C. A, YANFENG WANG, CURTIS, Neil, ELLIOTT, Jason, GERHARD, Ute, LOCKER, Karen, MORRISON, Denise, MORTISHIRE-SMITH, Russell, THOMAS, Steven, WATT, Alan P, EVANS, David C, KUMAR, Sanjeev, SILVA ELIPE, Maria Victoria, RAAB, Conrad E, DEAN, Dennis C, POON, Grace K, KEOHANE, Carol-Ann, STRAUSS, John, CHIU, Shuet-Hing L
Published in Drug metabolism and disposition (01.08.2002)
Published in Drug metabolism and disposition (01.08.2002)
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BRAIN PENETRATION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN FERRETS
HUSKEY, Su-Er W, DEAN, Brian J, HORA, Donald F, CHIU, Shuet-Hing L, BAKHTIAR, Ray, SANCHEZ, Rosa I, TATTERSALL, F. David, RYCROFT, Wayne, HARGREAVES, Richard, WATT, Alan P, CHICCHI, Gary G, KEOHANE, Carolann
Published in Drug metabolism and disposition (01.06.2003)
Published in Drug metabolism and disposition (01.06.2003)
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