Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial
Metz, Martin, Sussman, Gordon, Gagnon, Rémi, Staubach, Petra, Tanus, Tonny, Yang, William H., Lim, Jeremy J., Clarke, Holly J., Galanter, Joshua, Chinn, Leslie W., Chu, Tom, Teterina, Anastasia, Burgess, Tracy, Haddon, D. James, Lu, Timothy T., Maurer, Marcus
Published in Nature medicine (01.11.2021)
Published in Nature medicine (01.11.2021)
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Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI
Jones, Nicholas S., Yoshida, Kenta, Salphati, Laurent, Kenny, Jane R., Durk, Matthew R., Chinn, Leslie W.
Published in Clinical pharmacology and therapeutics (01.01.2020)
Published in Clinical pharmacology and therapeutics (01.01.2020)
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Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions
Chen, Yuan, Ma, Fang, Jones, Nicholas S., Yoshida, Kenta, Chiang, Po‐Chang, Durk, Matthew R., Wright, Matthew R., Jin, Jin Yan, Chinn, Leslie W.
Published in CPT: pharmacometrics and systems pharmacology (01.06.2020)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2020)
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Journal Article
The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene
Abla, Nada, Chinn, Leslie W, Nakamura, Tsutomu, Liu, Li, Huang, Conrad C, Johns, Susan J, Kawamoto, Michiko, Stryke, Doug, Taylor, Travis R, Ferrin, Thomas E, Giacomini, Kathleen M, Kroetz, Deanna L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2008)
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Journal Article
Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms
Gow, Jason M, Hodges, Laura M, Chinn, Leslie W, Kroetz, Deanna L
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)
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Journal Article
Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection
Chinn, Leslie W., Tang, Minzhong, Kessing, Bailey D., Lautenberger, James A., Troyer, Jennifer L., Malasky, Michael J., McIntosh, Carl, Kirk, Gregory D., Wolinsky, Steven M., Buchbinder, Susan P., Gomperts, Edward D., Goedert, James J., O'Brien, Stephen J.
Published in The Journal of infectious diseases (15.12.2010)
Published in The Journal of infectious diseases (15.12.2010)
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Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans
Baruch, Amos, Wong, Chin, Chinn, Leslie W., Vaze, Anjali, Sonoda, Junichiro, Gelzleichter, Thomas, Chen, Shan, Lewin-Koh, Nicholas, Morrow, Linda, Dheerendra, Suresh, Boismenu, Richard, Gutierrez, Johnny, Wakshull, Eric, Wilson, Maria E., Arora, Puneet S.
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
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Efficacy, Safety, and Pharmacodynamic Effects of the Bruton’s Tyrosine Kinase Inhibitor Fenebrutinib (GDC‐0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double‐Blind, Placebo‐Controlled Trial
Isenberg, David, Furie, Richard, Jones, Nicholas S., Guibord, Pascal, Galanter, Joshua, Lee, Chin, McGregor, Anna, Toth, Balazs, Rae, Julie, Hwang, Olivia, Desai, Rupal, Lokku, Armend, Ramamoorthi, Nandhini, Hackney, Jason A., Miranda, Pedro, Souza, Viviane A., Jaller‐Raad, Juan J., Maura Fernandes, Anna, Garcia Salinas, Rodrigo, Chinn, Leslie W., Townsend, Michael J., Morimoto, Alyssa M., Tuckwell, Katie
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2021)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2021)
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Journal Article
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)
Hodges, Laura M, Markova, Svetlana M, Chinn, Leslie W, Gow, Jason M, Kroetz, Deanna L, Klein, Teri E, Altman, Russ B
Published in Pharmacogenetics and genomics (01.03.2011)
Published in Pharmacogenetics and genomics (01.03.2011)
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Journal Article
Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC-0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor
Herman, Ann E, Chinn, Leslie W, Kotwal, Shweta G, Murray, Elaine R, Zhao, Rui, Florero, Marilyn, Lin, Alyse, Moein, Anita, Wang, Rena, Bremer, Meire, Kokubu, Serika, Serone, Adrian P, Hanze, Eva L, Viberg, Anders, Morimoto, Alyssa M, Winter, Helen R, Katsumoto, Tamiko R
Published in Clinical pharmacology and therapeutics (01.06.2018)
Published in Clinical pharmacology and therapeutics (01.06.2018)
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Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults
Byakika-Tusiime, Jayne, Chinn, Leslie W, Oyugi, Jessica H, Obua, Celestino, Bangsberg, David R, Kroetz, Deanna L
Published in PloS one (19.12.2008)
Published in PloS one (19.12.2008)
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Journal Article
Absence of Pharmacokinetic Interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate
Jones, Nicholas Steven, Winter, Helen, Katsumoto, Tamiko R, Florero, Marilyn, Murray, Elaine, Walker, Helen, Singh, Nand, Chinn, Leslie W
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Journal Article
Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study
Durk, Matthew R., Jones, Nicholas S., Liu, Jia, Nagapudi, Karthik, Mao, Chen, Plise, Emile G., Wong, Susan, Chen, Jacob Z., Chen, Yuan, Chinn, Leslie W., Chiang, Po‐Chang
Published in Clinical pharmacology and therapeutics (01.12.2020)
Published in Clinical pharmacology and therapeutics (01.12.2020)
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Journal Article
PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network
Nguyen, Tan D, Gow, Jason M, Chinn, Leslie W, Kelly, Libusha, Jeong, Hotcherl, Huang, Conrad C, Stryke, Doug, Kawamoto, Michiko, Johns, Susan J, Carlson, Elaine, Taylor, Travis, Ferrin, Thomas E, Sali, Andrej, Giacomini, Kathleen M, Kroetz, Deanna L
Published in Pharmacological reviews (01.03.2006)
Published in Pharmacological reviews (01.03.2006)
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Journal Article
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
Micheli, Janine E, Chinn, Leslie W, Shugarts, Sarah B, Patel, Ashish, Martin, Jeffrey N, Bangsberg, David R, Kroetz, Deanna L
Published in Pharmacogenetics and genomics (01.11.2013)
Published in Pharmacogenetics and genomics (01.11.2013)
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Functional hot spots in human ATP‐binding cassette transporter nucleotide binding domains
Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M., Chinn, Leslie W., Pieper, Ursula, Segal, Mark R., Kroetz, Deanna L., Sali, Andrej
Published in Protein science (01.11.2010)
Published in Protein science (01.11.2010)
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Journal Article
Response to “Predictable difficulty or difficulty to predict”
Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M., Chinn, Leslie W., Pieper, Ursula, Segal, Mark R., Kroetz, Deanna L., Sali, Andrej
Published in Protein science (01.01.2011)
Published in Protein science (01.01.2011)
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Journal Article
Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double‐Blind, Phase II Trial
Cohen, Stanley, Zhao, Rui, Toth, Balazs, Hackney, Jason A., Berman, Alberto, Chinn, Leslie W., Genovese, Mark C., Berman, Alberto, Porto, Alejandro, Granel, Amelia, Asnal, Cecilia, Moreno, Jose Luis Cristian, Gulin, Juan Pablo, Hofman, Julio, Ulla, Maria Rosa, Sabelli, Mirtha, Mannucci, Pablo Alejandro, Melazzi, Ana Cláudia Cauceglia, Scotton, Antônio Scafuto, Funes, Elisete, Gimenez, Emerson Alves, Marcolino, Flora Maria D’Andrea, Neto, João Francisco Marques, Keiserman, Mauro Waldemar, Radominski, Sebastião Cézar, Lima, Sônia Maria Alvarenga Anti Loduca, Pavan, Thaís Rohde, Ivanova, Delina, Penev, Dimitar, Dimitrov, Emil, Kapandjieva, Nadezhda, Aleksieva, Tanya, Tsvetanova, Tanya, Popova, Valentina, Spasov, Yuliy, Arteaga Unigarro, Carlos Ernesto, Raad, Juan Jose Jaller, Lee, Chang Keun, Lee, Eun Young, Lee, Sang‐Heon, Kang, Seong Wook, Lee, Yun Jong, Torres, Isaura Rodriguez, Ceceña, Marco Maradiaga, Hernandez, Miguel Cortes, Zielinska, Agnieszka, Dudek, Anna, Rychlewska‐Hanczewska, Anna, Racewicz, Artur, Stasiuk, Barbara, Jeka, Slawomir, Lowenhoff, Tomasz, Rebrov, Andrey, Vinogradova, Irina, Ler, Irina, Savina, Ludmila, Stanislav, Marina, Sandin, Mikhail, Zyablova, Natalia, Mosesova, Nino, Polovnikova, Oksana, Nesmeyanova, Olga, Samigullina, Ruzana, Moiseev, Sergey, Raskina, Tatiana, Popova, Tatiana, Ristic, Gorica, Damjanov, Nemanja, Ostojic, Predrag, Yagensky, Andriy, Gnylorybov, Andriy, Rekalov, Dmytro, Gasanov, Iurii, Nadashkevych, Oleg, Yatsyshyn, Roman, Smiyan, Svitlana, Vizir, Vadym, Kachur, Victoria, Tseluyko, Vira, Povoroznyuk, Vladyslav, Koshlia, Volodymyr, Zhdan, Vyacheslav, Lymar, Yurii, Mostovoy, Yuriy, Hawkes, Angela, Mabaquiao, Arthur, Scoville, Craig, Wyatt, David, Weinstein, Debra, McIlwain, Harris, Poiley, Jeffrey, Dao, Kathryn, Turner, Mark, Genovese, Mark, Borofsky, Michael, Waller, Philip, Metyas, Samy, Shroff, Sharukh, Cohen, Stanley, Syed, Tauseef
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2020)
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