Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, Bennett G, Durik, Matej, Baker, Darren J, van Deursen, Jan M
Published in Nature medicine (01.12.2015)
Published in Nature medicine (01.12.2015)
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Journal Article
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, Bennett G, Baker, Darren J, Wijshake, Tobias, Conover, Cheryl A, Campisi, Judith, van Deursen, Jan M
Published in Science (American Association for the Advancement of Science) (28.10.2016)
Published in Science (American Association for the Advancement of Science) (28.10.2016)
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Journal Article
Senescence and apoptosis: dueling or complementary cell fates?
Childs, Bennett G, Baker, Darren J, Kirkland, James L, Campisi, Judith, van Deursen, Jan M
Published in EMBO reports (01.11.2014)
Published in EMBO reports (01.11.2014)
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Journal Article
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy
Kim, Seo Rin, Puranik, Amrutesh S, Jiang, Kai, Chen, Xiaojun, Zhu, Xiang-Yang, Taylor, Ian, Khodadadi-Jamayran, Alireza, Lerman, Amir, Hickson, LaTonya J, Childs, Bennett G, Textor, Stephen C, Tchkonia, Tamara, Niewold, Timothy B, Kirkland, James L, Lerman, Lilach O
Published in Journal of the American Society of Nephrology (01.08.2021)
Published in Journal of the American Society of Nephrology (01.08.2021)
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Journal Article
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1
Cohen, Camille, Le Goff, Océane, Soysouvanh, Frédéric, Vasseur, Florence, Tanou, Marine, Nguyen, Clément, Amrouche, Lucile, Le Guen, Julien, Saltel‐Fulero, Oriana, Meunier, Tanguy, Nguyen‐Khoa, Thao, Rabant, Marion, Nochy, Dominique, Legendre, Christophe, Friedlander, Gérard, Childs, Bennett G, Baker, Daren J, Knebelmann, Bertrand, Anglicheau, Dany, Milliat, Fabien, Terzi, Fabiola
Published in EMBO molecular medicine (08.11.2021)
Published in EMBO molecular medicine (08.11.2021)
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Journal Article
Senescent cells: a therapeutic target for cardiovascular disease
Childs, Bennett G, Li, Hu, van Deursen, Jan M
Published in The Journal of clinical investigation (01.04.2018)
Published in The Journal of clinical investigation (01.04.2018)
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Journal Article
Senescent cells: an emerging target for diseases of ageing
Childs, Bennett G., Gluscevic, Martina, Baker, Darren J., Laberge, Remi-Martin, Marquess, Dan, Dananberg, Jamie, van Deursen, Jan M.
Published in Nature reviews. Drug discovery (01.10.2017)
Published in Nature reviews. Drug discovery (01.10.2017)
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Journal Article
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
Baker, Darren J, Childs, Bennett G, Durik, Matej, Wijers, Melinde E, Sieben, Cynthia J, Zhong, Jian, Saltness, Rachel A, Jeganathan, Karthik B, Verzosa, Grace Casaclang, Pezeshki, Abdulmohammad, Khazaie, Khashayarsha, Miller, Jordan D, van Deursen, Jan M
Published in Nature (London) (11.02.2016)
Published in Nature (London) (11.02.2016)
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Journal Article
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels
Chini, Claudia C S, Peclat, Thais R, Warner, Gina M, Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C, Gomez, Lilian S, Hogan, Kelly A, Tarragó, Mariana G, Puranik, Amrutesh S, Agorrody, Guillermo, Thompson, Katie L, Dang, Kevin, Clarke, Starlynn, Childs, Bennett G, Kanamori, Karina S, Witte, Micaela A, Vidal, Paola, Kirkland, Anna L, De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R, Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L, Sedivy, John M, van Deursen, Jan M, Baker, Darren J, van Schooten, Wim, Rabinowitz, Joshua D, Baur, Joseph A, Chini, Eduardo N
Published in Nature metabolism (01.11.2020)
Published in Nature metabolism (01.11.2020)
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Journal Article
Loss of HD-PTP function results in lipodystrophy, defective cellular signaling and altered lipid homeostasis
Schultz, Destiny F, Davies, Brian A, Payne, Johanna A, Martin, Cole P, Minard, Annabel Y, Childs, Bennett G, Zhang, Cheng, Jeganathan, Karthik B, Sturmlechner, Ines, White, Thomas A, de Bruin, Alain, Harkema, Liesbeth, Chen, Huiqin, Davies, Michael A, Jachim, Sarah, LeBrasseur, Nathan K, Piper, Robert C, Li, Hu, Baker, Darren J, van Deursen, Jan, Billadeau, Daniel D, Katzmann, David J
Published in Journal of cell science (15.09.2024)
Published in Journal of cell science (15.09.2024)
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Journal Article
Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
Childs, Bennett G, Zhang, Cheng, Shuja, Fahad, Sturmlechner, Ines, Trewartha, Shawn, Fierro Velasco, Raul, Baker, Darren, Li, Hu, van Deursen, Jan M
Published in Nature aging (01.08.2021)
Published in Nature aging (01.08.2021)
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Journal Article
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, Darren J., Childs, Bennett G., Durik, Matej, Wijers, Melinde E., Sieben, Cynthia J., Zhong, Jian, A. Saltness, Rachel, Jeganathan, Karthik B., Verzosa, Grace Casaclang, Pezeshki, Abdulmohammad, Khazaie, Khashayarsha, Miller, Jordan D., van Deursen, Jan M.
Published in Nature (London) (03.02.2016)
Published in Nature (London) (03.02.2016)
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Journal Article
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, Darren J., Wijshake, Tobias, Tchkonia, Tamar, LeBrasseur, Nathan K., Childs, Bennett G., van de Sluis, Bart, Kirkland, James L., van Deursen, Jan M.
Published in Nature (London) (02.11.2011)
Published in Nature (London) (02.11.2011)
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Journal Article
The Role of Stem Cell Genomic Instability in Aging
Hommerding, Cynthia J., Childs, Bennett G., Baker, Darren J.
Published in Current stem cell reports (01.09.2015)
Published in Current stem cell reports (01.09.2015)
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Journal Article
METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
DAVID NATHANIEL, ELISSEEFF JENNIFER, LABERGE REMI MARTIN, KIM CHAEKYU, BAKER DARREN J, KIRKLAND JAMES L, JEON OKHEE, DAVALOS ALBERT, VASSEROT ALAIN PHILIPPE, TCHKONIA TAMAR, ZHU YI, CAMPISI JUDITH, VAN DEURSEN JAN M.A, DEMARIA MARCO, CHILDS BENNETT G
Year of Publication 10.10.2016
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Year of Publication 10.10.2016
Patent
Senescent intimai foam cells are deleterious at all stages of atherosclerosis
Childs, Bennett G., Baker, Darren J., Wijshake, Tobias, Conover, Cheryl A., Campisi, Judith, van Deursen, Jan M.
Published in Science (American Association for the Advancement of Science) (28.10.2016)
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Published in Science (American Association for the Advancement of Science) (28.10.2016)
Journal Article
Naturally occurring p16^sup Ink4a^-positive cells shorten healthy lifespan
Baker, Darren J, Childs, Bennett G, Durik, Matej, Wijers, Melinde E, Sieben, Cynthia J, Zhong, Jian, Saltness, Rachel A, Jeganathan, Karthik B, Verzosa, Grace Casaclang, Pezeshki, Abdulmohammad, Khazaie, Khashayarsha, Miller, Jordan D, van Deursen, Jan M
Published in Nature (London) (11.02.2016)
Published in Nature (London) (11.02.2016)
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Journal Article