Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
Kurimchak, Alison M., Shelton, Claude, Duncan, Kelly E., Johnson, Katherine J., Brown, Jennifer, O’Brien, Shane, Gabbasov, Rashid, Fink, Lauren S., Li, Yuesheng, Lounsbury, Nicole, Abou-Gharbia, Magid, Childers, Wayne E., Connolly, Denise C., Chernoff, Jonathan, Peterson, Jeffrey R., Duncan, James S.
Published in Cell reports (Cambridge) (02.08.2016)
Published in Cell reports (Cambridge) (02.08.2016)
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Journal Article
The Resurrection of Phenotypic Drug Discovery
Childers, Wayne E, Elokely, Khaled M, Abou-Gharbia, Magid
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol
Travaglianti, Shelby, Alotaibi, Ahmed, Wong, Woonyen, Abou-Gharbia, Magid, Childers, Wayne, Sari, Youssef
Published in Brain research bulletin (01.06.2024)
Published in Brain research bulletin (01.06.2024)
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Journal Article
Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Raynal, Noël J-M, Lee, Justin T, Wang, Youjun, Beaudry, Annie, Madireddi, Priyanka, Garriga, Judith, Malouf, Gabriel G, Dumont, Sarah, Dettman, Elisha J, Gharibyan, Vazganush, Ahmed, Saira, Chung, Woonbok, Childers, Wayne E, Abou-Gharbia, Magid, Henry, Ryan A, Andrews, Andrew J, Jelinek, Jaroslav, Cui, Ying, Baylin, Stephen B, Gill, Donald L, Issa, Jean-Pierre J
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice
León, Brandon Emanuel, Peyton, Lee, Essa, Hesham, Wieden, Tia, Marion, Nicole, Childers, Wayne E., Abou-Gharbia, Magid, Choi, Doo-Sup
Published in Neuropharmacology (01.07.2023)
Published in Neuropharmacology (01.07.2023)
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Journal Article
Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials”
Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
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Journal Article
Non-NAD-like PARP-1 inhibitors in prostate cancer treatment
Karpova, Yaroslava, Wu, Chao, Divan, Ali, McDonnell, Mark E., Hewlett, Elizabeth, Makhov, Peter, Gordon, John, Ye, Min, Reitz, Allen B., Childers, Wayne E., Skorski, Tomasz, Kolenko, Vladimir, Tulin, Alexei V.
Published in Biochemical pharmacology (01.09.2019)
Published in Biochemical pharmacology (01.09.2019)
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Journal Article
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz
Published in Blood (15.08.2013)
Published in Blood (15.08.2013)
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Journal Article
Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection
Sullivan, Katherine, Cramer-Morales, Kimberly, McElroy, Daniel L, Ostrov, David A, Haas, Kimberly, Childers, Wayne, Hromas, Robert, Skorski, Tomasz
Published in PloS one (19.01.2016)
Published in PloS one (19.01.2016)
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Journal Article
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
Fried, William, Tyagi, Mrityunjay, Minakhin, Leonid, Chandramouly, Gurushankar, Tredinnick, Taylor, Ramanjulu, Mercy, Auerbacher, William, Calbert, Marissa, Rusanov, Timur, Hoang, Trung, Borisonnik, Nikita, Betsch, Robert, Krais, John J., Wang, Yifan, Vekariya, Umeshkumar M., Gordon, John, Morton, George, Kent, Tatiana, Skorski, Tomasz, Johnson, Neil, Childers, Wayne, Chen, Xiaojiang S., Pomerantz, Richard T.
Published in Nature communications (05.04.2024)
Published in Nature communications (05.04.2024)
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Journal Article
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo
Butts, Arielle, Koselny, Kristy, Chabrier-Roselló, Yeissa, Semighini, Camile P, Brown, Jessica C S, Wang, Xuying, Annadurai, Sivakumar, DiDone, Louis, Tabroff, Julie, Childers, Jr, Wayne E, Abou-Gharbia, Magid, Wellington, Melanie, Cardenas, Maria E, Madhani, Hiten D, Heitman, Joseph, Krysan, Damian J
Published in mBio (11.02.2014)
Published in mBio (11.02.2014)
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Journal Article
Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry
Glassford, Ian, Teijaro, Christiana N, Daher, Samer S, Weil, Amy, Small, Meagan C, Redhu, Shiv K, Colussi, Dennis J, Jacobson, Marlene A, Childers, Wayne E, Buttaro, Bettina, Nicholson, Allen W, MacKerell, Alexander D, Cooperman, Barry S, Andrade, Rodrigo B
Published in Journal of the American Chemical Society (09.03.2016)
Published in Journal of the American Chemical Society (09.03.2016)
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Journal Article
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
Calbert, Marissa, Chandramouly, Gurushankar, Adams, Clare, Saez-Ayala, Magali, Kent, Tatiana, Tyagi, Mrityunjay, Ayyadevara, V.S.S. Abhinav, Wang, Yifan, Krais, John, Gordon, John, Atkins, Jessica, Toma, Monika, Betzi, Stéphane, Boghossian, Andrew, Rees, Matthew, Ronan, Melissa, Roth, Jennifer, Goldman, Aaron, Gorman, Nicole, Mitra, Ramkrishna, Childers, Wayne, Graña, Xavier, Skorski, Tomasz, Johnson, Neil, Hurtz, Christian, Morelli, Xavier, Eischen, Christine, Pomerantz, Richard
Published in Molecular cancer therapeutics (02.05.2024)
Published in Molecular cancer therapeutics (02.05.2024)
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Journal Article
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents
El-Awady, Raafat, Saleh, Ekram, Hamoudi, Rifat, Ramadan, Wafaa S., Mazitschek, Ralph, Nael, Manal A., Elokely, Khaled M., Abou-Gharbia, Magid, Childers, Wayne E., Srinivasulu, Vunnam, Aloum, Lujain, Menon, Varsha, Al-Tel, Taleb H.
Published in Bioorganic & medicinal chemistry (15.07.2021)
Published in Bioorganic & medicinal chemistry (15.07.2021)
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Journal Article
Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms
AlAsmari, Abdullah F., Alshehri, Mohammed M., Ali, Nemat, AlAsmari, Fawaz, Sari, Youssef, Childers, Wayne E., Abou-Gharbia, Magid, Alharbi, Metab, Elnagar, Doaa M., AL-Qahtani, Wejdan S.
Published in Saudi pharmaceutical journal (01.09.2024)
Published in Saudi pharmaceutical journal (01.09.2024)
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Journal Article