The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
Gaich, Gregory, Chien, Jenny Y., Fu, Haoda, Glass, Leonard C., Deeg, Mark A., Holland, William L., Kharitonenkov, Alexei, Bumol, Thomas, Schilske, Holger K., Moller, David E.
Published in Cell metabolism (03.09.2013)
Published in Cell metabolism (03.09.2013)
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Journal Article
A Quantitative Modeling and Simulation Framework to Support Candidate and Dose Selection of Anti‐SARS‐CoV‐2 Monoclonal Antibodies to Advance Bamlanivimab Into a First‐in‐Human Clinical Trial
Chigutsa, Emmanuel, Jordie, Eric, Riggs, Matthew, Nirula, Ajay, Elmokadem, Ahmed, Knab, Tim, Chien, Jenny Y.
Published in Clinical pharmacology and therapeutics (01.03.2022)
Published in Clinical pharmacology and therapeutics (01.03.2022)
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Journal Article
Clinical Pharmacokinetics of Dulaglutide in Patients with Type 2 Diabetes: Analyses of Data from Clinical Trials
Geiser, Jeanne S., Heathman, Michael A., Cui, Xuewei, Martin, Jennifer, Loghin, Corina, Chien, Jenny Y., de la Peña, Amparo
Published in Clinical pharmacokinetics (01.05.2016)
Published in Clinical pharmacokinetics (01.05.2016)
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Journal Article
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance
Ring, Barbara J., Chien, Jenny Y., Adkison, Kimberly K., Jones, Hannah M., Rowland, Malcolm, Jones, Rhys Do, Yates, James W.T., Ku, M. Sherry, Gibson, Christopher R., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach
Poulin, Patrick, Jones, Rhys D.O., Jones, Hannah M., Gibson, Christopher R., Rowland, Malcolm, Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Yates, James W.T.
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
Development and Qualification of a Drug-Disease Modeling Platform to Characterize Clinically Relevant Endpoints in Type 2 Diabetes Trials
Gaitonde, Puneet, Hurtado, Felipe K, Garhyan, Parag, Chien, Jenny Y, Schmidt, Stephan
Published in Clinical pharmacology and therapeutics (01.10.2018)
Published in Clinical pharmacology and therapeutics (01.10.2018)
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Journal Article
Development and Verification of a Body Weight-Directed Disease Trial Model for Glucose Homeostasis
Farhan, Nashid, Gebert, Ines, Xing, Yifan, Wieser, Katharina, Lingineni, Karthik, Ma, Xiaosu, Chien, Jenny Y, Garhyan, Parag, Schmidt, Stephan
Published in Journal of clinical pharmacology (01.02.2021)
Published in Journal of clinical pharmacology (01.02.2021)
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Journal Article
Optimization of trial duration to predict long‐term HbA1c change with therapy: A pharmacometrics simulation‐based evaluation
Kunina, Hanna, Al‐Mashat, Alex, Chien, Jenny Y., Garhyan, Parag, Kjellsson, Maria C.
Published in CPT: pharmacometrics and systems pharmacology (01.11.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.11.2022)
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Journal Article
A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development
Gaitonde, Puneet, Garhyan, Parag, Link, Catharina, Chien, Jenny Y., Trame, Mirjam N., Schmidt, Stephan
Published in Clinical pharmacokinetics (01.07.2016)
Published in Clinical pharmacokinetics (01.07.2016)
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Journal Article
PK/PD modeling links accelerated resolution of COVID‐19‐related clinical symptoms to SARS‐CoV‐2 viral load reduction in patients following treatment with Bamlanivimab alone or Bamlanivimab and Etesevimab together
Ernest, C. Steven, Chien, Jenny Y., Patel, Dipak R., Chigutsa, Emmanuel
Published in CPT: pharmacometrics and systems pharmacology (01.06.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2022)
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Journal Article
Simulation-Based Evaluation of Dose-Titration Algorithms for Rapid-Acting Insulin in Subjects with Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Antihyperglycemic Medications
Ma, Xiaosu, Chien, Jenny Y, Johnson, Jennal, Malone, James, Sinha, Vikram
Published in Diabetes technology & therapeutics (01.08.2017)
Published in Diabetes technology & therapeutics (01.08.2017)
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Journal Article
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution
Jones, Rhys Do, Jones, Hannah M., Rowland, Malcolm, Gibson, Christopher R., Yates, James W.T., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
Optimization of drug-drug interaction study design: comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole
Han, Bing, Mao, Jialin, Chien, Jenny Y, Hall, Stephen D
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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Journal Article
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach
Vuppugalla, Ragini, Marathe, Punit, He, Handan, Jones, Rhys D.O., Yates, James W.T., Jones, Hannah M., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets
Poulin, Patrick, Jones, Hannah M., Jones, Rhys Do, Yates, James W.T., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Sherry Ku, M.
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial
Upadhyaya, Himanshu P., Chien, Jenny Y., Long, Amanda J., Bohm, Martin S., Kallewaard, Nicole L., Macpherson, Lisa F., Patel, Dipak R., Hufford, Matthew M., Krull, Constance J., Ang, Jocelyn Y., Chen, Peter, Muller, William J., Potts, Jeffrey A., Quinn, Timothy, Williams, Mark
Published in Infectious diseases and therapy (01.07.2023)
Published in Infectious diseases and therapy (01.07.2023)
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Journal Article
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease
Emery, Maurice G., Fisher, Jeannine M., Chien, Jenny Y., Kharasch, Evan D., Dellinger, E.Patchen, Kowdley, Kris V., Thummel, Kenneth E.
Published in Hepatology (Baltimore, Md.) (01.08.2003)
Published in Hepatology (Baltimore, Md.) (01.08.2003)
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