Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei
Published in Nature (29.11.2007)
Published in Nature (29.11.2007)
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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators
Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Fatty Acid Cysteamine Conjugates as Novel and Potent Autophagy Activators That Enhance the Correction of Misfolded F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Vu, Chi B, Bridges, Robert J, Pena-Rasgado, Cecilia, Lacerda, Antonio E, Bordwell, Curtis, Sewell, Abby, Nichols, Andrew J, Chandran, Sachin, Lonkar, Pallavi, Picarella, Dominic, Ting, Amal, Wensley, Allison, Yeager, Maisy, Liu, Feng
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid
Vu, Chi B, Bemis, Jean E, Benson, Ericka, Bista, Pradeep, Carney, David, Fahrner, Richard, Lee, Diana, Liu, Feng, Lonkar, Pallavi, Milne, Jill C, Nichols, Andrew J, Picarella, Dominic, Shoelson, Adam, Smith, Jesse, Ting, Amal, Wensley, Allison, Yeager, Maisy, Zimmer, Michael, Jirousek, Michael R
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida
McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
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CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E3‐Leiden mice
Zimmer, Michael, Bista, Pradeep, Benson, Ericka L., Lee, Diana Y., Liu, Feng, Picarella, Dominic, Vega, Rick B., Vu, Chi B., Yeager, Maisy, Ding, Min, Liang, Guosheng, Horton, Jay D., Kleemann, Robert, Kooistra, Teake, Morrison, Martine C., Wielinga, Peter Y., Milne, Jill C., Jirousek, Michael R., Nichols, Andrew J.
Published in Hepatology communications (01.06.2017)
Published in Hepatology communications (01.06.2017)
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Journal Article
Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors
Vu, Chi B., Milne, Jill C., Carney, David P., Song, Jeffrey, Choy, Wendy, Lambert, Philip D., Gagne, David J., Hirsch, Michael, Cote, Angela, Davis, Meghan, Lainez, Elden, Meade, Nekeya, Normington, Karl, Jirousek, Michael R., Perni, Robert B.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists
Vu, Chi B, Kiesman, William F, Conlon, Patrick R, Lin, Ko-Chung, Tam, Melissa, Petter, Russell C, Smits, Glenn, Lutterodt, Frank, Jin, Xiaowei, Chen, Liqing, Zhang, Jianbo
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Journal Article
Novel Diamino Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists
Vu, Chi B, Pan, Deborah, Peng, Bo, Kumaravel, Gnanasambandam, Smits, Glenn, Jin, Xiaowei, Phadke, Deepali, Engber, Thomas, Huang, Carol, Reilly, Jennifer, Tam, Stacy, Grant, Donna, Hetu, Gregg, Petter, Russell C
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists
VU, Chi B, SHIELDS, Pamela, BO PENG, KUMARAVEL, Gnanasambandam, XIAOWEI JIN, PHADKE, Deepali, WANG, Joy, ENGBER, Thomas, AYYUB, Eman, PETTER, Russell C
Published in Bioorganic & medicinal chemistry letters (01.10.2004)
Published in Bioorganic & medicinal chemistry letters (01.10.2004)
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Journal Article
Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists
VU, Chi B., PENG, Bo, KUMARAVEL, Gnanasambandam, SMITS, Glenn, JIN, Xiaowei, PHADKE, Deepali, ENGBER, Thomas, HUANG, Carol, REILLY, Jennifer, TAM, Stacy, GRANT, Donna, HETU, Gregg, CHEN, Liqing, ZHANG, Jianbo, PETTER, Russell C.
Published in Journal of medicinal chemistry (12.08.2004)
Published in Journal of medicinal chemistry (12.08.2004)
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Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents
Vu, Chi B., Luke, George P., Kawahata, Noriyuki, Shakespeare, William C., Wang, Yihan, Sundaramoorthi, Raji, Metcalf, Chester A., Keenan, Terence P., Pradeepan, Selvi, Corpuz, Evelyn, Merry, Taylor, Bohacek, Regine S., Dalgarno, David C., Narula, Surinder S., van Schravendijk, Marie Rose, Ram, Mary K., Adams, Susan, Liou, Shuenn, Keats, Jeffrey A., Violette, Shelia M., Guan, Wei, Weigele, Manfred, Sawyer, Tomi K.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles
VU, Chi B, PAN, Deborah, TAM, Stacy, PETTER, Russell C, BO PENG, LI SHA, KUMARAVEL, Gnanasambandam, XIAOWEI JIN, PHADKE, Deepali, ENGBER, Thomas, HUANG, Carol, REILLY, Jennifer
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70
Vu, Chi B, Corpuz, Evelyn G, Merry, Taylor J, Pradeepan, Selvaluxmi G, Bartlett, Catherine, Bohacek, Regine S, Botfield, Martyn C, Eyermann, Charles J, Lynch, Berkley A, MacNeil, Ian A, Ram, Mary K, van Schravendijk, Marie Rose, Violette, Shelia, Sawyer, Tomi K
Published in Journal of medicinal chemistry (07.10.1999)
Published in Journal of medicinal chemistry (07.10.1999)
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Journal Article
Preservation of Mitochondrial Bioenergetics with CAT-4001 after Peroxide Injury
Thomson, Alexander H., Allen, Mitchell E., Perry, Justin B., Nichols, Andrew J., Reilly, John F., Bista, Pradeep, Lee, Diana, Vu, Chi B., Brown, David A.
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
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Selective Inhibition of Src SH2 by a Novel Thiol-Targeting Tricarbonyl-Modified Inhibitor and Mechanistic Analysis by 1H/ 13C NMR Spectroscopy
Sundaramoorthi, Raji, Siedem, Chris, Vu, Chi B, Dalgarno, David C, Laird, Ellen C, Botfield, Martyn C, Combs, Amanda B, Adams, Susan E, Yuan, Ruth W, Weigele, Manfred, Narula, Surinder S
Published in Bioorganic & medicinal chemistry letters (01.07.2001)
Published in Bioorganic & medicinal chemistry letters (01.07.2001)
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