Search Results - "CHERUVALLATH, ZACHARIA, S" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors

Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors

by Farrell, Pamela J, Zopf, Christopher J, Huang, Huey-Jing, Balakrishna, Deepika, Holub, Corine, Bilakovics, James, Fanjul, Andrea, Matuszkiewicz, Jennifer, Plonowski, Artur, Rolzin, Paul, Banerjee, Urmi, Ermolieff, Jacques, Cheruvallath, Zacharia S, McBride, Christopher, Bartkowski, Darian, Mazur, Crystal, Pachori, Alok, Larson, Christopher J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)

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Journal Article

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy

by Murphy, Sean T., Atienza, Joy, Brown, Jason W., Cheruvallath, Zacharia S., Cukierski, Matthew J., Fabrey, Robyn, Keung, Walter, Kwok, Lily, O'Connell, Shawn, Tang, Mingnam, Vanderpool, Darin L., Vincent, Patrick W., Zhang, Lilly, Marx, Matthew A.
Published in ACS medicinal chemistry letters (09.11.2023)

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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

by Cheruvallath, Zacharia S., Gwaltney, Stephen L., Sabat, Mark, Tang, Mingnam, Wang, Haixia, Jennings, Andy, Hosfield, David, Lee, Bumsup, Wu, Yiqin, Halkowycz, Petro, Grimshaw, Charles E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)

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Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

by Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve
Published in ACS medicinal chemistry letters (09.03.2017)

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Design, synthesis and SAR of novel glucokinase activators

Design, synthesis and SAR of novel glucokinase activators

by Cheruvallath, Zacharia S., Gwaltney, Stephen L., Sabat, Mark, Tang, Mingnam, Feng, Jun, Wang, Haixia, Miura, Joanne, Guntupalli, Prasuna, Jennings, Andy, Hosfield, David, Lee, Bumsup, Wu, Yiqin
Published in Bioorganic & medicinal chemistry letters (01.04.2013)

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A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

by Cheruvallath, Zacharia S, Cole, Douglas L, Ravikumar, Vasulinga T
Published in Bioorganic & medicinal chemistry letters (01.01.2003)

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Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”

Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”

by Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, McBride, Christopher, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve
Published in ACS medicinal chemistry letters (14.12.2017)

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(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

by Cheruvallath, Zacharia S, Eleuteri, Alessandra, Turney, Brett, Ravikumar, Vasulinga T
Published in Organic process research & development (01.03.2006)

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Journal Article

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

by Cheruvallath, Zacharia S, Carty, Recaldo L, Moore, Max N, Capaldi, Daniel C, Krotz, Achim H, Wheeler, Patrick D, Turney, Brett J, Craig, Stephen R, Gaus, Hans J, Scozzari, Anthony N, Cole, Douglas L, Ravikumar, Vasulinga T
Published in Organic process research & development (01.05.2000)

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Synthesis of biologically active taxol analogs with modified phenylisoserine side chains

Synthesis of biologically active taxol analogs with modified phenylisoserine side chains

by Georg, Gunda I, Cheruvallath, Zacharia S, Himes, Richard H, Mejillano, Magdalena R, Burke, Charles T
Published in Journal of medicinal chemistry (01.10.1992)

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Journal Article

Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

by Cheruvallath, Zacharia S, Carty, Recaldo L, Andrade, Mark, Moore, Max N, Song, Quinlai, Rentel, Claus, Cole, Douglas L, Ravikumar, Vasulinga T
Published in Organic process research & development (01.11.2003)

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Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

by Cheruvallath, Zacharia S., Kumar, R. Krishna, Rentel, Claus, Cole, Douglas L., Ravikumar, Vasulinga T.
Published in Nucleosides, nucleotides & nucleic acids (01.01.2003)

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Journal Article

An efficient semisynthesis of taxol from (3 R,4 S)- N-Benzoyl-3-[( t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III

An efficient semisynthesis of taxol from (3 R,4 S)- N-Benzoyl-3-[( t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III

by Georg, Gunda I., Cheruvallath, Zacharia S., Harriman, Geraldine C.B., Hepperle, Michael, Park, Haeil
Published in Bioorganic & medicinal chemistry letters (01.11.1993)

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Journal Article

Samarium Diiodide-Mediated Deoxygenation of Taxol: A One-Step Synthesis of 10-Deacetoxytaxol

Samarium Diiodide-Mediated Deoxygenation of Taxol: A One-Step Synthesis of 10-Deacetoxytaxol

by Georg, Gunda I, Cheruvallath, Zacharia S
Published in Journal of organic chemistry (01.07.1994)

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Journal Article

6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

by MCBRIDE, Christopher, CHERUVALLATH, Zacharia S, STAFFORD, Jeffrey A, VEAL, James M
Year of Publication 14.09.2023

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Patent

6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

by MCBRIDE, Christopher, CHERUVALLATH, Zacharia S, STAFFORD, Jeffrey A, VEAL, James M
Year of Publication 06.07.2023

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Patent

Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

by Georg, Gunda I., Boge, Thomas C., Cheruvallath, Zacharia S., Harriman, Geraldine C.B., Hepperle, Michael, Park, Haeil, Himes, Richard H.
Published in Bioorganic & medicinal chemistry letters (20.01.1994)

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Journal Article

Métodos para sintetizar oligonucleótidos sulfurados

Métodos para sintetizar oligonucleótidos sulfurados

by COLE, DOUGLAS L, CHERUVALLATH, ZACHARIA S, RAVIKUMAR, VASULINGA T
Year of Publication 23.06.2014

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Patent

IMPROVED SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES

IMPROVED SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES

by COLE, DOUGLAS, L, RAVIKUMAR, VASULINGA, T, CHERUVALLATH, ZACHARIA, S
Year of Publication 21.05.2014

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Patent

4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

by Ravikumar, Vasulinga T., Cheruvallath, Zacharia S., Cole, Douglas L.
Published in Tetrahedron letters (09.09.1996)

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