1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b
Semple, Graeme, Skinner, Philip J, Cherrier, Martin C, Webb, Peter J, Sage, Carleton R, Tamura, Susan Y, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a
Skinner, Philip J., Cherrier, Martin C., Webb, Peter J., Shin, Young-Jun, Gharbaoui, Tawfik, Lindstrom, Andrew, Hong, Vu, Tamura, Susan Y., Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O, Kasem, Michelle, Johnson, Benjamin R, Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C, Webb, Peter J, Semple, Graeme, Sage, Carleton R, Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K, Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L, Tata, James R, Connolly, Daniel T, Waters, M. Gerard, Richman, Jeremy G
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Journal Article
3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice
Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Journal Article
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)
Boatman, P. Douglas, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip J., Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Taggart, Andrew K., Carballo-Jane, Ester, Richman, Jeremy G.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b
Skinner, Philip J., Cherrier, Martin C., Webb, Peter J., Sage, Carleton R., Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Tamura, Susan Y., Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Agonist lead identification for the high affinity niacin receptor GPR109a
Gharbaoui, Tawfik, Skinner, Philip J., Shin, Young-Jun, Averbuj, Claudia, Jung, Jae-Kyu, Johnson, Benjamin R., Duong, Tracy, Decaire, Marc, Uy, Jane, Cherrier, Martin C., Webb, Peter J., Tamura, Susan Y., Zou, Ning, Rodriguez, Nathalie, Boatman, P. Douglas, Sage, Carleton R., Lindstrom, Andrew, Xu, Jerry, Schrader, Thomas O., Smith, Brian M., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Colletti, Steven L., Tata, James R., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K., Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L., Tata, James R., Connolly, Daniel T., Waters, M. Gerard, Richman, Jeremy G.
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
ULLMAN, Brett, CHOI, Jin Sun Karoline, TEEGARDEN, Bradley, SMITH, Brian M, DOSA, Peter I, XIONG, Yifeng, STRAH-PLEYNET, Sonja, CHERRIER, Martin C
Year of Publication 13.02.2020
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Year of Publication 13.02.2020
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Xiong, Yifeng, Strah-Pleynet, Sonja, Dosa, Peter I, Teegarden, Bradley, Smith, Brian M, Ullman, Brett, Cherrier, Martin C, Choi, Jin Sun Karoline
Year of Publication 16.07.2019
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Year of Publication 16.07.2019
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
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Year of Publication 13.03.2018
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Year of Publication 13.03.2018
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 09.11.2017
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Year of Publication 09.11.2017
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 15.08.2017
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Year of Publication 15.08.2017
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Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Teegarden Bradley, Strah-Pleynet Sonja, Choi Jin Sun Karoline, Smith Brian M, Ullman Brett, Dosa Peter I, Cherrier Martin C, Xiong Yifeng
Year of Publication 06.09.2016
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Year of Publication 06.09.2016
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
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Year of Publication 17.03.2016
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Year of Publication 17.03.2016
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Pyrazole Derivatives As Modulators Of The 5-HT2A Serotoninreceptor Useful For The Treatment Of Disorders Related Thereto
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Year of Publication 15.03.2016
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Year of Publication 15.03.2016
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Pyrazole derivatives as modulators of 5-ht2a serotonin receptor useful for treatment of disorders related thereto
XIONG YIFENG, CHERRIER MARTIN C, CHOI JIN SUN KAROLINE, DOSA PETER I, SMITH BRIAN M, ULLMAN BRET, TEEGARDEN BRADLEY, STRAH-PLEYNET SONJA
Year of Publication 15.07.2015
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Year of Publication 15.07.2015
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
ULLMAN, BRET, STRAH-PLEYNET, SONJA, XIONG, YIFENG, DOSA, PETER, I, CHOI, JIN SUN, KAROLINE, CHERRIER, MARTIN, C, SMITH, BRIAN, M, TEEGARDEN, BRADLEY
Year of Publication 04.06.2014
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Year of Publication 04.06.2014
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PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
XIONG YIFENG, ULLMAN BRETT, CHERRIER MARTIN C, CHOI JIN SUN KAROLINE, DOSA PETER I, SMITH BRIAN M, TEEGARDEN BRADLEY, STRAH-PLEYNET SONJA
Year of Publication 22.08.2013
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Year of Publication 22.08.2013
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