Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer
Cai, Xiong, Zhai, Hai-Xiao, Wang, Jing, Forrester, Jeffrey, Qu, Hui, Yin, Ling, Lai, Cheng-Jung, Bao, Rudi, Qian, Changgeng
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling
CHANGGENG QIAN, LAI, Cheng-Jung, ZIFCAK, Brian, ANNA WAI SEE MA, DELLAROCCA, Steven, BOREK, Mylissa, ZHAI, Hai-Xiao, XIONG CAI, VOI, Maurizio, RUDI BAO, WANG, Da-Gong, JING WANG, XU, Guang-Xin, ATOYAN, Ruzanna, HUI QU, LING YIN, SAMSON, Maria
Published in Clinical cancer research (01.08.2012)
Published in Clinical cancer research (01.08.2012)
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CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity
LAI, Cheng-Jung, RUDI BAO, ZIFCAK, Brian, XU, Guang-Xin, DELLAROCCA, Steven, ZHAI, Hai-Xiao, XIONG CAI, MUNGER, William E, KEEGAN, Mitchell, PEPICELLI, Carmen V, CHANGGENG QIAN, XU TAO, JING WANG, ATOYAN, Ruzanna, HUI QU, WANG, Da-Gong, LING YIN, SAMSON, Maria, FORRESTER, Jeffrey
Published in Cancer research (Chicago, Ill.) (01.05.2010)
Published in Cancer research (Chicago, Ill.) (01.05.2010)
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Journal Article
CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
Bao, Rudi, Lai, Cheng-Jung, Qu, Hui, Wang, Dagong, Yin, Ling, Zifcak, Brian, Atoyan, Ruzanna, Wang, Jing, Samson, Maria, Forrester, Jeffrey, DellaRocca, Steven, Xu, Guang-Xin, Tao, Xu, Zhai, Hai-Xiao, Cai, Xiong, Qian, Changgeng
Published in Clinical cancer research (15.06.2009)
Published in Clinical cancer research (15.06.2009)
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Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer
Bao, Rudi, Lai, Cheng-Jung, Wang, Da-Gong, Qu, Hui, Yin, Ling, Zifcak, Brian, Tao, Xu, Wang, Jing, Atoyan, Ruzanna, Samson, Maria, Forrester, Jeffrey, Xu, Guang-Xin, DellaRocca, Steven, Borek, Mylissa, Zhai, Hai-Xiao, Cai, Xiong, Qian, Changgeng
Published in Molecular cancer therapeutics (01.12.2009)
Published in Molecular cancer therapeutics (01.12.2009)
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Journal Article
A frizzled homolog functions in a vertebrate Wnt signaling pathway
Yang-Snyder, J, Miller, J R, Brown, J D, Lai, C J, Moon, R T
Published in Current biology (01.10.1996)
Published in Current biology (01.10.1996)
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Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion
Wang, Jing, Pursell, Natalie W, Samson, Maria Elena S, Atoyan, Ruzanna, Ma, Anna W, Selmi, Abdelkader, Xu, Wanlu, Cai, Xiong, Voi, Maurizio, Savagner, Pierre, Lai, Cheng-Jung
Published in Molecular cancer therapeutics (01.06.2013)
Published in Molecular cancer therapeutics (01.06.2013)
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Journal Article
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
Ekker, S C, McGrew, L L, Lai, C J, Lee, J J, von Kessler, D P, Moon, R T, Beachy, P A
Published in Development (Cambridge) (01.08.1995)
Published in Development (Cambridge) (01.08.1995)
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Expression of Wnt10a in the Central Nervous System of Developing Zebrafish
Kelly, Gregory M., Lai, Cheng-Jung, Moon, Randall T.
Published in Developmental biology (01.07.1993)
Published in Developmental biology (01.07.1993)
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A First-In-Man Phase 1 Study Of CUDC-907, a First-In-Class Chemically-Designed Dual Inhibitor Of PI3K and HDAC In Patients With Refractory Or Relapsed Lymphoma and Multiple Myeloma
Younes, Anas, Flinn, Ian W., Oki, Yasuhiro, Copland, Amanda, Fattaey, Ali, Lai, Cheng-Jung, Laliberte, Robert, Voi, Maurizio, Berdeja, Jesus G
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Abstract B268: A Phase I Study of CUDC-101, a multitarget inhibitor of HDACs, EGFR, and HER2, in combination with chemoradiation in patients with intermediate/high risk locally advanced squamous cell carcinoma of the head and neck
Jimeno, Antonio, Galloway, Thomas, Wirth, Lori, Gilbert, Jill, Saba, Nabil, Bauman, Julie, Colevas, Dimitrios, Mehra, Ranee, Raben, David, Lai, Cheng-Jung, Laliberte, Robert, Voi, Maurizio, Burtness, Barbara
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
CUDC-907, a Dual HDAC and PI3K Inhibitor, Potentially Targets Cancer Cells and The Microenvironment In Hematological Malignancies
Wang, Jing, Pursell, Natalie, Ma, Anna, Atoyan, Ruzanna, Samson, Maria, Borek, Mylissa, DellaRocca, Steven, Yin, Ling, Wang, Da-gong, Zifcak, Brian, Xu, Guang-xin, Voi, Maurizio, Lai, Cheng-Jung
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Abstract 3744: Antitumor activity of CUDC-907, a dual PI3K and HDAC inhibitor, in hematological cancer models
Rudi, Bao, Wang, Dagong, Qu, Hui, Yin, Ling, Zifcak, Brian, DellaRocca, Steven, Xu, Guang-Xin, Borek, Mylissa, Samson, Maria, Atoyan, Ruzanna, Poli, Anne, Wang, Jing, Zhai, Hai-Xaio, Lai, Cheng-Jung, Pepicelli, Carmen, Cai, Xiong, Qian, Changgeng
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract C70: Antitumor activity of CUDC-907, a single small molecule inhibitor that targets both PI3K and HDAC, in hematologic cancer models
Bao, Rudi, Wang, Dagong, Qu, Hui, Wang, Jing, Atoyan, Ruzanna, Xu, Guang-Xin, Yin, Ling, Zifcak, Brian, Borek, Mylissa, Samson, Maria, Ma, Anna, DellaRocca, Steven, Zhai, Hai-Xiao, Lai, Cheng-Jung, Pepicelli, Carmen, Cai, Xiong, Qian, Changgeng
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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