Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer
Chi, Kim N, Agarwal, Neeraj, Bjartell, Anders, Chung, Byung Ha, Pereira de Santana Gomes, Andrea J, Given, Robert, Juárez Soto, Álvaro, Merseburger, Axel S, Özgüroğlu, Mustafa, Uemura, Hirotsugu, Ye, Dingwei, Deprince, Kris, Naini, Vahid, Li, Jinhui, Cheng, Shinta, Yu, Margaret K, Zhang, Ke, Larsen, Julie S, McCarthy, Sharon, Chowdhury, Simon
Published in The New England journal of medicine (04.07.2019)
Published in The New England journal of medicine (04.07.2019)
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Docetaxel and dasatinib or placebo in men with metastatic castration-resistant prostate cancer (READY): a randomised, double-blind phase 3 trial
Araujo, John C, Dr, Trudel, Géralyn C, PhD, Saad, Fred, Prof, Armstrong, Andrew J, MD, Yu, Evan Y, MD, Bellmunt, Joaquim, MD, Wilding, George, Prof, McCaffrey, John, Prof, Serrano, Sergio V, MD, Matveev, Vsevolod B, Prof, Efstathiou, Eleni, MD, Oudard, Stephane, Prof, Morris, Michael J, MD, Sizer, Bruce, MBChB, Goebell, Peter J, MD, Heidenreich, Axel, Prof, de Bono, Johann S, Prof, Begbie, Stephen, MBBS, Hong, Jun H, MD, Richardet, Eduardo, MD, Gallardo, Enrique, MD, Paliwal, Prashni, PhD, Durham, Susan, BA, Cheng, Shinta, MD, Logothetis, Christopher J, Prof
Published in The lancet oncology (01.12.2013)
Published in The lancet oncology (01.12.2013)
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Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer
YU, Evan Y, WILDING, George, TRUDEL, Géralyn C, PALIWAL, Prashni, STERNBERG, Cora N, POSADAS, Edwin, GROSS, Mitchell, CULINE, Stephane, MASSARD, Christophe, MORRIS, Michael J, HUDES, Gary, CALABRO, Fabio, SHINTA CHENG
Published in Clinical cancer research (01.12.2009)
Published in Clinical cancer research (01.12.2009)
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P913: LOW‐DOSE BELANTAMAB MAFODOTIN (BELAMAF) IN COMBINATION WITH NIROGACESTAT VS BELAMAF MONOTHERAPY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): PHASE 1/2 DREAMM‐5 PLATFORM SUB‐STUDY 3
Callander, Natalie, Richardson, Paul, Hus, Marek, Ribrag, Vincent, Martinez‐Lopez, Joaquín, Kim, Kihyun, Hoon Lee, Jae, Dimopoulos, Meletios A., Schjesvold, Fredrik, Facon, Thierry, Jo, Jae‐Cheol, Min, Chang‐Ki, Mielnik, Michał, Cheng, Shinta, Smith, Mary, Breitbach, Caroline J., Brawley, Chris, Sembhi, Harjeet, Lamacchia, John, Grosicki, Sebastian
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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The Androgen Receptor Recruits Nuclear Receptor CoRepressor (N-CoR) in the Presence of Mifepristone via Its N and C Termini Revealing a Novel Molecular Mechanism for Androgen Receptor Antagonists
Hodgson, Myles C., Astapova, Inna, Cheng, Shinta, Lee, Larissa J., Verhoeven, Manon C., Choi, Eunis, Balk, Steven P., Hollenberg, Anthony N.
Published in The Journal of biological chemistry (25.02.2005)
Published in The Journal of biological chemistry (25.02.2005)
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A Phase I Trial of the Novel Farnesyl Protein Transferase Inhibitor, BMS-214662, in Combination with Paclitaxel and Carboplatin in Patients with Advanced Cancer
DY, Grace K, BRUZEK, Laura M, CHENG, Shinta, MARTELL, Robert E, KAUFMANN, Scott H, ADJEI, Alex A, CROGHAN, Gary A, MANDREKAR, Sumithra, ERLICHMAN, Charles, PEETHAMBARAM, Prema, PITOT, Henry C, HANSON, Lorelei J, REID, Joel M, FURTH, Alfred
Published in Clinical cancer research (01.03.2005)
Published in Clinical cancer research (01.03.2005)
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Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography in Men with Nonmetastatic Castration-Resistant Prostate Cancer
Fendler, Wolfgang P, Weber, Manuel, Iravani, Amir, Hofman, Michael S, Calais, Jérémie, Czernin, Johannes, Ilhan, Harun, Saad, Fred, Small, Eric J, Smith, Matthew R, Perez, Paola M, Hope, Thomas A, Rauscher, Isabel, Londhe, Anil, Lopez-Gitlitz, Angela, Cheng, Shinta, Maurer, Tobias, Herrmann, Ken, Eiber, Matthias, Hadaschik, Boris
Published in Clinical cancer research (15.12.2019)
Published in Clinical cancer research (15.12.2019)
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Trial in progress: A phase two trial of nirogacestat, a gamma-secretase inhibitor, in patients with recurrent ovarian granulosa cell tumors (NCT05348356) (1284)
Konstantinopoulos, Panagiotis, Lewis, Jocelyn, Shearer, Todd, Kaiser, Heather, Breitbach, Caroline, Cheng, Shinta
Published in Gynecologic oncology (01.09.2023)
Published in Gynecologic oncology (01.09.2023)
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Population pharmacokinetic-pharmacodynamic model of nirogacestat effects on B-cell maturation antigen in healthy subjects
Shearer, Todd, Williams, Rex L., Johnson, Mark, Cendrowicz, Ewa, Leonowens, Cathrine, Smith, Margaret, Baughman, Todd, Breitbach, Caroline J., Smith, L. Mary, Cheng, Shinta
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Pharmacodynamic Effects of Nirogacestat, a Gamma Secretase Inhibitor, on B-Cell Maturation Antigen in Healthy Participants
Shearer, Todd, Williams, Rex L., Johnson, Mark, Cendrowicz, Ewa, Leonowens, Cathrine, Smith, Margaret, Baughman, Todd, Breitbach, Caroline J., Smith, L. Mary, Burgess, Michael, Cheng, Shinta
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Association of detectable levels of circulating tumor DNA (ctDNA) with disease burden in prostate cancer (PC)
Attard, Gerhardt, Gormley, Michael, Urtishak, Karen, Simon, Jason S., Ricci, Deborah S., Parekh, Trilok V., Cheng, Shinta, Chi, Kim N., Smith, Matthew Raymond
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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A phase III randomized, placebo-controlled, double-blind study of niraparib plus abiraterone acetate and prednisone versus abiraterone acetate and prednisone in patients with metastatic prostate cancer (MAGNITUDE)
Chi, Kim N., Rathkopf, Dana E., Attard, Gerhardt, Smith, Matthew Raymond, Efstathiou, Eleni, Olmos, David, Small, Eric Jay, Lee, Ji Youl, Ricci, Deborah S., Simon, Jason S., Zhao, Xin, Kothari, Nishi, Cheng, Shinta, Sandhu, Shahneen Kaur
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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A phase III randomized, placebo-controlled, double-blind study of niraparib plus abiraterone acetate and prednisone versus abiraterone acetate and prednisone in patients with metastatic prostate cancer (NCT03748641)
Chi, Kim N., Rathkopf, Dana E., Attard, Gerhardt, Smith, Matthew Raymond, Efstathiou, Eleni, Olmos, David, Small, Eric Jay, Lee, Ji Youl, Sieber, Paul R., Dunshee, Curtis, Ricci, Deborah S., Simon, Jason S., Zhao, Xin, Kothari, Nishi, Cheng, Shinta, Sandhu, Shahneen Kaur
Published in Journal of clinical oncology (20.02.2020)
Published in Journal of clinical oncology (20.02.2020)
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Phase Ib study of niraparib plus androgen receptor-targeted therapy (ART) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
Saad, Fred, Chi, Kim N., Shore, Neal D., Graff, Julie Nicole, Posadas, Edwin M., Espina, Byron M., Zhu, Eugene, Hazra, Anasuya, Bradic, Branislav, Cheng, Shinta, Hayreh, Vinny, Rezazadeh, Arash
Published in Journal of clinical oncology (20.02.2020)
Published in Journal of clinical oncology (20.02.2020)
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Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design
Nooka, Ajay K, Weisel, Katja, van de Donk, Niels Wcj, Routledge, David, Otero, Paula Rodriguez, Song, Kevin, Quach, Hang, Callander, Natalie, Minnema, Monique C, Trudel, Suzanne, Jackson, Nicola A, Ahlers, Christoph M, Im, Ellie, Cheng, Shinta, Smith, L, Hareth, Nahi, Ferron-Brady, Geraldine, Brouch, Maria, Montes de Oca, Rocio, Paul, Sofia, Holkova, Beata, Gupta, Ira, Kremer, Brandon E, Richardson, Paul
Published in Future oncology (London, England) (01.06.2021)
Published in Future oncology (London, England) (01.06.2021)
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Synergistic effects of low-dose belantamab mafodotin in combination with a gamma-secretase inhibitor (nirogacestat) in patients with relapsed/refractory multiple myeloma (RRMM): DREAMM-5 study
Lonial, Sagar, Grosicki, Sebastian, Hus, Marek, Song, Kevin W., Facon, Thierry, Callander, Natalie Scott, Ribrag, Vincent, Uttervall, Katarina, Quach, Hang, Vorobyev, Vladimir I., Min, Chang Ki, Cheng, Shinta, Smith, L. Mary, Yu, Jing, Collingwood, Therese, Holkova, Beata, Kremer, Brandon, Gupta, Ira, Richardson, Paul G., Minnema, Monique C.
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2022)
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2022)
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