RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy
Chen, Han-Jou, Topp, Simon D, Hui, Ho Sang, Zacco, Elsa, Katarya, Malvika, McLoughlin, Conor, King, Andrew, Smith, Bradley N, Troakes, Claire, Pastore, Annalisa, Shaw, Christopher E
Published in Brain (London, England : 1878) (01.12.2019)
Published in Brain (London, England : 1878) (01.12.2019)
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Journal Article
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
Scotter, Emma L, Vance, Caroline, Nishimura, Agnes L, Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C, Rogelj, Boris, Rubinsztein, David C, Shaw, Christopher E
Published in Journal of cell science (15.03.2014)
Published in Journal of cell science (15.03.2014)
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Journal Article
Mechanisms of TDP-43 Proteinopathy Onset and Propagation
Chen, Han-Jou, Mitchell, Jacqueline C.
Published in International journal of molecular sciences (02.06.2021)
Published in International journal of molecular sciences (02.06.2021)
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Journal Article
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
Chen, Han-Jou, Mitchell, Jacqueline C, Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L, Scotter, Emma L, Vance, Caroline A, Cheetham, Michael E, Shaw, Christopher E
Published in Brain (London, England : 1878) (01.05.2016)
Published in Brain (London, England : 1878) (01.05.2016)
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Journal Article
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Lee, Youn-Bok, Chen, Han-Jou, Peres, João N., Gomez-Deza, Jorge, Attig, Jan, Štalekar, Maja, Troakes, Claire, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline, Adachi, Yoshitsugu, Sardone, Valentina, Miller, Jack W., Smith, Bradley N., Gallo, Jean-Marc, Ule, Jernej, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E.
Published in Cell reports (Cambridge) (01.12.2013)
Published in Cell reports (Cambridge) (01.12.2013)
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Journal Article
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Youn-Bok, Baskaran, Pranetha, Gomez-Deza, Jorge, Chen, Han-Jou, Nishimura, Agnes L, Smith, Bradley N, Troakes, Claire, Adachi, Yoshitsugu, Stepto, Alan, Petrucelli, Leonard, Gallo, Jean-Marc, Hirth, Frank, Rogelj, Boris, Guthrie, Sarah, Shaw, Christopher E
Published in Human molecular genetics (15.12.2017)
Published in Human molecular genetics (15.12.2017)
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Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase
Mitchell, John, Paul, Praveen, Chen, Han-Jou, Morris, Alex, Payling, Miles, Falchi, Mario, Habgood, James, Panoutsou, Stefania, Winkler, Sabine, Tisato, Veronica, Hajitou, Amin, Smith, Bradley, Vance, Caroline, Shaw, Christopher, Mazarakis, Nicholas D, de Belleroche, Jacqueline
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
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Journal Article
Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis
Chen, Han-Jou, Anagnostou, Georgia, Chai, Andrea, Withers, James, Morris, Alex, Adhikaree, Jason, Pennetta, Giuseppa, de Belleroche, Jackie S.
Published in The Journal of biological chemistry (17.12.2010)
Published in The Journal of biological chemistry (17.12.2010)
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Journal Article
Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
Chen, Jiun-Bo, PhD, James, Louisa K., PhD, Davies, Anna M., PhD, Wu, Yu-Chang Bryan, PhD, Rimmer, Joanne, FRCS, Lund, Valerie J., MS, FRCS, Chen, Jou-Han, MS, McDonnell, James M., PhD, Chan, Yih-Chih, PhD, Hutchins, George H., BSci, Chang, Tse Wen, PhD, Sutton, Brian J., DPhil, Kariyawasam, Harsha H., FRCP, PhD, Gould, Hannah J., PhD
Published in Journal of allergy and clinical immunology (01.04.2017)
Published in Journal of allergy and clinical immunology (01.04.2017)
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Journal Article
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells
Nishimura, Agnes L, Shum, Carole, Scotter, Emma L, Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin
Wu, Vin-Cent, Young, Guang-Huar, Huang, Po-Hsun, Lo, Shyh-Chyi, Wang, Kuo-Chuan, Sun, Chiao-Yin, Liang, Chan-Jung, Huang, Tao-Ming, Chen, Jou-Han, Chang, Fan-Chi, Chen, Yuh-Lien, Kuo, Yih-Shing, Chen, Jin-Bor, Chen, Jaw-Wen, Chen, Yung-Ming, Ko, Wen-Jo, Wu, Kwan-Dun
Published in Angiogenesis (London) (01.07.2013)
Published in Angiogenesis (London) (01.07.2013)
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Journal Article
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Sharp, Paul S, Akbar, Mohammed T, Bouri, Sonia, Senda, Atsushi, Joshi, Kieran, Chen, Han-Jou, Latchman, David S, Wells, Dominic J, de Belleroche, Jacqueline
Published in Neurobiology of disease (01.04.2008)
Published in Neurobiology of disease (01.04.2008)
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Journal Article
The molecular determinants of NEDD8 specific recognition by human SENP8
Shin, Yung-Cheng, Tang, Siao-Jing, Chen, Jou-Han, Liao, Pei-Han, Chang, Shih-Chung
Published in PloS one (14.11.2011)
Published in PloS one (14.11.2011)
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Journal Article
ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
de Majo, Martina, Topp, Simon D., Smith, Bradley N., Nishimura, Agnes L., Chen, Han-Jou, Gkazi, Athina Soragia, Miller, Jack, Wong, Chun Hao, Vance, Caroline, Baas, Frank, ten Asbroek, Anneloor L.M.A., Kenna, Kevin P., Ticozzi, Nicola, Redondo, Alberto Garcia, Esteban-Pérez, Jesús, Tiloca, Cinzia, Verde, Federico, Duga, Stefano, Morrison, Karen E., Shaw, Pamela J., Kirby, Janine, Turner, Martin R., Talbot, Kevin, Hardiman, Orla, Glass, Jonathan D., de Belleroche, Jacqueline, Gellera, Cinzia, Ratti, Antonia, Al-Chalabi, Ammar, Brown, Robert H., Silani, Vincenzo, Landers, John E., Shaw, Christopher E.
Published in Neurobiology of aging (01.11.2018)
Published in Neurobiology of aging (01.11.2018)
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Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response
Shih, Han-Po, Ding, Jing-Ya, Sotolongo Bellón, Junel, Lo, Yu-Fang, Chung, Pei-Han, Ting, He-Ting, Peng, Jhan-Jie, Wu, Tsai-Yi, Lin, Chia-Hao, Lo, Chia-Chi, Lin, You-Ning, Yeh, Chun-Fu, Chen, Jiun-Bo, Wu, Ting-Shu, Liu, Yuag-Meng, Kuo, Chen-Yen, Wang, Shang-Yu, Tu, Kun-Hua, Ng, Chau Yee, Lei, Wei-Te, Tsai, Yu-Huan, Chen, Jou-Han, Chuang, Ya-Ting, Huang, Jing-Yi, Rey, Félix A, Chen, Hung-Kai, Chang, Tse-Wen, Piehler, Jacob, Chi, Chih-Yu, Ku, Cheng-Lung
Published in The Journal of experimental medicine (05.09.2022)
Published in The Journal of experimental medicine (05.09.2022)
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Journal Article
Bispecific Antibody Binding To RANKL and Osteonectin with Enhanced Localization to the Bone
Chen, Jou-Han, Lin, Chun Yu, Chen, Yi-Chun Maria, Tian, Wei-Ting, Chu, Hsing-Mao, Chang, Tse Wen
Published in Molecular pharmaceutics (06.11.2017)
Published in Molecular pharmaceutics (06.11.2017)
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