Targeting the bradykinin B1 receptor to reduce pain
Chen, Jian Jeffrey, Johnson, Eileen J
Published in Expert opinion on therapeutic targets (01.01.2007)
Published in Expert opinion on therapeutic targets (01.01.2007)
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Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
Miner, Kent, Labitzke, Katja, Liu, Benxian, Wang, Paul, Henckels, Kathryn, Gaida, Kevin, Elliott, Robin, Chen, Jian Jeffrey, Liu, Longbin, Leith, Anh, Trueblood, Esther, Hensley, Kelly, Xia, Xing-Zhong, Homann, Oliver, Bennett, Brian, Fiorino, Mike, Whoriskey, John, Yu, Gang, Escobar, Sabine, Wong, Min, Born, Teresa L, Budelsky, Alison, Comeau, Mike, Smith, Dirk, Phillips, Jonathan, Johnston, James A, McGivern, Joseph G, Weikl, Kerstin, Powers, David, Kunzelmann, Karl, Mohn, Deanna, Hochheimer, Andreas, Sullivan, John K
Published in Frontiers in pharmacology (14.02.2019)
Published in Frontiers in pharmacology (14.02.2019)
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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L. Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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코로나바이러스 감염 치료용 프로테아제 억제제들
NAZARIAN ARMEN, MAZUMDAR WRICKBAN, GRABOVYI GENNADII, OKWOR NEECHI, ROGERS THOMAS F, JOSEPH SEAN, RIVA LAURA, GHORAI SOURAV, LIU YUYIN, GUPTA ANIL KUMAR, MALVIN JACQUELINE, CHATTERJEE ARNAB K, BAKOWSKI MALINA A, WILSON KATY, WEISS FRANK, WOLFF KAREN, WOODS ASHLEY, CHEN JIAN JEFFREY, RAHIMI ALIREZA, LI SHUANGWEI, SONG LIRUI, NAKATH ELSHAN, PEDROARENA JAMES, MCNAMARA CASE W
Year of Publication 15.03.2024
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Year of Publication 15.03.2024
Patent
Discovery of a Covalent Inhibitor of KRAS(G12C) (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A., Allen, Jennifer R., Allen, John G., Amegadzie, Albert K., Ashton, Kate S., Booker, Shon K., Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J., Goodman, Guy, Kopecky, David J., Liu, Longbin, Lopez, Patricia, Low, Jonathan D., Ma, Vu, Minatti, Ana E., Nguyen, Thomas T., Nishimura, Nobuko, Pickrell, Alexander J., Reed, Anthony B., Shin, Youngsook, Siegmund, Aaron C., Tamayo, Nuria A., Tegley, Christopher M., Walton, Mary C., Wang, Hui-Ling, Wurz, Ryan P., Xue, May, Yang, Kevin C., Achanta, Pragathi, Bartberger, Michael D., Canon, Jude, Hollis, L. Steven, McCarter, John D., Mohr, Christopher, Rex, Karen, Saiki, Anne Y., San Miguel, Tisha, Volak, Laurie P., Wang, Kevin H., Whittington, Douglas A., Zech, Stephan G., Lipford, J. Russell, Cee, Victor J.
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
KIF18A 억제제
BANERJEE ABHISEK, BOURBEAU MATTHEW PAUL, LI KEXUE, BROWN JAMES ALEXANDER, WALTON MARY CATHERINE, JIA LEI, TAMAYO NURIA A, CHEN JIAN JEFFREY, LOW JONATHAN DANTE, LIU QINGYIAN, FROHN MICHAEL J, PETTUS LIPING H, MA VU, MINATTI ANA ELENA
Year of Publication 30.08.2021
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Year of Publication 30.08.2021
Patent
Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair
Shao, Sida, Zhang, Nan, Specht, Gregory P, You, Shaochen, Song, Lirui, Fu, Qiangwei, Huang, David, You, Hengyao, Shu, Jian, Domissy, Alain, Li, Shuangwei, Nguyen-Tran, Van, Joseph, Sean B, Chatterjee, Arnab K, Chen, Jeffrey Jian, Schultz, Peter G, Bollong, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2024)
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Pharmacological YAP activation promotes regenerative repair of cutaneous wounds
Grzelak, Edyta M, Elshan, N G R Dayan, Shao, Sida, Bulos, Maya L, Joseph, Sean B, Chatterjee, Arnab K, Chen, Jian Jeffrey, Nguyên-Trân, Vân, Schultz, Peter G, Bollong, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2023)
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Journal Article
Regioselective synthesis of multiply halogenated azaxanthones
Qian, Wenyuan, Brown, James, Chen, Jian Jeffrey, Cheng, Yuan
Published in Tetrahedron letters (24.12.2014)
Published in Tetrahedron letters (24.12.2014)
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Journal Article
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
Tamayo, Nuria A, Bourbeau, Matthew P, Allen, Jennifer R, Ashton, Kate S, Chen, Jian Jeffrey, Kaller, Matthew R, Nguyen, Thomas T, Nishimura, Nobuko, Pettus, Liping H, Walton, Mary, Belmontes, Brian, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Hanestad, Kelly, Chung, Grace, Ninniri, Maria Stefania S, Sun, Jan, Poppe, Leszek, Spahr, Chris, Hui, John, Jia, Lei, Wu, Tian, Dahal, Upendra P, Edson, Katheryne Z, Payton, Marc
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead
Dayan Elshan, N. G. R., Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Correction to “Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead”
Elshan, N. G. R. Dayan, Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Liu, Dongdong, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Abstract 4455: Discovery of AMG 510, a first-in-human covalent inhibitor of KRASG12C for the treatment of solid tumors
Lanman, Brian A., Chen, Jian Jeffrey, Liu, Longbin, Lopez, Patricia, Pickrell, Alexander J., Reed, Anthony B., Wang, Hui-Ling, Achanta, Pragathi, Canon, Jude, Erlanson, Daniel A., Fucini, Raymond V., Jeong, Joon Won, Mohr, Christopher, Saiki, Anne Y., Cee, Victor J., Lipford, J. Russell, Rex, Karen, Volak, Laurie P.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Reversible cyclopropyl ring opening of 1-aroyl-2-phenylcyclopropane radical anions. Determination of the ring opening and closure rates of the intermediate ketyls
Tanner, Dennis D, Chen, Jian Jeffrey, Luelo, Christine, Peters, Pollyanna M
Published in Journal of the American Chemical Society (01.01.1992)
Published in Journal of the American Chemical Society (01.01.1992)
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease
Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities
Cheng, Yuan, Brown, James, Judd, Ted C, Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S, Chen, Jian Jeffrey, Bartberger, Michael D, Chen, Kui, Dunn, Robert T, Epstein, Oleg, Fremeau, Robert T, Harried, Scott, Hickman, Dean, Hitchcock, Stephen A, Luo, Yi, Minatti, Ana Elena, Patel, Vinod F, Vargas, Hugo M, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, White, Ryan D, Whittington, Douglas A, Zheng, Xiao Mei, Wood, Stephen
Published in ACS medicinal chemistry letters (12.02.2015)
Published in ACS medicinal chemistry letters (12.02.2015)
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