Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450
Brewer, Christopher Trent, Chen, Taosheng
Published in International journal of molecular sciences (08.11.2017)
Published in International journal of molecular sciences (08.11.2017)
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BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
Llambi, Fabien, Wang, Yue-Ming, Victor, Bernadette, Yang, Mao, Schneider, Desiree M., Gingras, Sébastien, Parsons, Melissa J., Zheng, Janet H., Brown, Scott A., Pelletier, Stéphane, Moldoveanu, Tudor, Chen, Taosheng, Green, Douglas R.
Published in Cell (07.04.2016)
Published in Cell (07.04.2016)
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Role of CAR and PXR in xenobiotic sensing and metabolism
Wang, Yue-Ming, Ong, Su Sien, Chai, Sergio C, Chen, Taosheng
Published in Expert opinion on drug metabolism & toxicology (01.07.2012)
Published in Expert opinion on drug metabolism & toxicology (01.07.2012)
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Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran
Published in Angewandte Chemie International Edition (13.12.2021)
Published in Angewandte Chemie International Edition (13.12.2021)
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Journal Article
SPA70 is a potent antagonist of human pregnane X receptor
Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng
Published in Nature communications (29.09.2017)
Published in Nature communications (29.09.2017)
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Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery
Lolodi, Ogheneochukome, Wang, Yue-Ming, Wright, William C, Chen, Taosheng
Published in Current drug metabolism (01.01.2017)
Published in Current drug metabolism (01.01.2017)
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Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70
Li, Yongtao, Lin, Wenwei, Wright, William C, Chai, Sergio C, Wu, Jing, Chen, Taosheng
Published in Journal of medicinal chemistry (11.02.2021)
Published in Journal of medicinal chemistry (11.02.2021)
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Journal Article
Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk
Oladimeji, Peter, Cui, Hongmei, Zhang, Chen, Chen, Taosheng
Published in Expert opinion on drug metabolism & toxicology (01.09.2016)
Published in Expert opinion on drug metabolism & toxicology (01.09.2016)
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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
Huber, Andrew D., Wright, William C., Lin, Wenwei, Majumder, Kinjal, Low, Jonathan A., Wu, Jing, Buchman, Cameron D., Pintel, David J., Chen, Taosheng
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
Garcia-Maldonado, Efren, Huber, Andrew D., Chai, Sergio C., Nithianantham, Stanley, Li, Yongtao, Wu, Jing, Poudel, Shyaron, Miller, Darcie J., Seetharaman, Jayaraman, Chen, Taosheng
Published in Nature communications (14.05.2024)
Published in Nature communications (14.05.2024)
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CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
Teitz, Tal, Fang, Jie, Goktug, Asli N, Bonga, Justine D, Diao, Shiyong, Hazlitt, Robert A, Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A, Taylor, Michael R, Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F, Kriwacki, Richard, Guy, R Kiplin, Chen, Taosheng, Zuo, Jian
Published in The Journal of experimental medicine (02.04.2018)
Published in The Journal of experimental medicine (02.04.2018)
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