Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists
Mercer, Stephen E., Chaturvedula, Prasad V., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Pin, Sokhom S., Macci, Robert, Schartman, Richard, Signor, Laura J., Widmann, Kimberly A., Whiterock, Valerie J., Chen, Ping, Xu, Cen, Herbst, John J., Kostich, Walter A., Thalody, George, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
Chaturvedula, Prasad V., Mercer, Stephen E., Pin, Sokhom S., Thalody, George, Xu, Cen, Conway, Charlie M., Keavy, Deborah, Signor, Laura, Cantor, Glenn H., Mathias, Neil, Moench, Paul, Denton, Rex, Macci, Robert, Schartman, Richard, Whiterock, Valerie, Davis, Carl, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Journal Article
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor
Chaturvedula, Prasad V., Pin, Sokhom, Tholady, George, Conway, Charlie M., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Journal Article
Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure
Degnan, Andrew P, Chaturvedula, Prasad V, Conway, Charles M, Cook, Deborah A, Davis, Carl D, Denton, Rex, Han, Xiaojun, Macci, Robert, Mathias, Neil R, Moench, Paul, Pin, Sokhom S, Ren, Shelly X, Schartman, Richard, Signor, Laura J, Thalody, George, Widmann, Kimberly A, Xu, Cen, Macor, John E, Dubowchik, Gene M
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Enantioselective synthesis of constrained phenylalanine analogues
Chaturvedula, Prasad V., Mercer, Stephen E., Guernon, Leatte, Macor, John E., Dubowchik, Gene M.
Published in Tetrahedron letters (20.10.2010)
Published in Tetrahedron letters (20.10.2010)
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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1
Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Macci, Robert, Pin, Sokhom S., Ren, Shelly X., Schartman, Richard, Signor, Laura J., Thalody, George, Widmann, Kimberly A., Xu, Cen, Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Journal Article
Catalytic Asymmetric Syntheses of Tyrosine Surrogates
Han, Xiaojun, Civiello, Rita L, Fang, Haiquang, Wu, Dedong, Gao, Qi, Chaturvedula, Prasad V, Macor, John E, Dubowchik, Gene M
Published in Journal of organic chemistry (07.11.2008)
Published in Journal of organic chemistry (07.11.2008)
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Journal Article
CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS
CHATURVEDULA PRASAD V, POINDEXTER GRAHAM, HAN XIAOJUN, DEGNAN ANDREW P, KARAGEORGE GEORGE N, LUO GUANGLIN, CONWAY CHARLES MARK, CIVIELLO RITA, MACOR JOHN E, CHEN LING, DUBOWCHIK GENE M, VIG SHIKHA
Year of Publication 12.01.2012
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Year of Publication 12.01.2012
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