Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, Maccormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R
Published in Nature chemical biology (13.04.2011)
Published in Nature chemical biology (13.04.2011)
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Journal Article
Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R
Published in Oncotarget (30.07.2014)
Published in Oncotarget (30.07.2014)
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Journal Article
Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
The discovery of the potent aurora inhibitor MK-0457 (VX-680)
Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Journal Article
Synthesis and evaluation of novel prodrugs of caspase inhibitors
Charrier, Jean-Damien, Durrant, Steven J., Studley, John, Lawes, Linda, Weber, Peter
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Rational Design of 5‑(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor
Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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Journal Article
Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors
Charrier, Jean-Damien, Miller, Andrew, Kay, David P, Brenchley, Guy, Twin, Heather C, Collier, Philip N, Ramaya, Sharn, Keily, Shazia B, Durrant, Steven J, Knegtel, Ronald M. A, Tanner, Adam J, Brown, Kieron, Curnock, Adam P, Jimenez, Juan-Miguel
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Synthesis, Structural and Biological Studies of Ubiquitin Mutants Containing (2S, 4S)-5-Fluoroleucine Residues Strategically Placed in the Hydrophobic Core
Alexeev, Dmitriy, Barlow, Paul N, Bury, Stella M, Charrier, Jean-Damien, Cooper, Alan, Hadfield, David, Jamieson, Craig, Kelly, Sharon M, Layfield, Robert, Mayer, R. John, McSparron, Helen, Price, Nicholas C, Ramage, Robert, Sawyer, Lindsay, Starkmann, Bernard A, Uhrin, Dusan, Wilken, Jill, Young, Douglas W
Published in Chembiochem : a European journal of chemical biology (05.09.2003)
Published in Chembiochem : a European journal of chemical biology (05.09.2003)
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Journal Article
Advances in the design of ITK inhibitors
Charrier, Jean-Damien, Knegtel, Ronald M A
Published in Expert opinion on drug discovery (01.04.2013)
Published in Expert opinion on drug discovery (01.04.2013)
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Journal Article
GCN2 INHIBITORS AND USES THEREOF
MATTHEW BLEICH, STEVEN DURRANT, EVERITT SIMON, ROBERT PULLIN, IGOR MOCHALKIN, FILIPPOS PORICHIS, GORKA ETXEBARRIA I JARDI, QIU HUI, DONG HUIJUN, MEREDITH SUZANNE ENO, PIERRE-HENRI STORCK, CHARRIER JEAN-DAMIEN, XIAO YUFANG, KNEGTEL RONALD, HEATHER CLARE TWIN, FRAYSSE DAMIEN, KIRI NORTH
Year of Publication 14.12.2023
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Year of Publication 14.12.2023
Patent
From benzil arylimines to 2H-benzo-1,4-thiazines, benzothiazoles or indoles
Charrier, JD, Landreau, C, Deniaud, D, Reliquet, F, Reliquet, A, Meslin, JC
Published in Tetrahedron (07.05.2001)
Published in Tetrahedron (07.05.2001)
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Journal Article
PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE
STEVEN DURRANT, MORTIMORE MICHAEL, JOANNE PINDER, ALISTAIR RUTHERFORD, PHILIP MICHAEL REAPER, O'DONNELL MICHAEL, KAY DAVID, ANISA NIZARALI VIRANI, CHARRIER JEAN-DAMIEN, SOMHAIRLE MACCORMICK, YOUNG STEVEN, KNEGTEL RONALD
Year of Publication 07.11.2019
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Year of Publication 07.11.2019
Patent
GCN2 억제제 및 이의 용도
EVERITT SIMON, ENO MEREDITH SUZANNE, ETXEBARRIA I JARDI GORKA, STORCK PIERRE HENRI, QIU HUI, TWIN HEATHER CLARE, BLEICH MATTHEW, DONG HUIJUN, NORTH KIRI, DURRANT STEVEN, CHARRIER JEAN DAMIEN, PORICHIS FILIPPOS, MOCHALKIN IGOR, XIAO YUFANG, KNEGTEL RONALD, FRAYSSE DAMIEN, PULLIN ROBERT
Year of Publication 07.10.2020
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Year of Publication 07.10.2020
Patent