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Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2012)
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Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N, Kaminsky, Werner, Charman, Susan A, Matthews, David, Rathod, Pradipsinh K, Phillips, Margaret A
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
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Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
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Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W, Jones-Brando, Lorraine, Yolken, Robert H, Bordón, Claudia, Charman, Susan A, Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N, Hinrichs, David J, Meunier, Brigitte, Carruthers, Vern B, Riscoe, Michael K
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
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System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
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Published in PLoS pathogens (01.06.2020)
Published in PLoS pathogens (01.06.2020)
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Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials
Creek, Darren J, Charman, William N, Chiu, Francis C K, Prankerd, Richard J, Dong, Yuxiang, Vennerstrom, Jonathan L, Charman, Susan A
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage
Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Chatelain, Eric, Kelly, John M.
Published in Scientific reports (17.10.2016)
Published in Scientific reports (17.10.2016)
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An in vitro toolbox to accelerate anti-malarial drug discovery and development
Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada
Published in Malaria journal (02.01.2020)
Published in Malaria journal (02.01.2020)
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Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials
Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis C. K, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Crespo, Benigno, Sanz, Laura M, Wang, Binglin, Wittlin, Sergio, Charman, Susan A, Avery, Vicky M, Cho, Nobuo, Kamaura, Masahiro
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers
Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials
Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M, Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A, Yeates, Clive, Gilbert, Ian H
Published in Journal of medicinal chemistry (11.04.2013)
Published in Journal of medicinal chemistry (11.04.2013)
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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential
Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J.
Published in Nature communications (01.03.2017)
Published in Nature communications (01.03.2017)
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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones
Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L, Shackleford, David M, O'Loughlin, Kathleen G, Charman, Susan A, Mirsalis, Jon C, Guy, R Kiplin
Published in Malaria journal (19.02.2021)
Published in Malaria journal (19.02.2021)
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Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase
Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans
Trevaskis, Natalie L., Lee, Given, Escott, Alistair, Phang, Kian Liun, Hong, Jiwon, Cao, Enyuan, Katneni, Kasiram, Charman, Susan A., Han, Sifei, Charman, William N., Phillips, Anthony R. J., Windsor, John A., Porter, Christopher J. H.
Published in Frontiers in physiology (21.05.2020)
Published in Frontiers in physiology (21.05.2020)
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On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
Edgar, Rebecca C S, Malcolm, Tess R, Siddiqui, Ghizal, Giannangelo, Carlo, Counihan, Natalie A, Challis, Matthew, Duffy, Sandra, Chowdhury, Mrittika, Marfurt, Jutta, Dans, Madeline, Wirjanata, Grennady, Noviyanti, Rintis, Daware, Kajal, Suraweera, Chathura D, Price, Ric N, Wittlin, Sergio, Avery, Vicky M, Drinkwater, Nyssa, Charman, Susan A, Creek, Darren J, de Koning-Ward, Tania F, Scammells, Peter J, McGowan, Sheena
Published in mBio (12.06.2024)
Published in mBio (12.06.2024)
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Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides
Russell, Stephanie, Rahmani, Raphaël, Jones, Amy J, Newson, Harriet L, Neilde, Kevin, Cotillo, Ignacio, Rahmani Khajouei, Marzieh, Ferrins, Lori, Qureishi, Sana, Nguyen, Nghi, Martinez-Martinez, Maria S, Weaver, Donald F, Kaiser, Marcel, Riley, Jennifer, Thomas, John, De Rycker, Manu, Read, Kevin D, Flematti, Gavin R, Ryan, Eileen, Tanghe, Scott, Rodriguez, Ana, Charman, Susan A, Kessler, Albane, Avery, Vicky M, Baell, Jonathan B, Piggott, Matthew J
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Journal Article
Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp
Davis, Rohan A, Buchanan, Malcolm S, Duffy, Sandra, Avery, Vicky M, Charman, Susan A, Charman, William N, White, Karen L, Shackleford, David M, Edstein, Michael D, Andrews, Katherine T, Camp, David, Quinn, Ronald J
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
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