Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamics results of a long‐acting C‐type natriuretic peptide prodrug, TransCon CNP
Breinholt, Vibeke Miller, Mygind, Per Holse, Christoffersen, Eva Dam, Zhang, Ying, Ota, Sho, Will Charlton, R., Viuff, Dorthe
Published in British journal of clinical pharmacology (01.11.2022)
Published in British journal of clinical pharmacology (01.11.2022)
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Journal Article
Assessing physical symptoms, daily functioning, and well‐being in children with achondroplasia
Pfeiffer, Kathryn M., Brod, Meryl, Smith, Alden, Gianettoni, Jill, Viuff, Dorthe, Ota, Sho, Charlton, R. Will
Published in American journal of medical genetics. Part A (01.01.2021)
Published in American journal of medical genetics. Part A (01.01.2021)
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Journal Article
Assessing the impacts of having a child with achondroplasia on parent well-being
Pfeiffer, Kathryn M., Brod, Meryl, Smith, Alden, Gianettoni, Jill, Viuff, Dorthe, Ota, Sho, Charlton, R. Will
Published in Quality of life research (01.01.2021)
Published in Quality of life research (01.01.2021)
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Journal Article
The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers
Rosenstock, Moti, Tseng, Leo, Pierce, Andrew A, Offman, Elliot, Chen, Chao-Yin, Charlton, R Will, Margalit, Maya, Mansbach, Hank
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
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Journal Article
Population Pharmacokinetics and Pharmacodynamics of Pegozafermin in Patients with Nonalcoholic Steatohepatitis
Tseng, Chih-Ming Leo, Balic, Kemal, Charlton, R Will, Margalit, Maya, Mansbach, Hank, Savic, Rada M
Published in Clinical pharmacology and therapeutics (01.12.2023)
Published in Clinical pharmacology and therapeutics (01.12.2023)
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Safety, pharmacokinetics, and pharmacodynamics of pegozafermin in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 1b/2a multiple-ascending-dose study
Loomba, Rohit, Lawitz, Eric J, Frias, Juan Pablo, Ortiz-Lasanta, Grisell, Johansson, Lars, Franey, Bridgette Boggess, Morrow, Linda, Rosenstock, Moti, Hartsfield, Cynthia L, Chen, Chao-Yin, Tseng, Leo, Charlton, R Will, Mansbach, Hank, Margalit, Maya
Published in The lancet. Gastroenterology & hepatology (01.02.2023)
Published in The lancet. Gastroenterology & hepatology (01.02.2023)
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Pharmacokinetic (PK) and pharmacodynamics (PD) of BIO89-100, a novel glycoPEGylated FGF21, in non-alcoholic steatohepatitis (NASH) patients with compensated cirrhosis
Alkhouri, Naim, Charlton, Will, Mansbach, Hank, Margalit, Maya, Balic, Kemal, Tseng, Leo
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Pegozafermin led to significant metabolic benefits, in addition to robust beneficial effects on the liver, in an open-label cohort of a Phase 1b/2a study in subjects with non-alcoholic steatohepatitis (NASH)
Alkhouri, Naim, Loomba, Rohit, Frias, Juan P, Morrow, Linda, Feng, Shibao, Tseng, Leo, Agollah, Germaine D., Charlton, Will, Mansbach, Hank, Margalit, Maya, Harrison, Stephen
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Pegozafermin improved liver histology, liver-related non-invasive tests (NITs) and metabolic profiles in an open-label cohort of a Phase 1b/2a study in subjects with non-alcoholic steatohepatitis (NASH)
Loomba, Rohit, Alkhouri, Naim, Lazas, Don, Bedossa, Pierre, Morrow, Linda, Feng, Shibao, Tseng, Leo, Agollah, Germaine D., Charlton, Will, Mansbach, Hank, Margalit, Maya, Harrison, Stephen
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
RF32 | PSUN58 BIO89-100 Treatment Ameliorates a Subclinical Increase in Spleen Volume in Non-cirrhotic NASH in Correlation With Change in Liver Fat, HOMA-IR and Inflammatory Markers in a Phase 1b/2a, Placebo-Controlled, Double-Blind Proof of Concept Study
Frias, Juan, Johansson, Lars, Will Charlton, R, Feng, Shibao, Agollah, Germaine D, Mansbach, Hank, Margalit, Maya
Published in Journal of the Endocrine Society (01.11.2022)
Published in Journal of the Endocrine Society (01.11.2022)
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Journal Article
Experiences of Parents of Children with Achondroplasia: Impacts on Quality of Life
Smith, Alden, Pfeiffer, Kathryn M., Brod, Meryl, Bauri, Dianne, Viuff, Dorthe, Ota, Sho, Gianettoni, Jill, Charlton, Will
Published in Journal of pediatric nursing (01.05.2020)
Published in Journal of pediatric nursing (01.05.2020)
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Journal Article
Achondroplasia: Impacts on Children’s Functioning and Well-being
Smith, Alden, Pfeiffer, Kathryn M., Brod, Meryl, Bauri, Dianne, Viuff, Dorthe, Ota, Sho, Gianettoni, Jill, Charlton, Will
Published in Journal of pediatric nursing (01.05.2020)
Published in Journal of pediatric nursing (01.05.2020)
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Journal Article
016–Treatment Adherence to Somavaratan (VRS-317), a Long-Acting Growth Hormone for Children with Growth Hormone Deficiency (GHD): the VISTA Trial
Humphriss, Eric, Sheikh, F. Naureen, Seaman, Morgan, Ng, David, Di Trapani, Kelly, Charlton, Will
Published in Journal of pediatric nursing (01.05.2017)
Published in Journal of pediatric nursing (01.05.2017)
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Journal Article
017–Safety and Efficacy of Somavaratan (VRS-317), a Long-Acting Growth Hormone, in Children with Growth Hormone Deficiency (GHD): 2.5-Year Results from the VISTA Trial
Leutjen, Terri, Di Trapani, Kelly, Ng, David, Humphriss, Eric, Charlton, Will
Published in Journal of pediatric nursing (01.05.2017)
Published in Journal of pediatric nursing (01.05.2017)
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Prevalence of Nonalcoholic Fatty Liver Disease in Patients with Severe Hypertriglyceridemia (SHTG) – Initial Baseline data from an Ongoing Phase 2 Study
Bhatt, Deepak L., Kastelein, John J.P., Parli, Teresa, Charlton, R. Will, Hartsfield, Cynthia L., Feng, Shibao, Mansbach, Hank, Bays, Harold
Published in Metabolism, clinical and experimental (01.03.2022)
Published in Metabolism, clinical and experimental (01.03.2022)
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