A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Greenhalgh, Mark D., Smith, Samuel M., Walden, Daniel M., Taylor, James E., Brice, Zamira, Robinson, Emily R. T., Fallan, Charlene, Cordes, David B., Slawin, Alexandra M. Z., Richardson, H. Camille, Grove, Markas A., Cheong, Paul Ha‐Yeon, Smith, Andrew D.
Published in Angewandte Chemie International Edition (12.03.2018)
Published in Angewandte Chemie International Edition (12.03.2018)
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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W, Finlay, M. Raymond V, Ting, Attilla K. T, Beattie, David, Lamont, Gillian M, Fallan, Charlene, Wrigley, Gail L, Schimpl, Marianne, Howard, Martin R, Williamson, Beth, Vazquez-Chantada, Mercedes, Barratt, Derek G, Davies, Barry R, Cadogan, Elaine B, Ramos-Montoya, Antonio, Dean, Emma
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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A Buchwald–Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3‐Ligase PROTACs
Hayhow, Thomas G., Borrows, Rachel E. A., Diène, Coura R., Fairley, Gary, Fallan, Charlene, Fillery, Shaun M., Scott, James S., Watson, David W.
Published in Chemistry : a European journal (15.12.2020)
Published in Chemistry : a European journal (15.12.2020)
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Stereospecific Asymmetric N‑Heterocyclic Carbene (NHC)-Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights
Davies, Alyn T, Taylor, James E, Douglas, James, Collett, Christopher J, Morrill, Louis C, Fallan, Charlene, Slawin, Alexandra M. Z, Churchill, Gwydion, Smith, Andrew D
Published in Journal of organic chemistry (20.09.2013)
Published in Journal of organic chemistry (20.09.2013)
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Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
Jeffries, Benjamin, Wang, Zhong, Troup, Robert I, Goupille, Anaïs, Le Questel, Jean-Yves, Fallan, Charlene, Scott, James S, Chiarparin, Elisabetta, Graton, Jérôme, Linclau, Bruno
Published in Beilstein journal of organic chemistry (02.09.2020)
Published in Beilstein journal of organic chemistry (02.09.2020)
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Enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofurans using a Bronsted base/thiourea bifunctional catalyst
Antunez, Diego-Javier Barrios, Greenhalgh, Mark D., Fallan, Charlene, Slawin, Alexandra M. Z., Smith, Andrew D.
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Current strategies for the design of PROTAC linkers: a critical review
Troup, Robert I., Fallan, Charlene, Baud, Matthias G. J.
Published in Exploration of targeted anti-tumor therapy (11.10.2020)
Published in Exploration of targeted anti-tumor therapy (11.10.2020)
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Ytterbium-Catalyzed Conjugate Allylation of Alkylidene Malonates
Fallan, Charlene, Quigley, Paul F, Lam, Hon Wai
Published in Journal of organic chemistry (20.05.2011)
Published in Journal of organic chemistry (20.05.2011)
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A C=O center dot center dot center dot Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Greenhalgh, Mark D., Smith, Samuel M., Walden, Daniel M., Taylor, James E., Brice, Zamira, Robinson, Emily R. T., Fallan, Charlene, Cordes, David B., Slawin, Alexandra M. Z., Richardson, H. Camille, Grove, Markas A., Cheong, Paul Ha-Yeon, Smith, Andrew D.
Published in Angewandte Chemie International Edition (12.03.2018)
Published in Angewandte Chemie International Edition (12.03.2018)
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Visible Light‐Mediated Cyclisation Reaction for the Synthesis of Highly‐Substituted Tetrahydroquinolines and Quinolines
Sherborne, Grant J., Kemmitt, Paul, Prentice, Callum, Zysman‐Colman, Eli, Smith, Andrew D., Fallan, Charlene
Published in Angewandte Chemie International Edition (09.01.2023)
Published in Angewandte Chemie International Edition (09.01.2023)
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Journal Article
Non-bonding 1,5-S•••O interactions govern chemo- and enantioselectivity in isothiourea-catalyzed annulations of benzazoles
Robinson, Emily R. T., Walden, Daniel M., Fallan, Charlene, Greenhalgh, Mark D., Cheong, Paul Ha-Yeon, Smith, Andrew D.
Published in Chemical science (Cambridge) (01.01.2016)
Published in Chemical science (Cambridge) (01.01.2016)
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The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W, Finlay, M Raymond V, Ting, Attilla K T, Beattie, David, Lamont, Gillian M, Fallan, Charlene, Wrigley, Gail L, Schimpl, Marianne, Howard, Martin R, Williamson, Beth, Vazquez-Chantada, Mercedes, Barratt, Derek G, Davies, Barry R, Cadogan, Elaine B, Ramos-Montoya, Antonio, Dean, Emma
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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Structural and Physicochemical Features of Oral PROTACs
Schade, Markus, Scott, James S., Hayhow, Thomas G., Pike, Andy, Terstiege, Ina, Ahlqvist, Marie, Johansson, Johan R., Diene, Coura R., Fallan, Charlene, Balazs, Amber Y. S., Chiarparin, Elisabetta, Wilson, David
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer
Bagal, Sharan K., Astles, Peter C., Diène, Coura, Argyrou, Argyrides, Crafter, Claire, Cassar, Doyle J., Fallan, Charlene, Hock, Andreas, Jones, Thomas, Moreau, Kevin, Lamont, Gillian M., Lamont, Scott, Michaloglou, Chrysiis, Packer, Martin J., Pike, Andy, Ramos-Montoya, Antonio, Scott, James S., Shaw, Joseph, Shologu, Ziyanda
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
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Journal Article
α‑Ketophosphonates as Ester Surrogates: Isothiourea-Catalyzed Asymmetric Diester and Lactone Synthesis
Smith, Siobhan R., Leckie, Stuart M., Holmes, Reuben, Douglas, James, Fallan, Charlene, Shapland, Peter, Pryde, David, Slawin, Alexandra M. Z., Smith, Andrew D.
Published in Organic letters (02.05.2014)
Published in Organic letters (02.05.2014)
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Abstract DDT01-02: Discovery and first structural disclosure of AZD7648: A potent and selective DNA-PK inhibitor
Goldberg, Frederick W., Cadogan, Elaine, Finlay, Raymond, Montoya, Antonio Ramos, Beattie, David, Lamont, Gillian, Fallan, Charlene, Fok, Jacqueline, Vazquez-Chantada, Mercedes, Barratt, Derek, Dean, Emma, Norris, Jane, Campbell, Andrew, Cronin, Anna, Harding, Joanna, Ting, Attilla, Hollingsworth, Simon, Davies, Barry
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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