Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy
Chari, Ravi V. J., Miller, Michael L., Widdison, Wayne C.
Published in Angewandte Chemie International Edition (07.04.2014)
Published in Angewandte Chemie International Edition (07.04.2014)
Get full text
Journal Article
Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates
Zhao, Robert Y, Wilhelm, Sharon D, Audette, Charlene, Jones, Gregory, Leece, Barbara A, Lazar, Alexandru C, Goldmacher, Victor S, Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C, Lambert, John M, Chari, Ravi V. J
Published in Journal of medicinal chemistry (26.05.2011)
Published in Journal of medicinal chemistry (26.05.2011)
Get full text
Journal Article
Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage
Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J
Published in Bioconjugate chemistry (20.04.2011)
Published in Bioconjugate chemistry (20.04.2011)
Get full text
Journal Article
Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Li, Wei, Veale, Karen H, Qiu, Qifeng, Sinkevicius, Kerstin W, Maloney, Erin K, Costoplus, Juliet A, Lau, Janet, Evans, Helen L, Setiady, Yulius, Ab, Olga, Abbott, Stephen M, Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A, Chari, Ravi V. J, Widdison, Wayne C
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
Get full text
Journal Article
Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate
REDDY, Joseph A, WESTRICK, Elaine, SANTHAPURAM, Hari K. R, HOWARD, Stephen J, MILLER, Michael L, VETZEL, Marilynn, VLAHOV, Iontcho, CHARI, Ravi V. J, GOLDMACHER, Victor S, LEAMON, Christopher P
Published in Cancer research (Chicago, Ill.) (01.07.2007)
Published in Cancer research (Chicago, Ill.) (01.07.2007)
Get full text
Journal Article
Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers
Salomon, Paulin L, Reid, Emily E, Archer, Katie E, Harris, Luke, Maloney, Erin K, Wilhelm, Alan J, Miller, Michael L, Chari, Ravi V. J, Keating, Thomas A, Singh, Rajeeva
Published in Molecular pharmaceutics (02.12.2019)
Published in Molecular pharmaceutics (02.12.2019)
Get full text
Journal Article
Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance
KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Get full text
Journal Article
A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity
Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J
Published in Molecular cancer therapeutics (01.08.2016)
Published in Molecular cancer therapeutics (01.08.2016)
Get full text
Journal Article
Antibody–Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of Indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells
Singh, Rajeeva, Reid, Emily E, Harris, Luke, Salomon, Paulin L, Miller, Michael L, Chari, Ravi V. J, Keating, Thomas A
Published in Molecular pharmaceutics (06.01.2020)
Published in Molecular pharmaceutics (06.01.2020)
Get full text
Journal Article
Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer
Widdison, Wayne C, Wilhelm, Sharon D, Cavanagh, Emily E, Whiteman, Kathleen R, Leece, Barbara A, Kovtun, Yelena, Goldmacher, Victor S, Xie, Hongsheng, Steeves, Rita M, Lutz, Robert J, Zhao, Robert, Wang, Lintao, Blättler, Walter A, Chari, Ravi V. J
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Journal Article
Synthesis and Biological Evaluation of Antibody Conjugates of Phosphate Prodrugs of Cytotoxic DNA Alkylators for the Targeted Treatment of Cancer
Zhao, Robert Yongxin, Erickson, Hans K, Leece, Barbara A, Reid, Emily E, Goldmacher, Victor S, Lambert, John M, Chari, Ravi V. J
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
Get full text
Journal Article
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs)
Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
Get full text
Journal Article
Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing
Widdison, Wayne C, Ponte, Jose F, Coccia, Jennifer A, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Hong, E. Erica, Wu, Rui, Qiu, Qifeng, Singh, Rajeeva, Salomon, Paulin, Fishkin, Nathan, Harris, Luke, Maloney, Erin K, Kovtun, Yelena, Veale, Karen, Wilhelm, Sharon D, Audette, Charlene A, Costoplus, Juliet A, Chari, Ravi V. J
Published in Bioconjugate chemistry (18.11.2015)
Published in Bioconjugate chemistry (18.11.2015)
Get full text
Journal Article
Synthesis of Highly Potent N‑10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody–Drug Conjugates (ADCs)
Archer, Katie E, Reid, Emily E, Shizuka, Manami, Woods, James, Harris, Luke, Maloney, Erin K, Bartle, Laura M, Ab, Olga, Wilhelm, Alan, Setiady, Yulius, Ponte, Jose F, Singh, Rajeeva, Keating, Thomas A, Chari, Ravi V. J, Miller, Michael L
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
Get full text
Journal Article
A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells
Singh, Rajeeva, Setiady, Yulius Y, Ponte, Jose, Kovtun, Yelena V, Lai, Katharine C, Hong, E Erica, Fishkin, Nathan, Dong, Ling, Jones, Gregory E, Coccia, Jennifer A, Lanieri, Leanne, Veale, Karen, Costoplus, Juliet A, Skaletskaya, Anna, Gabriel, Rabih, Salomon, Paulin, Wu, Rui, Qiu, Qifeng, Erickson, Hans K, Lambert, John M, Chari, Ravi V J, Widdison, Wayne C
Published in Molecular cancer therapeutics (01.06.2016)
Published in Molecular cancer therapeutics (01.06.2016)
Get full text
Journal Article
Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs)
Reid, Emily E, Archer, Katie E, Shizuka, Manami, Wilhelm, Alan, Yoder, Nicholas C, Bai, Chen, Fishkin, Nathan E, Harris, Luke, Maloney, Erin K, Salomon, Paulin, Hong, Erica, Wu, Rui, Ab, Olga, Jin, Shan, Lai, Katharine C, Sikka, Surina, Chari, Ravi V. J, Miller, Michael L
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
Get full text
Journal Article