Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity
Ackerman, Shelley E, Pearson, Cecelia I, Gregorio, Joshua D, Gonzalez, Joseph C, Kenkel, Justin A, Hartmann, Felix J, Luo, Angela, Ho, Po Y, LeBlanc, Heidi, Blum, Lisa K, Kimmey, Samuel C, Luo, Andrew, Nguyen, Murray L, Paik, Jason C, Sheu, Lauren Y, Ackerman, Benjamin, Lee, Arthur, Li, Hai, Melrose, Jennifer, Laura, Richard P, Ramani, Vishnu C, Henning, Karla A, Jackson, David Y, Safina, Brian S, Yonehiro, Grant, Devens, Bruce H, Carmi, Yaron, Chapin, Steven J, Bendall, Sean C, Kowanetz, Marcin, Dornan, David, Engleman, Edgar G, Alonso, Michael N
Published in Nature cancer (01.01.2021)
Published in Nature cancer (01.01.2021)
Get more information
Journal Article
The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates
Oshima, Shinsuke, Karrer, Erik E, Kawato, Yuka, Maeda, Masashi, Fukahori, Hidehiko, Tsujimoto, Susumu, Hirose, Jun, Nakamura, Koji, Marui, Takanori, Takamura, Fujiko, Noto, Takahisa, Chapin, Steven J, Fujii, Yasutomo, Neighbors, Margaret, Viswanathan, Sridhar, Devens, Bruce H, Higashi, Yasuyuki
Published in Transplantation (01.12.2016)
Published in Transplantation (01.12.2016)
Get more information
Journal Article
ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution
Oshima, Shinsuke, Karrer, Erik E., Paidhungat, Madan M., Neighbors, Margaret, Chapin, Steven J., Fan, Rong A., Reed, Margaret A., Wu, Kuoting, Wong, Clifford, Chen, Yonghong, Whitlow, Marc, Anderson, Francisco A., Bam, Rujuta A., Zhang, Qian, Larsen, Brent R., Viswanathan, Sridhar, Devens, Bruce H., Bass, Steven H., Higashi, Yasuyuki
Published in Protein engineering, design and selection (01.05.2016)
Published in Protein engineering, design and selection (01.05.2016)
Get full text
Journal Article
The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells
ter Beest, Martin B A, Chapin, Steven J, Avrahami, Dana, Mostov, Keith E
Published in Molecular biology of the cell (01.12.2005)
Published in Molecular biology of the cell (01.12.2005)
Get full text
Journal Article
Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys
Oshima, Shinsuke, Fujii, Yasutomo, Karrer, Erik E., Takamura, Fujiko, Chapin, Steven J., Neighbors, Margaret, Viswanathan, Sridhar, Devens, Bruce H., Higashi, Yasuyuki, Mizuhara, Hidekazu
Published in International immunopharmacology (01.11.2016)
Published in International immunopharmacology (01.11.2016)
Get full text
Journal Article
Reduced Immunoglobulin A Transcytosis Associated with Immunoglobulin A Nephropathy and Nasopharyngeal Carcinoma
Su, Tao, Chapin, Steven J., Bryant, David M., Shewan, Annette M., Young, Kitty, Mostov, Keith E.
Published in The Journal of biological chemistry (30.12.2011)
Published in The Journal of biological chemistry (30.12.2011)
Get full text
Journal Article
784 BDC-2034: discovery of a CEA-targeting immune-stimulating antibody conjugate (ISAC) for solid tumors
Mallet, William, Gadkari, Rishali, Pearson, Cecelia, Torrez Dulgeroff, Laughing Bear, Luo, Angela, Luo, AAngela Luondrew, Melrose, Jennifer, Nolin, Jess, Lee, Arthur, Zhou, Matthew, Anand, Puneet, Sarma, Ganapathy, Henning, Karla, Blum, Lisa, Chapin, Steven, Bogaert, Liz, Ackerman, Shelley, Kudirka, Romas, Shen, Yuyi, Husain, Amreen, Perez, Edith, Kowanetz, Marcin, Alonso, Michael, Safina, Brian, Dornan, David
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
Get full text
Journal Article
603 Covalent attachment of a TLR7/8 agonist to tumor-targeting antibodies drives potent anti-tumor efficacy by synergistically activating FcgR- and TLR- signaling and enables safe systemic administration
Ackerman, Shelley, Hartmann, Felix, Pearson, Cecelia, Gonzalez, Joseph, Ho, Po Yi, Kimmey, Samuel, Luo, Andrew, Ackerman, Benjamin, Lee, Arthur, Laura, Richard, Paik, Jason, Henning, Karla, Jackson, David, Chapin, Steven, Devens, Bruce, Dornan, David, Bendall, Sean, Engleman, Edgar, Alonso, Michael
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
Get full text
Journal Article
A Conserved Domain is Present in Different Families of Vesicular Fusion Proteins: A New Superfamily
Weimbs, Thomas, Low, Seng Hui, Chapin, Steven J., Mostov, Keith E., Bucher, Philipp, Hofmann, Kay
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1997)
Get full text
Journal Article
821 The combination of a trastuzumab ISAC and pertuzumab augments anti-tumor efficacy in multiple HER2+ tumor models relative to trastuzumab plus pertuzumab
Pearson, Cecelia I, Luo, Andrew, Henning, Karla A, Lucas, Anthony, Omstead, David, McEachin, Katelynn A, Ponath, Paul D, Chapin, Steven J, Ackerman, Shelley E, Perez, Edith A, Kim, Han K, Alonso, Michael N
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile
Kim, Han K, Monnier, Justin, Fu, Chi-Ling, Zhou, Matthew, Melrose, Jennifer E, Dao, Hung, Ponath, Paul D, McEachin, Katelynn A, Omstead, David T, Kreder, Cindy, Chun, Stefan, Lee, Ying Yueh, Grgich, Rachel, Lin, Tracey J, Walker, Joshua A, Henning, Karla A, Kudirka, Romas, Ackerman, Shelley E, Carrera, Diane, Chapin, Steven J, Mallet, William, Jackson, Dowdy, Gao, Changshou, Alonso, Michael N
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
Definition of Distinct Compartments in Polarized Madin–Darby Canine Kidney (MDCK) Cells for Membrane‐Volume Sorting, Polarized Sorting and Apical Recycling
Brown, Paul S., Wang, Exing, Aroeti, Benjamin, Chapin, Steven J., Mostov, Keith E., Dunn, Kenneth W.
Published in Traffic (Copenhagen, Denmark) (01.02.2000)
Published in Traffic (Copenhagen, Denmark) (01.02.2000)
Get full text
Journal Article
Apical and Basolateral Endocytic Pathways of MDCK Cells Meet in Acidic Common Endosomes Distinct from a Nearly‐Neutral Apical Recycling Endosome
Wang, Exing, Brown, Paul S., Aroeti, Benjamin, Chapin, Steven J., Mostov, Keith E., Dunn, Kenneth W.
Published in Traffic (Copenhagen, Denmark) (01.06.2000)
Published in Traffic (Copenhagen, Denmark) (01.06.2000)
Get full text
Journal Article
Apical targeting in polarized epithelial cells: There's more afloat than rafts
Weimbs, Thomas, Low, Seng Hui, Chapin, Steven J., Mostov, Keith E.
Published in Trends in cell biology (01.10.1997)
Published in Trends in cell biology (01.10.1997)
Get full text
Journal Article
Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth
Nguyen, H L, Chari, S, Gruber, D, Lue, C M, Chapin, S J, Bulinski, J C
Published in Journal of cell science (01.01.1997)
Published in Journal of cell science (01.01.1997)
Get full text
Journal Article
Abstract 1559: TLR7/8 immune-stimulating antibody conjugates elicit robust myeloid activation leading to enhanced effector function and anti-tumor immunity in pre-clinical models
Ackerman, Shelley E., Gonzalez, Joseph C., Gregorio, Josh D., Paik, Jason C., Hartmann, Felix J., Kenkel, Justin A., Lee, Arthur, Luo, Angela, Pearson, Cecelia I., Nguyen, Murray L., Ackerman, Benjamin, Sheu, Lauren Y., Laura, Richard P., Chapin, Steven J., Safina, Brian S., Bendall, Sean C., Dornan, David, Engleman, Edgar G., Alonso, Michael N.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 2730: Beyond antibodies and CAR-T: Topologically-engineered, super-dimeric antibody-like molecules with dual Fc domains for trispecific, bivalent targeting of CD19, CD20, and Fcgamma receptors
Capon, Daniel J., Chan, Nelson L., Troitskaya, Larisa, Fomin, Marina, Edman, Ursula, Frank, Brendon, Capon, Benjamin Z., Law, Brian, Chapin, Steven J., Lewis, Gavin M., Gefter, Malcolm L., Punnonen, Juha
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article