Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor
Macherla, Venkat R, Mitchell, Scott S, Manam, Rama Rao, Reed, Katherine A, Chao, Ta-Hsiang, Nicholson, Benjamin, Deyanat-Yazdi, Gordafaried, Mai, Bao, Jensen, Paul R, Fenical, William F, Neuteboom, Saskia T. C, Lam, Kin S, Palladino, Michael A, Potts, Barbara C. M
Published in Journal of medicinal chemistry (02.06.2005)
Published in Journal of medicinal chemistry (02.06.2005)
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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
Manam, Rama Rao, McArthur, Katherine A, Chao, Ta-Hsiang, Weiss, Jeffrey, Ali, Janid A, Palombella, Vito J, Groll, Michael, Lloyd, G. Kenneth, Palladino, Michael A, Neuteboom, Saskia T. C, Macherla, Venkat R, Potts, Barbara C. M
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Journal Article
Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes
Traves, Paqui G, Hortelano, Sonsoles, Zeini, Miriam, Chao, Ta-Hsiang, Lam, Thanh, Neuteboom, Saskia T, Theodorakis, Emmanuel A, Palladino, Michael A, Castrillo, Antonio, Bosca, Lisardo
Published in Molecular pharmacology (01.06.2007)
Published in Molecular pharmacology (01.06.2007)
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Journal Article
An Autologous Oral DNA Vaccine Protects against Murine Melanoma
Xiang, Rong, Lode, Holger N., Chao, Ta-Hsiang, Ruehlmann, J. Michael, Dolman, Carrie S., Rodriguez, Fernando, Whitton, J. Lindsay, Overwijk, Willem W., Restifo, Nicholas P., Reisfeld, Ralph A.
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2000)
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Journal Article
BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase
Hayashi, Masaaki, Tapping, Richard I., Chao, Ta-Hsiang, Lo, Jeng-Fan, King, Charles C., Yang, Young, Lee, Jiing-Dwan
Published in The Journal of biological chemistry (23.03.2001)
Published in The Journal of biological chemistry (23.03.2001)
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Journal Article
NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model
CUSACK, James C, RONG LIU, LIJUN XIA, CHAO, Ta-Hsiang, PIEN, Christine, WEI NIU, PALOMBELLA, Vito J, NEUTEBOOM, Saskia T. C, PALLADINO, Michael A
Published in Clinical cancer research (15.11.2006)
Published in Clinical cancer research (15.11.2006)
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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.
Published in Cancer cell (01.11.2005)
Published in Cancer cell (01.11.2005)
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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products
Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Chaturvedi, Madan M., Palladino, Michael A., Younes, Anas, Aggarwal, Bharat B.
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function
Chao, T H, Ember, J A, Wang, M, Bayon, Y, Hugli, T E, Ye, R D
Published in The Journal of biological chemistry (02.04.1999)
Published in The Journal of biological chemistry (02.04.1999)
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New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IκBα Phosphorylation
Chao, Ta-Hsiang, Lam, Thanh, Vong, Binh G, Través, Paqui G, Hortelano, Sonsoles, Chowdhury, Chinmay, Bahjat, F. Rena, Lloyd, G. Kenneth, Moldawer, Lyle L, Boscá, Lisardo, Palladino, Michael A, Theodorakis, Emmanuel A
Published in Chembiochem : a European journal of chemical biology (07.01.2005)
Published in Chembiochem : a European journal of chemical biology (07.01.2005)
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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs
Obaidat, Amanda, Weiss, Jeffrey, Wahlgren, Brett, Manam, Rama R, Macherla, Venkat R, McArthur, Katherine, Chao, Ta-Hsiang, Palladino, Michael A, Lloyd, G Kenneth, Potts, Barbara C, Enna, Salvatore J, Neuteboom, Saskia T C, Hagenbuch, Bruno
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
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Journal Article
Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome
Reed, Katherine A, Manam, Rama Rao, Mitchell, Scott S, Xu, Jianlin, Teisan, Sy, Chao, Ta-Hsiang, Deyanat-Yazdi, Gordafaried, Neuteboom, Saskia T. C, Lam, Kin S, Potts, Barbara C. M
Published in Journal of natural products (Washington, D.C.) (01.02.2007)
Published in Journal of natural products (Washington, D.C.) (01.02.2007)
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Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells
KIM, Sung-Woo, CHAO, Ta-Hsiang, RONG XIANG, LO, Jeng-Fan, CAMPBELL, Michael J, FEARNS, Colleen, LEE, Jiing-Dwan
Published in Cancer research (Chicago, Ill.) (01.11.2004)
Published in Cancer research (Chicago, Ill.) (01.11.2004)
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Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents
Lam, Thanh, Ling, Taotao, Chowdhury, Chinmay, Chao, Ta-Hsiang, Bahjat, F.R., Lloyd, G.K., Moldawer, Lyle L., Palladino, Michael A., Theodorakis, Emmanuel A.
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
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Journal Article
Synthesis of a Novel Family of Diterpenes and Their Evaluation as Antiinflammatory Agents
Lam, Thanh, Ling, Taotao, Chowdhury, Chinmay, Chao, Ta-Hsiang, Bahjat, F. R., Lloyd, G. K., Moldawer, Lyle L., Palladino, Michael A., Theodorakis, Emmanuel A.
Published in ChemInform (23.12.2003)
Published in ChemInform (23.12.2003)
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