Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
Green, Simon R., Davis, Susan H., Damerow, Sebastian, Engelhart, Curtis A., Mathieson, Michael, Baragaña, Beatriz, Robinson, David A., Tamjar, Jevgenia, Dawson, Alice, Tamaki, Fabio K., Buchanan, Kirsteen I., Post, John, Dowers, Karen, Shepherd, Sharon M., Jansen, Chimed, Zuccotto, Fabio, Gilbert, Ian H., Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Osuna-Cabello, Maria, Pérez-Herrán, Esther, Rebollo, María José, Guijarro López, Laura, Casado Castro, Patricia, Camino, Isabel, Kim, Heather C., Bean, James M., Nahiyaan, Navid, Rhee, Kyu Y., Wang, Qinglan, Tan, Vee Y., Boshoff, Helena I. M., Converse, Paul J., Li, Si-Yang, Chang, Yong S., Fotouhi, Nader, Upton, Anna M., Nuermberger, Eric L., Schnappinger, Dirk, Read, Kevin D., Encinas, Lourdes, Bates, Robert H., Wyatt, Paul G., Cleghorn, Laura A. T.
Published in Nature communications (11.10.2022)
Published in Nature communications (11.10.2022)
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Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
CHANG, Yong S, ADNANE, Jalila, WILKIE, Dean, CARTER, Christopher A, TAYLOR, Ian C. A, LYNCH, Mark, WILHELM, Scott, TRAIL, Pamela A, LEVY, Joan, HENDERSON, Arris, DAHAI XUE, BORTOLON, Elizabeth, ICHETOVKIN, Marina, CHEN, Charles, MCNABOLA, Angela
Published in Cancer chemotherapy and pharmacology (01.04.2007)
Published in Cancer chemotherapy and pharmacology (01.04.2007)
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth
JIN GAO, CHESEBROUGH, Jon W, COATS, Steven, BOSSLET, Klaus, CHANG, Yong S, CARTLIDGE, Susan A, RICKETTS, Sally-Ann, INCOGNITO, Leonard, VELDMAN-JONES, Margaret, BLAKEY, David C, TABRIZI, Mohammad, JALLAL, Bahija, TRAIL, Pamela A
Published in Cancer research (Chicago, Ill.) (01.02.2011)
Published in Cancer research (Chicago, Ill.) (01.02.2011)
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Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas
Ordonez, Alvaro A, Pokkali, Supriya, Kim, Sunhwa, Carr, Brian, Klunk, Mariah H, Tong, Leah, Saini, Vikram, Chang, Yong S, McKevitt, Matthew, Smith, Victoria, Gossage, David L, Jain, Sanjay K
Published in PloS one (14.05.2018)
Published in PloS one (14.05.2018)
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The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography
Zhang, Zhuo, Ordonez, Alvaro A, Smith-Jones, Peter, Wang, Hui, Gogarty, Kayla R, Daryaee, Fereidoon, Bambarger, Lauren E, Chang, Yong S, Jain, Sanjay K, Tonge, Peter J
Published in PloS one (02.02.2017)
Published in PloS one (02.02.2017)
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Mosaic Blood Vessels in Tumors: Frequency of Cancer Cells in Contact with Flowing Blood
Chang, Y S, di Tomaso, E, McDonald, D M, Jones, R, Jain, R K, Munn, L L
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development
Guerlavais, Vincent, Sawyer, Tomi K., Carvajal, Luis, Chang, Yong S., Graves, Bradford, Ren, Jian-Guo, Sutton, David, Olson, Karen A., Packman, Kathryn, Darlak, Krzysztof, Elkin, Carl, Feyfant, Eric, Kesavan, Kamala, Gangurde, Pranoti, Vassilev, Lyubomir T., Nash, Huw M., Vukovic, Vojislav, Aivado, Manuel, Annis, D. Allen
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Preserved Efficacy and Reduced Toxicity with Intermittent Linezolid Dosing in Combination with Bedaquiline and Pretomanid in a Murine Tuberculosis Model
Bigelow, Kristina M, Tasneen, Rokeya, Chang, Yong S, Dooley, Kelly E, Nuermberger, Eric L
Published in Antimicrobial agents and chemotherapy (21.09.2020)
Published in Antimicrobial agents and chemotherapy (21.09.2020)
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Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy
Chang, Yong S, Li, Si-Yang, Pertinez, Henry, Betoudji, Fabrice, Lee, Jin, Rannard, Steven P, Owen, Andrew, Nuermberger, Eric L, Ammerman, Nicole C
Published in Antimicrobial agents and chemotherapy (18.07.2023)
Published in Antimicrobial agents and chemotherapy (18.07.2023)
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A Systematic Approach for Developing Bacteria-Specific Imaging Tracers
Ordonez, Alvaro A, Weinstein, Edward A, Bambarger, Lauren E, Saini, Vikram, Chang, Yong S, DeMarco, Vincent P, Klunk, Mariah H, Urbanowski, Michael E, Moulton, Kimberly L, Murawski, Allison M, Pokkali, Supriya, Kalinda, Alvin S, Jain, Sanjay K
Published in Journal of Nuclear Medicine (01.01.2017)
Published in Journal of Nuclear Medicine (01.01.2017)
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Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo
Ashbaugh, Alyssa G., Jiang, Xuesong, Zheng, Jesse, Tsai, Andrew S., Kim, Woo-Shin, Thompson, John M., Miller, Robert J., Shahbazian, Jonathan H., Wang, Yu, Dillen, Carly A., Ordonez, Alvaro A., Chang, Yong S., Jain, Sanjay K., Jones, Lynne C., Sterling, Robert S., Mao, Hai-Quan, Miller, Lloyd S.
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
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A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors
Zhong, Haihong, Davis, April, Ouzounova, Maria, Carrasco, Rosa A, Chen, Cui, Breen, Shannon, Chang, Yong S, Huang, Jiaqi, Liu, Zheng, Yao, Yihong, Hurt, Elaine, Moisan, Jacques, Fung, Michael, Tice, David A, Clouthier, Shawn G, Xiao, Zhan, Wicha, Max S, Korkaya, Hasan, Hollingsworth, Robert E
Published in Cancer research (Chicago, Ill.) (15.01.2016)
Published in Cancer research (Chicago, Ill.) (15.01.2016)
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Incidental Carcinoid Tumor Arising in a Meckel's Diverticulum
Duran, Jonah R, White, Levi J, Dunn, Peter M, Chang, Yong S, Knauer, Andrew J
Published in Curēus (Palo Alto, CA) (03.09.2024)
Published in Curēus (Palo Alto, CA) (03.09.2024)
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Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9
Petrul, Heike M, Schatz, Christoph A, Kopitz, Charlotte C, Adnane, Lila, McCabe, Timothy J, Trail, Pamela, Ha, Sha, Chang, Yong S, Voznesensky, Andrei, Ranges, Gerald, Tamburini, Paul P
Published in Molecular cancer therapeutics (01.02.2012)
Published in Molecular cancer therapeutics (01.02.2012)
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Noninvasive 11 C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis
Tucker, Elizabeth W, Guglieri-Lopez, Beatriz, Ordonez, Alvaro A, Ritchie, Brittaney, Klunk, Mariah H, Sharma, Richa, Chang, Yong S, Sanchez-Bautista, Julian, Frey, Sarah, Lodge, Martin A, Rowe, Steven P, Holt, Daniel P, Gobburu, Jogarao V S, Peloquin, Charles A, Mathews, William B, Dannals, Robert F, Pardo, Carlos A, Kannan, Sujatha, Ivaturi, Vijay D, Jain, Sanjay K
Published in Science translational medicine (05.12.2018)
Published in Science translational medicine (05.12.2018)
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Shear-Induced Increase in Hydraulic Conductivity in Endothelial Cells Is Mediated by a Nitric Oxide–Dependent Mechanism
Chang, Yong S, Yaccino, Jean Ann, Lakshminarayanan, Sunitha, Frangos, John A, Tarbell, John M
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2000)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2000)
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Physiological transport properties of cultured retinal microvascular endothelial cell monolayers
Yaccino, J A, Chang, Y S, Hollis, T M, Gardner, T W, Tarbell, J M
Published in Current eye research (01.08.1997)
Published in Current eye research (01.08.1997)
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