MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate
Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque
Uslaner, Jason M., Eddins, Donnie, Puri, Vanita, Cannon, Christopher E., Sutcliffe, Jane, Chew, Chan Sing, Pearson, Michelle, Vivian, Jeffrey A., Chang, Ronald K., Ray, William J., Kuduk, Scott D., Wittmann, Marion
Published in Psychopharmacology (2013)
Published in Psychopharmacology (2013)
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Journal Article
MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate
Beshore, Douglas C, N Di Marco, Christina, Chang, Ronald K, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Fuerst, Joy, Hartman, George D, Bilodeau, Mark T, Ray, William J, Kuduk, Scott D
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold
Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Pitts, Daniel R, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T, Ray, William J
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Journal Article
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Greshock, Thomas J., Sanders, John M., Drolet, Robert E., Rajapakse, Hemaka A., Chang, Ronald K., Kim, Boyoung, Rada, Vanessa L., Tiscia, Heather E., Su, Hua, Lai, Ming-Tain, Sur, Sylvie M., Sanchez, Rosa I., Bilodeau, Mark T., Renger, John J., Kern, Jonathan T., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Journal Article
Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M1 Allosteric Muscarinic Receptor Modulators
Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Ray, William J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T
Published in ACS medicinal chemistry letters (09.09.2010)
Published in ACS medicinal chemistry letters (09.09.2010)
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Journal Article
Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series
Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Bilodeau, Mark T., Hartman, George D., Bock, Mark G.
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Journal Article
Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M1 Positive Allosteric Modulators
Kuduk, Scott D, Chang, Ronald K, Greshock, Thomas J, Ray, William J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
Preparation of 4-heteroaryl-4-cyanopiperidines via SNAr substitution reactions
Chang, Ronald K., Di Marco, Christina N., Pitts, Daniel R., Greshock, Thomas J., Kuduk, Scott D.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Journal Article
Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators
KUDUK, Scott D, DI MARCO, Christina N, BILODEAU, Mark T, CHANG, Ronald K, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew A, KOEPLINGER, Kenneth A, THOMPSON, Charles D, HARTMAN, George D
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Journal Article
Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Journal Article
Bradykinin B1 receptor antagonists : An α-hydroxy amide with an improved metabolism profile
KUDUK, Scott D, CHANG, Ronald K, BOCK, Mark G, DIPARDO, Robert M, DI MARCO, Christina N, MURPHY, Kathy L, RANSOM, Richard W, REISS, Duane R, TANG, Cuyue, PRUEKSARITANONT, Thomayant, PETTIBONE, Douglas J
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
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Journal Article
Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists
Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wai, Jenny M. C., DiPardo, Robert M., Murphy, Kathy L., Ransom, Richard W., Harrell, C. Meacham, Reiss, Duane R., Holahan, Marie A., Cook, Jacquelynn, Hess, J. Fred, Sain, Nova, Urban, Mark O., Tang, Cuyue, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
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Journal Article
Bradykinin B1 antagonists : Biphenyl SAR studies in the cyclopropanecarboxamide series
KUDUK, Scott D, DIPARDO, Robert M, BOCK, Mark G, CHANG, Ronald K, DI MARCO, Christina N, MURPHY, Kathy L, RANSOM, Richard W, REISS, Duane R, TANG, Cuyue, PRUEKSARITANONT, Thomayant, PETTIBONE, Douglas J
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D., Chang, Ronald K., Wai, Jenny M.-C., Di Marco, Christina N., Cofre, Victoria, DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity
FENG, Dong-Mei, DIPARDO, Robert M, PETTIBONE, Douglas J, BOCK, Mark G, KUDUK, Scott D, WAI, Jenny M, CHANG, Ronald K, DI MARCO, Christina N, MURPHY, Kathy L, RANSOM, Richard W, REISS, Duane R, CUYUE TANG, PRUEKSARITANONT, Thomayant
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists
WOOD, Michael R, SCHIRRIPA, Kathy M, CHANG, Raymond S. L, HOLAHAN, Marie A, COOK, Jacquelynn J, LEMAIRE, Wei, MOSSER, Scott D, BEDNAR, Rodney A, CUYUE TANG, PRUEKSARITANONT, Thomayant, WALLACE, Audrey A, QIN MEI, KIM, June J, JIAN YU, BOHN, Dennis L, CLAYTON, Frank C, ADARAYN, Emily D, SITKO, Gary R, LEONARD, Yvonne M, FREIDINGER, Roger M, PETTIBONE, Douglas J, BOCK, Mark G, KUDUK, Scott D, CHANG, Ronald K, DI MARCO, Christina N, DIPARDO, Robert M, WAN, Bang-Lin, MURPHY, Kathy L, RANSOM, Richard W
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists
Kuduk, Scott D., Di Marco, Christina Ng, Chang, Ronald K., Wood, Michael R., Kim, June J., Schirripa, Kathy M., Murphy, Kathy L., Ransom, Richard W., Tang, Cuyue, Torrent, Maricel, Ha, Sookhee, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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