In utero CRISPR-mediated therapeutic editing of metabolic genes
Rossidis, Avery C., Stratigis, John D., Chadwick, Alexandra C., Hartman, Heather A., Ahn, Nicholas J., Li, Haiying, Singh, Kshitiz, Coons, Barbara E., Li, Li, Lv, Wenjian, Zoltick, Philip W., Alapati, Deepthi, Zacharias, William, Jain, Rajan, Morrisey, Edward E., Musunuru, Kiran, Peranteau, William H.
Published in Nature medicine (01.10.2018)
Published in Nature medicine (01.10.2018)
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Journal Article
Acrolein impairs the cholesterol transport functions of high density lipoproteins
Chadwick, Alexandra C, Holme, Rebecca L, Chen, Yiliang, Thomas, Michael J, Sorci-Thomas, Mary G, Silverstein, Roy L, Pritchard, Jr, Kirkwood A, Sahoo, Daisy
Published in PloS one (07.04.2015)
Published in PloS one (07.04.2015)
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Journal Article
Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3
Chadwick, Alexandra C, Evitt, Niklaus H, Lv, Wenjian, Musunuru, Kiran
Published in Circulation (New York, N.Y.) (27.02.2018)
Published in Circulation (New York, N.Y.) (27.02.2018)
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Journal Article
CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia
Chadwick, Alexandra C, Musunuru, Kiran
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2018)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2018)
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Journal Article
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Journal Article
Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells
Kropp, Erin M., Oleson, Bryndon J., Broniowska, Katarzyna A., Bhattacharya, Subarna, Chadwick, Alexandra C., Diers, Anne R., Hu, Qinghui, Sahoo, Daisy, Hogg, Neil, Boheler, Kenneth R., Corbett, John A., Gundry, Rebekah L.
Published in Stem cells translational medicine (01.05.2015)
Published in Stem cells translational medicine (01.05.2015)
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Journal Article
In utero gene editing for monogenic lung disease
Alapati, Deepthi, Zacharias, William J, Hartman, Heather A, Rossidis, Avery C, Stratigis, John D, Ahn, Nicholas J, Coons, Barbara, Zhou, Su, Li, Hiaying, Singh, Kshitiz, Katzen, Jeremy, Tomer, Yaniv, Chadwick, Alexandra C, Musunuru, Kiran, Beers, Michael F, Morrisey, Edward E, Peranteau, William H
Published in Science translational medicine (17.04.2019)
Published in Science translational medicine (17.04.2019)
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Journal Article
Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis
Chen, Yiliang, Kennedy, David J, Ramakrishnan, Devi Prasadh, Yang, Moua, Huang, Wenxin, Li, Zhichuan, Xie, Zijian, Chadwick, Alexandra C, Sahoo, Daisy, Silverstein, Roy L
Published in Science signaling (08.09.2015)
Published in Science signaling (08.09.2015)
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Journal Article
Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress
Korytowski, Witold, Wawak, Katarzyna, Pabisz, Pawel, Schmitt, Jared C, Chadwick, Alexandra C, Sahoo, Daisy, Girotti, Albert W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2015)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2015)
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Journal Article
CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity
Beres, Amy J, Haribhai, Dipica, Chadwick, Alexandra C, Gonyo, Patrick J, Williams, Calvin B, Drobyski, William R
Published in The Journal of immunology (1950) (01.07.2012)
Published in The Journal of immunology (1950) (01.07.2012)
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Journal Article
NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif
Chadwick, Alexandra C., Jensen, Davin R., Hanson, Paul J., Lange, Philip T., Proudfoot, Sarah C., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy
Published in Structure (London) (07.03.2017)
Published in Structure (London) (07.03.2017)
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Journal Article
Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis
Chadwick, Alexandra C., Jensen, Davin R., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy
Published in Protein expression and purification (01.03.2015)
Published in Protein expression and purification (01.03.2015)
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Journal Article
Abstract 55: Disruption of PCSK9 Using a Targeted Base Editing Strategy
Chadwick, Alexandra C, Musunuru, Kiran
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2017)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2017)
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Journal Article