Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity
Fonfria, Elena, Elliott, Mark, Beard, Matthew, Chaddock, John A, Krupp, Johannes
Published in Toxins (04.07.2018)
Published in Toxins (04.07.2018)
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Engineered botulinum neurotoxins as new therapeutics
Masuyer, Geoffrey, Chaddock, John A, Foster, Keith A, Acharya, K Ravi
Published in Annual review of pharmacology and toxicology (01.01.2014)
Published in Annual review of pharmacology and toxicology (01.01.2014)
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Journal Article
Botulinum and tetanus neurotoxins: structure, function and therapeutic utility
Turton, Kathryn, Chaddock, John A, Acharya, K.Ravi
Published in Trends in Biochemical Sciences (01.11.2002)
Published in Trends in Biochemical Sciences (01.11.2002)
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Book Review
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Targeted secretion inhibitors-innovative protein therapeutics
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Journal Article
Book Review
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B
Masuyer, Geoffrey, Beard, Matthew, Cadd, Verity A., Chaddock, John A., Acharya, K. Ravi
Published in Journal of structural biology (01.04.2011)
Published in Journal of structural biology (01.04.2011)
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Journal Article
Engineering botulinum neurotoxin domains for activation by toxin light chain
Stancombe, Patrick R., Masuyer, Geoffrey, Birch‐Machin, Ian, Beard, Matthew, Foster, Keith A., Chaddock, John A., Acharya, K. Ravi
Published in The FEBS journal (01.02.2012)
Published in The FEBS journal (01.02.2012)
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Journal Article
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A
Masuyer, Geoffrey, Thiyagarajan, Nethaji, James, Peter L., Marks, Philip M.H., Chaddock, John A., Acharya, K. Ravi
Published in Biochemical and biophysical research communications (27.03.2009)
Published in Biochemical and biophysical research communications (27.03.2009)
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Journal Article
Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin
Duggan, Michael J, Quinn, Conrad P, Chaddock, John A, Purkiss, John R, Alexander, Frances C G, Doward, Sarah, Fooks, Sarah J, Friis, Lorna M, Hall, Yper H J, Kirby, Elizabeth R, Leeds, Nicola, Moulsdale, Hilary J, Dickenson, Anthony, Green, G Mark, Rahman, Wahida, Suzuki, Rie, Shone, Clifford C, Foster, Keith A
Published in The Journal of biological chemistry (20.09.2002)
Published in The Journal of biological chemistry (20.09.2002)
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Journal Article
Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain
Chaddock, John A., Purkiss, John R., Alexander, Frances C.G., Doward, Sarah, Fooks, Sarah J., Friis, Lorna M., Hall, Yper H.J., Kirby, Elizabeth R., Leeds, Nicola, Moulsdale, Hilary J., Dickenson, Anthony, Green, G. Mark, Rahman, Wahida, Suzuki, Rie, Duggan, Michael J., Quinn, Conrad P., Shone, Clifford C., Foster, Keith A.
Published in Movement disorders (01.03.2004)
Published in Movement disorders (01.03.2004)
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Conference Proceeding
Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating
He, Yan, Elias, Chadwick L, Huang, Ya-Chi, Gao, Xiaodong, Leung, Yuk-Man, Kang, Youhou, Xie, Huanli, Chaddock, John A, Tsushima, Robert G, Gaisano, Herbert Y
Published in Pancreas (01.01.2008)
Published in Pancreas (01.01.2008)
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Journal Article
Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A
Chaddock, John A., Herbert, Michael H., Ling, Roger J., Alexander, Frances C.G., Fooks, Sarah J., Revell, Dean F., Quinn, Conrad P., Shone, Clifford C., Foster, Keith A.
Published in Protein expression and purification (01.07.2002)
Published in Protein expression and purification (01.07.2002)
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Journal Article
Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies
Hall, Yper H.J, Chaddock, John A, Moulsdale, Hilary J, Kirby, Elizabeth R, Alexander, Frances C.G, Marks, James D, Foster, Keith A
Published in Journal of immunological methods (01.05.2004)
Published in Journal of immunological methods (01.05.2004)
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Journal Article
Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications
Sutton, J. Mark, Wayne, Jonathan, Scott-Tucker, Anthony, O’Brien, Susan M., Marks, Philip M.H., Alexander, Frances C.G., Shone, Clifford C., Chaddock, John A.
Published in Protein expression and purification (01.03.2005)
Published in Protein expression and purification (01.03.2005)
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Journal Article
Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin
Stancombe, Patrick R, Alexander, Frances C.G, Ling, Roger, Matheson, Mary A, Shone, Clifford C, Chaddock, John A
Published in Protein expression and purification (01.08.2003)
Published in Protein expression and purification (01.08.2003)
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Journal Article
Phage-assisted continuous evolution of botulinum neurotoxin light chains generates novel light chains with modified snare cleavage specificity
Foster, Keith, Blum, Travis, Beard, Matthew, Chaddock, John, Kupinski, Adam, Harding, Adam, Packer, Michael, Liu, David
Published in Toxicon (Oxford) (01.12.2018)
Published in Toxicon (Oxford) (01.12.2018)
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