Enhancements and Limits in Drug Membrane Transport Using Supersaturated Solutions of Poorly Water Soluble Drugs
Raina, Shweta A., Zhang, Geoff G.Z., Alonzo, David E., Wu, Jianwei, Zhu, Donghua, Catron, Nathaniel D., Gao, Yi, Taylor, Lynne S.
Published in Journal of pharmaceutical sciences (01.09.2014)
Published in Journal of pharmaceutical sciences (01.09.2014)
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Impact of Solubilizing Additives on Supersaturation and Membrane Transport of Drugs
Raina, Shweta A., Zhang, Geoff G. Z., Alonzo, David E., Wu, Jianwei, Zhu, Donghua, Catron, Nathaniel D., Gao, Yi, Taylor, Lynne S.
Published in Pharmaceutical research (01.10.2015)
Published in Pharmaceutical research (01.10.2015)
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High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody–Drug Conjugate Aggregation and Drug Release
Durbin, Kenneth R, Nottoli, M. Shannon, Catron, Nathaniel D, Richwine, Nicole, Jenkins, Gary J
Published in ACS omega (31.08.2017)
Published in ACS omega (31.08.2017)
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W
Published in Nature medicine (01.02.2013)
Published in Nature medicine (01.02.2013)
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Pharmaceutical Development Challenges in a Beyond Rule of Five Prodrug: Case Study of ABBV-167, Phosphate Prodrug of Venetoclax
Hong, Richard, Nie, Haichen, Henry, Rodger F., Garner, Sean M., Catron, Nathaniel D., Hertzler, Russell L., Souers, Andrew J., Sheikh, Ahmad Y., Chen, Shuang
Published in Molecular pharmaceutics (06.11.2023)
Published in Molecular pharmaceutics (06.11.2023)
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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199
Choo, Edna F, Boggs, Jason, Zhu, Chunqiang, Lubach, Joseph W, Catron, Nathaniel D, Jenkins, Gary, Souers, Andrew J, Voorman, Richard
Published in Drug metabolism and disposition (01.02.2014)
Published in Drug metabolism and disposition (01.02.2014)
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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers
Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F, Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W, Fournier, Keith M, Harper, Kaid C, Hong, Richard, Jenkins, Gary J, Ji, Jianguo, Judge, Russell A, Kalvass, John C, Klix, Russell C, Ku, Yi-Yin, Leverson, Joel D, Marks, Richard A, Marsh, Kennan C, Menon, Rajeev M, Park, Chang H, Phillips, Darren C, Pu, Yu-Ming, Rosenberg, Saul H, Sanzgiri, Yeshwant D, Sheikh, Ahmad Y, Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A, Wang, Xilu, Zhang, Geoff G Z, Catron, Nathaniel D, Souers, Andrew J
Published in Molecular cancer therapeutics (01.06.2021)
Published in Molecular cancer therapeutics (01.06.2021)
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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
TONG PING, SCHMITT ERIC A, LINDLEY DAVID J, MILLER JONATHAN, CATRON NATHANIEL D
Year of Publication 04.06.2018
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Year of Publication 04.06.2018
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APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, CATRON NATHANIEL D
Year of Publication 17.07.2017
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Year of Publication 17.07.2017
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SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
TONG PING, SCHMITT ERIC A, LINDLEY DAVID J, MILLER JONATHAN, CATRON NATHANIEL D
Year of Publication 09.05.2014
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Year of Publication 09.05.2014
Patent
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X-L Inhibitor
Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, CATRON NATHANIEL D
Year of Publication 05.08.2013
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Year of Publication 05.08.2013
Patent
ABT-263 CRYSTALLINE FORMS AND SOLVATES FOR USE IN TREATING BCL-2 PROTEIN RELATED DISEASES
BORCHARDT THOMAS B, ZHANG GEOFF G.Z, BRACKEMEYER PAUL J, CATRON NATHANIEL D
Year of Publication 01.08.2012
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Year of Publication 01.08.2012
Patent
Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M., Park, Chang H., Boghaert, Erwin R., Catron, Nathaniel D., Chen, Jun, Colman, Peter M., Czabotar, Peter E., Deshayes, Kurt, Fairbrother, Wayne J., Flygare, John A., Hymowitz, Sarah G., Jin, Sha, Judge, Russell A., Koehler, Michael F. T., Kovar, Peter J., Lessene, Guillaume, Mitten, Michael J., Ndubaku, Chudi O., Nimmer, Paul, Purkey, Hans E., Oleksijew, Anatol, Phillips, Darren C., Sleebs, Brad E., Smith, Brian J., Smith, Morey L., Tahir, Stephen K., Watson, Keith G., Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H., Tse, Chris, Leverson, Joel D., Elmore, Steven W., Souers, Andrew J.
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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