Global mRNA selection mechanisms for translation initiation
Costello, Joseph, Castelli, Lydia M, Rowe, William, Kershaw, Christopher J, Talavera, David, Mohammad-Qureshi, Sarah S, Sims, Paul F G, Grant, Christopher M, Pavitt, Graham D, Hubbard, Simon J, Ashe, Mark P
Published in Genome Biology (05.01.2015)
Published in Genome Biology (05.01.2015)
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Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura
Published in EBioMedicine (01.02.2019)
Published in EBioMedicine (01.02.2019)
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RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy
Burrows, David J, McGown, Alexander, Abduljabbar, Olfat, Castelli, Lydia M, Shaw, Pamela J, Hautbergue, Guillaume M, Ramesh, Tennore M
Published in Annals of neurology (31.08.2024)
Published in Annals of neurology (31.08.2024)
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Journal Article
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function
Mihaylov, Simeon R., Castelli, Lydia M., Lin, Ya-Hui, Gül, Aytac, Soni, Nikita, Hastings, Christopher, Flynn, Helen R., Păun, Oana, Dickman, Mark J., Snijders, Ambrosius P., Goldstone, Robert, Bandmann, Oliver, Shelkovnikova, Tatyana A., Mortiboys, Heather, Ultanir, Sila K., Hautbergue, Guillaume M.
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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Journal Article
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Allen, Scott P, Hall, Benjamin, Castelli, Lydia M, Francis, Laura, Woof, Ryan, Siskos, Alexandros P, Kouloura, Eirini, Gray, Elizabeth, Thompson, Alexander G, Talbot, Kevin, Higginbottom, Adrian, Myszczynska, Monika, Allen, Chloe F, Stopford, Matthew J, Hemingway, Jordan, Bauer, Claudia S, Webster, Christopher P, De Vos, Kurt J, Turner, Martin R, Keun, Hector C, Hautbergue, Guillaume M, Ferraiuolo, Laura, Shaw, Pamela J
Published in Brain (London, England : 1878) (01.03.2019)
Published in Brain (London, England : 1878) (01.03.2019)
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Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura
Published in Aging cell (01.01.2021)
Published in Aging cell (01.01.2021)
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Journal Article
Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress
Lui, Jennifer, Castelli, Lydia M., Pizzinga, Mariavittoria, Simpson, Clare E., Hoyle, Nathaniel P., Bailey, Kathryn L., Campbell, Susan G., Ashe, Mark P.
Published in Cell reports (Cambridge) (06.11.2014)
Published in Cell reports (Cambridge) (06.11.2014)
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Journal Article
Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control
Kershaw, Christopher J., Nelson, Michael G., Castelli, Lydia M., Jennings, Martin D., Lui, Jennifer, Talavera, David, Grant, Chris M., Pavitt, Graham D., Hubbard, Simon J., Ashe, Mark P.
Published in The Journal of biological chemistry (01.10.2023)
Published in The Journal of biological chemistry (01.10.2023)
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Journal Article
Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
Costello, Joseph L, Kershaw, Christopher J, Castelli, Lydia M, Talavera, David, Rowe, William, Sims, Paul F G, Ashe, Mark P, Grant, Christopher M, Hubbard, Simon J, Pavitt, Graham D
Published in Genome Biology (27.10.2017)
Published in Genome Biology (27.10.2017)
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Journal Article
The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response
Kershaw, Christopher J, Costello, Joseph L, Castelli, Lydia M, Talavera, David, Rowe, William, Sims, Paul F G, Ashe, Mark P, Hubbard, Simon J, Pavitt, Graham D, Grant, Chris M
Published in PLoS genetics (01.01.2015)
Published in PLoS genetics (01.01.2015)
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Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes
Nwokoye, Ebelechukwu C., AlNaseem, Eiman, Crawford, Robert A., Castelli, Lydia M., Jennings, Martin D., Kershaw, Christopher J., Pavitt, Graham D.
Published in Scientific reports (29.06.2021)
Published in Scientific reports (29.06.2021)
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Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
Shaw, Matthew P, Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M, James, Evlyn, Hautbergue, Guillaume M, Shaw, Pamela J, Ramesh, Tennore M
Published in Acta neuropathologica communications (19.11.2018)
Published in Acta neuropathologica communications (19.11.2018)
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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations
Allen, Scott P, Al Sultan, Afnan, Kabucho Kibirige, Elaine, Tonkiss, Erin, Hamer, Keaton J, Castelli, Lydia M, Lin, Ya-Hui, Roscoe, Sarah, Stefanidis, Nikolaos, Mead, Richard J, Highley, J Robin, Cooper-Knock, Johnathan, Hautbergue, Guillaume M, Heath, Paul R, Kirby, Janine, Shaw, Pamela J
Published in Frontiers in aging neuroscience (11.05.2023)
Published in Frontiers in aging neuroscience (11.05.2023)
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Journal Article
The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation
Castelli, Lydia M, Talavera, David, Kershaw, Christopher J, Mohammad-Qureshi, Sarah S, Costello, Joseph L, Rowe, William, Sims, Paul F G, Grant, Christopher M, Hubbard, Simon J, Ashe, Mark P, Pavitt, Graham D
Published in PLoS genetics (01.05.2015)
Published in PLoS genetics (01.05.2015)
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Journal Article
A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins
Castelli, Lydia M, Lin, Ya-Hui, Sanchez-Martinez, Alvaro, Gül, Aytaç, Mohd Imran, Kamallia, Higginbottom, Adrian, Upadhyay, Santosh Kumar, Márkus, Nóra M, Rua Martins, Raquel, Cooper-Knock, Johnathan, Montmasson, Claire, Cohen, Rebecca, Walton, Amy, Bauer, Claudia S, De Vos, Kurt J, Mead, Richard J, Azzouz, Mimoun, Dominguez, Cyril, Ferraiuolo, Laura, Shaw, Pamela J, Whitworth, Alexander J, Hautbergue, Guillaume M
Published in Science translational medicine (01.03.2023)
Published in Science translational medicine (01.03.2023)
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Journal Article
RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration
Castelli, Lydia M, Benson, Bridget C, Huang, Wan-Ping, Lin, Ya-Hui, Hautbergue, Guillaume M
Published in Frontiers in genetics (12.05.2022)
Published in Frontiers in genetics (12.05.2022)
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Journal Article
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Castelli, Lydia M, Cutillo, Luisa, Souza, Cleide Dos Santos, Sanchez-Martinez, Alvaro, Granata, Ilaria, Lin, Ya-Hui, Myszczynska, Monika A, Heath, Paul R, Livesey, Matthew R, Ning, Ke, Azzouz, Mimoun, Shaw, Pamela J, Guarracino, Mario R, Whitworth, Alexander J, Ferraiuolo, Laura, Milo, Marta, Hautbergue, Guillaume M
Published in Molecular neurodegeneration (10.08.2021)
Published in Molecular neurodegeneration (10.08.2021)
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Journal Article
Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated
Castelli, Lydia M, Lui, Jennifer, Campbell, Susan G, Rowe, William, Zeef, Leo A H, Holmes, Leah E A, Hoyle, Nathaniel P, Bone, Jonathon, Selley, Julian N, Sims, Paul F G, Ashe, Mark P
Published in Molecular biology of the cell (15.09.2011)
Published in Molecular biology of the cell (15.09.2011)
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Journal Article
Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies
Hoyle, Nathaniel P, Castelli, Lydia M, Campbell, Susan G, Holmes, Leah E.A, Ashe, Mark P
Published in The Journal of cell biology (08.10.2007)
Published in The Journal of cell biology (08.10.2007)
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