I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice
Mota, Bibiana C, Ashburner, Nathan, Abelleira-Hervas, Laura, Liu, Liyueyue, Aleksynas, Robertas, Rovati, Lucio Claudio, Caselli, Gianfranco, Sastre, Magdalena
Published in International journal of molecular sciences (30.06.2022)
Published in International journal of molecular sciences (30.06.2022)
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Journal Article
Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug
Caselli, Gianfranco, Bonazzi, Albino, Lanza, Marco, Ferrari, Flora, Maggioni, Daniele, Ferioli, Cristian, Giambelli, Roberto, Comi, Eleonora, Zerbi, Silvia, Perrella, Marco, Letari, Ornella, Di Luccio, Elena, Colovic, Milena, Persiani, Stefano, Zanelli, Tiziano, Mennuni, Laura, Piepoli, Tiziana, Rovati, Lucio Claudio
Published in Arthritis research & therapy (01.03.2018)
Published in Arthritis research & therapy (01.03.2018)
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Journal Article
Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties
Puja, Giulia, Losi, Gabriele, Rovati, Lucio, Lanza, Marco, Caselli, Gianfranco, Bardoni, Rita
Published in Frontiers in pain research (Lausanne, Switzerland) (22.09.2022)
Published in Frontiers in pain research (Lausanne, Switzerland) (22.09.2022)
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Journal Article
Ferulated Poly(vinyl alcohol) based hydrogels
Pepi, Simone, Paolino, Marco, Saletti, Mario, Venditti, Jacopo, Talarico, Luigi, Andreassi, Marco, Giuliani, Germano, Caselli, Gianfranco, Artusi, Roberto, Cappelli, Andrea, Leone, Gemma, Magnani, Agnese, Rovati, Lucio
Published in Heliyon (01.11.2023)
Published in Heliyon (01.11.2023)
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Journal Article
Development of Imidazole-Reactive Molecules Leading to a New Aggregation-Induced Emission Fluorophore Based on the Cinnamic Scaffold
Razzano, Vincenzo, Paolino, Marco, Reale, Annalisa, Giuliani, Germano, Artusi, Roberto, Caselli, Gianfranco, Visintin, Michela, Makovec, Francesco, Donati, Alessandro, Villafiorita-Monteleone, Francesca, Botta, Chiara, Cappelli, Andrea
Published in ACS omega (30.09.2017)
Published in ACS omega (30.09.2017)
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Journal Article
IL-18 cDNA Vaccination Protects Mice from Spontaneous Lupus-like Autoimmune Disease
Bossù, Paola, Neumann, Detlef, Del Giudice, Elda, Ciaramella, Antonio, Gloaguen, Isabelle, Fantuzzi, Giamila, Dinarello, Charles A., Di Carlo, Emma, Musiani, Piero, Meroni, Pier Luigi, Caselli, Gianfranco, Ruggiero, Paolo, Boraschi, Diana
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
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Journal Article
Experimental Pharmacology of Glucosamine Sulfate
Piepoli, Tiziana, Chiusaroli, Riccardo, Zanelli, Tiziano, Ballanti, Paola, Lanza, Marco, Rovati, Lucio C., Caselli, Gianfranco
Published in International Journal of Rheumatology (01.01.2011)
Published in International Journal of Rheumatology (01.01.2011)
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Journal Article
Induction of autophagic cell death by a novel molecule Is increased by hypoxia
Tafani, Marco, Schito, Luana, Anwar, Tahira, Indelicato, Manuela, Sale, Patrizio, Di Vito, Maura, Morgante, Emanuela, Beraldi, Rosanna, Makovec, Francesco, Letari, Ornella, Caselli, Gianfranco, Spadafora, Corrado, Pucci, Bruna, Russo, Matteo A.
Published in Autophagy (16.11.2008)
Published in Autophagy (16.11.2008)
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Journal Article
Modulation of human estrogen receptor α F promoter by a protein kinase C/c-Src-dependent mechanism in osteoblast-like cells
Longo, Maurizio, Peruzzi, Barbara, Fortunati, Dario, De Luca, Veronica, Denger, Stefanie, Caselli, Gianfranco, Migliaccio, Silvia, Teti, Anna
Published in Journal of molecular endocrinology (01.12.2006)
Published in Journal of molecular endocrinology (01.12.2006)
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Journal Article
LB-005 - CR10049, THE FIRST OA-TARGETED KINASE INHIBITOR, IMPROVES PAIN BEHAVIOUR, RESOLVES INFLAMMATION AND PRESERVES JOINT STRUCTURE IN SMALL AND LARGE ANIMAL MODELS
Piepoli, Tiziana, Giancotti, Luigino A., Artusi, Roberto, Ghirri, Matteo, Visintin, Michela, Caselli, Gianfranco, Rovati, Lucio
Published in Osteoarthritis and cartilage (01.06.2024)
Published in Osteoarthritis and cartilage (01.06.2024)
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Journal Article
CR10049, THE FIRST OA-TARGETED KINASE INHIBITOR, IMPROVES PAIN BEHAVIOUR, RESOLVES INFLAMMATION AND PRESERVES JOINT STRUCTURE IN SMALL AND LARGE ANIMAL MODELS
Piepoli, Tiziana, Giancotti, Luigino A., Artusi, Roberto, Ghirri, Matteo, Visintin, Michela, Caselli, Gianfranco, Rovati, Lucio
Published in Osteoarthritis and cartilage (01.06.2024)
Published in Osteoarthritis and cartilage (01.06.2024)
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Journal Article
CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons
Vellani, Vittorio, Sabatini, Chiara, Milia, Chiara, Caselli, Gianfranco, Lanza, Marco, Letari, Ornella, Rovati, Lucio Claudio, Giacomoni, Chiara
Published in British journal of pharmacology (01.01.2020)
Published in British journal of pharmacology (01.01.2020)
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Journal Article
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models
Conforti, Antonella, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Ravà, Micol, Fumagalli, Valeria, Muzi, Alessia, Maffei, Mariano, Luberto, Laura, Lione, Lucia, Salvatori, Erika, Compagnone, Mirco, Pinto, Eleonora, Pavoni, Emiliano, Bucci, Federica, Vitagliano, Grazia, Stoppoloni, Daniela, Pacello, Maria Lucrezia, Cappelletti, Manuela, Ferrara, Fabiana Fosca, D’Acunto, Emanuela, Chiarini, Valerio, Arriga, Roberto, Nyska, Abraham, Di Lucia, Pietro, Marotta, Davide, Bono, Elisa, Giustini, Leonardo, Sala, Eleonora, Perucchini, Chiara, Paterson, Jemma, Ryan, Kathryn Ann, Challis, Amy-Rose, Matusali, Giulia, Colavita, Francesca, Caselli, Gianfranco, Criscuolo, Elena, Clementi, Nicola, Mancini, Nicasio, Groß, Rüdiger, Seidel, Alina, Wettstein, Lukas, Münch, Jan, Donnici, Lorena, Conti, Matteo, De Francesco, Raffaele, Kuka, Mirela, Ciliberto, Gennaro, Castilletti, Concetta, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Guidotti, Luca G., Rovati, Lucio, Iannacone, Matteo, Aurisicchio, Luigi
Published in Molecular therapy (05.01.2022)
Published in Molecular therapy (05.01.2022)
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Journal Article
A first-in-human trial on the safety and immunogenicity of COVID-eVax, a cellular response-skewed DNA vaccine against COVID-19
Aurisicchio, Luigi, Brambilla, Nadia, Cazzaniga, Marina E., Bonfanti, Paolo, Milleri, Stefano, Ascierto, Paolo A., Capici, Serena, Vitalini, Cristina, Girolami, Federica, Giacovelli, Giampaolo, Caselli, Gianfranco, Visintin, Michela, Fanti, Francesca, Ghirri, Matteo, Conforti, Antonella, Compagnone, Mirco, Lione, Lucia, Salvatori, Erika, Pinto, Eleonora, Muzi, Alessia, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Manenti, Alessandro, Montomoli, Emanuele, Cadossi, Matteo, Rovati, Lucio C.
Published in Molecular therapy (01.03.2023)
Published in Molecular therapy (01.03.2023)
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Journal Article
Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models
Sala, Emanuele, Ferrari, Flora, Lanza, Marco, Milia, Chiara, Sabatini, Chiara, Bonazzi, Albino, Comi, Eleonora, Borsi Franchini, Miriam, Caselli, Gianfranco, Rovati, Lucio Claudio
Published in British journal of pharmacology (01.07.2020)
Published in British journal of pharmacology (01.07.2020)
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Journal Article
Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients
Porreca, Ettore, Sergi, Rita, Baccante, Giovanna, Reale, Marcella, Orsini, Luciano, Di Febbo, Concetta, Caselli, Gianfranco, Cuccurullo, Franco, Bertini, Riccardo
Published in Atherosclerosis (01.10.1999)
Published in Atherosclerosis (01.10.1999)
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Journal Article
Abstract 2208: Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in mice
Caselli, Gianfranco, Ferrari, Flora, Piepoli, Tiziana, Grotti, Adriana, Cavagnoli, Rosanna, Montagna, Giuseppe M., Romanelli, Pierpaolo, Bonazzi, Albino, Lanza, Marco, Recordati, Camilla, Rovati, Lucio C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4219: Efficacy of CR13626, a novel oral brain penetrant multi-kinase inhibitor, in a mouse model of glioblastoma
Galimberti, Chiara, Piepoli, Tiziana, Montagna, Giuseppe M., Zerbi, Silvia, Letari, Ornella, Artusi, Roberto, Colovic, Milena, Persiani, Stefano, Caselli, Gianfranco, Rovati, Lucio C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Pharmacological characterisation of CR6086, a potent prostaglandin E 2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug
Caselli, Gianfranco, Bonazzi, Albino, Lanza, Marco, Ferrari, Flora, Maggioni, Daniele, Ferioli, Cristian, Giambelli, Roberto, Comi, Eleonora, Zerbi, Silvia, Perrella, Marco, Letari, Ornella, Di Luccio, Elena, Colovic, Milena, Persiani, Stefano, Zanelli, Tiziano, Mennuni, Laura, Piepoli, Tiziana, Rovati, Lucio Claudio
Published in Arthritis research & therapy (01.03.2018)
Published in Arthritis research & therapy (01.03.2018)
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Journal Article