Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)
Mussari, Christopher P, Dodd, Dharmpal S, Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L, Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L, Salter-Cid, Luisa M, Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A, Carter, Percy H, Dyckman, Alaric J
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
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Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist
Hou, Xiaoping, Zhang, Huiping, Chen, Bang-Chi, Guo, Zhiwei, Singh, Amarjit, Goswami, Animesh, Gilmore, John L, Sheppeck, James E, Dyckman, Alaric J, Carter, Percy H, Mathur, Arvind
Published in Organic process research & development (17.02.2017)
Published in Organic process research & development (17.02.2017)
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An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist
Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H, Pitts, William J, Dyckman, Alaric J, Carter, Percy H, Mathur, Arvind, Zhang, Huiping
Published in Organic process research & development (20.05.2016)
Published in Organic process research & development (20.05.2016)
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Enantioselective Synthesis of Benzyl (1S,2R,4R)-4-(tert-Butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate Using an Iodolactamization As the Key Step
Campbell, Carlton L, Hassler, Carla, Ko, Soo S, Voss, Matthew E, Guaciaro, Michael A, Carter, Percy H, Cherney, Robert J
Published in Journal of organic chemistry (21.08.2009)
Published in Journal of organic chemistry (21.08.2009)
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Journal Article
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D’Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Journal Article
Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists
Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Nelson, David J, Lo, Yvonne C, Yang, Gengjie, Scherle, Peggy A, Mandlekar, Sandhya, Wasserman, Zelda R, Jezak, Heather, Solomon, Kimberly A, Tebben, Andrew J, Carter, Percy H, Decicco, Carl P
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2
Liu, Chunjian, Lin, James, Langevine, Charles, Smith, Daniel, Li, Jianqing, Tokarski, John S., Khan, Javed, Ruzanov, Max, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Gillooly, Kathleen M., Shuster, David, Zhang, Yifan, Thankappan, Anil, McIntyre, Kim W., Chaudhry, Charu, Elzinga, Paul A., Chiney, Manoj, Chimalakonda, Anjaneya, Lombardo, Louis J., Macor, John E., Carter, Percy H., Burke, James R., Weinstein, David S.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Identification of N‑Methyl Nicotinamide and N‑Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)
Moslin, Ryan, Zhang, Yanlei, Wrobleski, Stephen T, Lin, Shuqun, Mertzman, Michael, Spergel, Steven, Tokarski, John S, Strnad, Joann, Gillooly, Kathleen, McIntyre, Kim W, Zupa-Fernandez, Adriana, Cheng, Lihong, Sun, Huadong, Chaudhry, Charu, Huang, Christine, D’Arienzo, Celia, Heimrich, Elizabeth, Yang, Xiaoxia, Muckelbauer, Jodi K, Chang, ChiehYing, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Aranibar, Nelly, Chiney, Manoj, Burke, James R, Lombardo, Louis, Carter, Percy H, Weinstein, David S
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
Watterson, Scott H, Liu, Qingjie, Beaudoin Bertrand, Myra, Batt, Douglas G, Li, Ling, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Moore, Robin, Yang, Zheng, Vickery, Rodney, Elzinga, Paul A, Discenza, Lorell, D’Arienzo, Celia, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, Zhang, Yifan, Heimrich, Elizabeth, McIntyre, Kim W, Ruan, Qian, Westhouse, Richard A, Catlett, Ian M, Zheng, Naiyu, Chaudhry, Charu, Dai, Jun, Galella, Michael A, Tebben, Andrew J, Pokross, Matt, Li, Jianqing, Zhao, Rulin, Smith, Daniel, Rampulla, Richard, Allentoff, Alban, Wallace, Michael A, Mathur, Arvind, Salter-Cid, Luisa, Macor, John E, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A
Published in Journal of medicinal chemistry (11.04.2019)
Published in Journal of medicinal chemistry (11.04.2019)
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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)
Kempson, James, Zhao, Rulin, Pawluczyk, Joseph, Wang, Bei, Zhang, Huiping, Hou, Xiaoping, Allen, Martin P., Wu, Dauh-Rurng, Li, Peng, Yip, Shiuhang, Smith, Aaron, Traeger, Sarah C., Huang, Stella, Cutrone, Jingfang, Mukherjee, Subha, Sfouggatakis, Chris, Poss, Michael, Scola, Paul M., Meanwell, Nicholas A., Carter, Percy H., Mathur, Arvind
Published in Journal of organic chemistry (17.05.2024)
Published in Journal of organic chemistry (17.05.2024)
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Journal Article
Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J., Brogan, John B., Mo, Ruowei, Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Molino, Bruce F., Carter, Percy H., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Investigating investment in biopharmaceutical R&D
Carter, Percy H., Berndt, Ernst R., DiMasi, Joseph A., Trusheim, Mark
Published in Nature reviews. Drug discovery (01.10.2016)
Published in Nature reviews. Drug discovery (01.10.2016)
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Journal Article
Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J., Nelson, David J., Lo, Yvonne C., Yang, Gengjie, Scherle, Peggy A., Jezak, Heather, Solomon, Kimberly A., Carter, Percy H., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
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Discovery of 6‑Fluoro-5‑(R)‑(3‑(S)‑(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)‑yl)-2-methylphenyl)-2‑(S)‑(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro‑1H‑carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
Watterson, Scott H, De Lucca, George V, Shi, Qing, Langevine, Charles M, Liu, Qingjie, Batt, Douglas G, Beaudoin Bertrand, Myra, Gong, Hua, Dai, Jun, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Wang, Chunlei, Zhang, Yingru, Traeger, Sarah C, Pattoli, Mark A, Skala, Stacey, Cheng, Lihong, Obermeier, Mary T, Vickery, Rodney, Discenza, Lorell N, D’Arienzo, Celia J, Zhang, Yifan, Heimrich, Elizabeth, Gillooly, Kathleen M, Taylor, Tracy L, Pulicicchio, Claudine, McIntyre, Kim W, Galella, Michael A, Tebben, Andy J, Muckelbauer, Jodi K, Chang, ChiehYing, Rampulla, Richard, Mathur, Arvind, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Fura, Aberra, Burke, James R, Tino, Joseph A
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe
Carter, Percy H, Liu, Rui-Qin, Foster, William R, Tamasi, Joseph A, Tebben, Andrew J, Favata, Margaret, Staal, Ada, Cvijic, Mary Ellen, French, Michele H, Dell, Vanessa, Apanovitch, Donald, Lei, Ming, Zhao, Qihong, Cunningham, Mark, Decicco, Carl P, Trzaskos, James M, Feyen, Jean H.M
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2007)
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Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation
Das, Anuk M, Vaddi, Krishna G, Solomon, Kimberly A, Krauthauser, Candice, Jiang, Xiaosui, McIntyre, Kim W, Yang, Xiao Xia, Wadman, Eric, Welch, Patricia, Covington, Maryanne, Graden, Danielle, Yeleswaram, Krishnaswamy, Trzaskos, James M, Newton, Robert C, Mandlekar, Sandhya, Ko, Soo S, Carter, Percy H, Davies, Paul
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
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The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity
Seigal, Benjamin A, Connors, William H, Fraley, Andrew, Borzilleri, Robert M, Carter, Percy H, Emanuel, Stuart L, Fargnoli, Joseph, Kim, Kyoung, Lei, Ming, Naglich, Joseph G, Pokross, Matthew E, Posy, Shana L, Shen, Henry, Surti, Neha, Talbott, Randy, Zhang, Yong, Terrett, Nicholas K
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy
Marcoux, David, Duan, James J.-W, Shi, Qing, Cherney, Robert J, Srivastava, Anurag S, Cornelius, Lyndon, Batt, Douglas G, Liu, Qingjie, Beaudoin-Bertrand, Myra, Weigelt, Carolyn A, Khandelwal, Purnima, Vishwakrishnan, Sureshbabu, Selvakumar, Kumaravel, Karmakar, Ananta, Gupta, Arun Kumar, Basha, Mushkin, Ramlingam, Sridharan, Manjunath, Naveen, Vanteru, Sridhar, Karmakar, Sukhen, Maddala, Nageswara, Vetrichelvan, Muthalagu, Gupta, Anuradha, Rampulla, Richard A, Mathur, Arvind, Yip, Shiuhang, Li, Peng, Wu, Dauh-Rurng, Khan, Javed, Ruzanov, Max, Sack, John S, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Li, Sha, Shuster, David J, Borowski, Virna, Xie, Jenny H, McIntyre, Kim W, Obermeier, Mary T, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Hynes, John, Tino, Joseph A, Macor, John E, Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H, Dhar, T. G. Murali
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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