MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
LIVERTON, Nigel J, CARROLL, Steven S, OLSEN, David B, RUDD, Michael T, STAHLHUT, Mark, VACCA, Joseph P, DIMUZIO, Jillian, FANDOZZI, Christine, GRAHAM, Donald J, HAZUDA, Daria, KATHERINE HOLLOWAY, M, LUDMERER, Steven W, MCCAULEY, John A, MCINTYRE, Charles J
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Journal Article
Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees
CARROLL, Steven S, LUDMERER, Steven, HANDT, Larry, KOEPLINGER, Kenneth, ZHANG, Nanyan Rena, GRAHAM, Donald, DAVIES, Mary-Ellen, MACCOSS, Malcolm, HAZUDA, Daria, OLSEN, David B
Published in Antimicrobial Agents and Chemotherapy (01.03.2009)
Published in Antimicrobial Agents and Chemotherapy (01.03.2009)
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Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease
Liverton, Nigel J, Holloway, M. Katharine, McCauley, John A, Rudd, Michael T, Butcher, John W, Carroll, Steven S, DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F, Mao, Shi-Shan, McIntyre, Charles J, Nguyen, Kevin T, Romano, Joseph J, Stahlhut, Mark, Wan, Bang-Lin, Olsen, David B, Vacca, Joseph P
Published in Journal of the American Chemical Society (09.04.2008)
Published in Journal of the American Chemical Society (09.04.2008)
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Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents
OLSEN, David B, DAVIES, Mary-Ellen, CARROLL, Steven S, HANDT, Larry, KOEPLINGER, Kenneth, RENA ZHANG, Nanyan, LUDMERER, Steven W, GRAHAM, Donald, LIVERTON, Nigel, MACCOSS, Malcolm, HAZUDA, Daria
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs
Carroll, Steven S, Tomassini, Joanne E, Bosserman, Michele, Getty, Krista, Stahlhut, Mark W, Eldrup, Anne B, Bhat, Balkrishen, Hall, Dawn, Simcoe, Amy L, LaFemina, Robert, Rutkowski, Carrie A, Wolanski, Bohdan, Yang, Zhucheng, Migliaccio, Giovanni, De Francesco, Raffaele, Kuo, Lawrence C, MacCoss, Malcolm, Olsen, David B
Published in The Journal of biological chemistry (04.04.2003)
Published in The Journal of biological chemistry (04.04.2003)
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A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties
OLSEN, David B, ELDRUP, Anne B, GROBLER, Jay A, LAFEMINA, Robert L, MARKEL, Eric J, MIGLIACCIO, Giovanni, PRHAVC, Marija, STAHLHUT, Mark W, TOMASSINI, Joanne E, MACCOSS, Malcolm, HAZUDA, Daria J, CARROLL, Steven S, BARTHOLOMEW, Linda, BHAT, Balkrishen, BOSSERMAN, Michele R, CECCACCI, Alessandra, COLWELL, Lawrence F, FAY, John F, FLORES, Osvaldo A, GETTY, Krista L
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
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Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication
Eldrup, Anne B, Prhavc, Marija, Brooks, Jennifer, Bhat, Balkrishen, Prakash, Thazha P, Song, Quanlai, Bera, Sanjib, Bhat, Neelima, Dande, Prasad, Cook, P. Dan, Bennett, C. Frank, Carroll, Steven S, Ball, Richard G, Bosserman, Michele, Burlein, Christine, Colwell, Lawrence F, Fay, John F, Flores, Osvaldo A, Getty, Krista, LaFemina, Robert L, Leone, Joseph, MacCoss, Malcolm, McMasters, Daniel R, Tomassini, Joanne E, von Langen, Derek, Wolanski, Bohdan, Olsen, David B
Published in Journal of medicinal chemistry (07.10.2004)
Published in Journal of medicinal chemistry (07.10.2004)
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Journal Article
Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase
Eldrup, Anne B, Allerson, Charles R, Bennett, C. Frank, Bera, Sanjib, Bhat, Balkrishen, Bhat, Neelima, Bosserman, Michele R, Brooks, Jennifer, Burlein, Christine, Carroll, Steven S, Cook, P. Dan, Getty, Krista L, MacCoss, Malcolm, McMasters, Daniel R, Olsen, David B, Prakash, Thazha P, Prhavc, Marija, Song, Quanlai, Tomassini, Joanne E, Xia, Jie
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides
TOMEI, Licia, ALTAMURA, Sergio, KOCH, Uwe, DE FRANCESCO, Raffaele, OLSEN, David B, CARROLL, Steven S, MIGLIACCIO, Giovanni, BARTHOLOMEW, Linda, BISBOCCI, Monica, BAILEY, Carolyn, BOSSERMAN, Michele, CELLUCCI, Antonella, FORTE, Eleonora, INCITTI, Ilario, ORSATTI, Laura
Published in Journal of Virology (01.01.2004)
Published in Journal of Virology (01.01.2004)
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Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid
Shaw-Reid, Cathryn A, Munshi, Vandna, Graham, Pia, Wolfe, Abigail, Witmer, Marc, Danzeisen, Renee, Olsen, David B, Carroll, Steven S, Embrey, Mark, Wai, John S, Miller, Michael D, Cole, James L, Hazuda, Daria J
Published in The Journal of biological chemistry (31.01.2003)
Published in The Journal of biological chemistry (31.01.2003)
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Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees
CARROLL, Steven S, KOEPLINGER, Kenneth, FUJITAKI, James M, BOYER, Serge H, LINEMEYER, David L, HECKER, Scott J, ERION, Mark D, VAVREK, Marissa, NANYAN RENA ZHANG, HANDT, Laurence, MACCOSS, Malcolm, OLSEN, David B, RAJA REDDY, K, ZHILI SUN, VAN POELJE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Journal Article
Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease
McCauley, John A, Rudd, Michael T, Nguyen, Kevin T, McIntyre, Charles J, Romano, Joseph J, Bush, Kimberly J, Varga, Sandor L, Ross, Charles W. III, Carroll, Steven S, DiMuzio, Jillian, Stahlhut, Mark W, Olsen, David B, Lyle, Terry A, Vacca, Joseph P, Liverton, Nigel J
Published in Angewandte Chemie (International ed.) (01.01.2008)
Published in Angewandte Chemie (International ed.) (01.01.2008)
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Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1
Balibar, Carl J, Klein, Daniel J, Zamlynny, Beata, Diamond, Tracy L, Fang, Zhiyu, Cheney, Carol A, Kristoff, Jan, Lu, Meiqing, Bukhtiyarova, Marina, Ou, Yangsi, Xu, Min, Ba, Lei, Carroll, Steven S, El Marrouni, Abdellatif, Fay, John F, Forster, Ashley, Goh, Shih Lin, Gu, Meigang, Krosky, Daniel, Rosenbloom, Daniel I S, Sheth, Payal, Wang, Deping, Wu, Guoxin, Zebisch, Matthias, Zhao, Tian, Zuck, Paul, Grobler, Jay, Hazuda, Daria J, Howell, Bonnie J, Converso, Antonella
Published in Science translational medicine (22.02.2023)
Published in Science translational medicine (22.02.2023)
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Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Inhibitory Effect of 2′-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells
TOMASSINI, Joanne E, GETTY, Krista, MCMASTERS, Daniel R, MIGLIACCIO, Giovanni, OLSEN, David B, STAHLHUT, Mark W, SHIM, Sung, BHAT, Balkrishen, ELDRUP, Anne B, PRAKASH, Thazha P, CARROLL, Steven S, FLORES, Osvaldo, MACCOSS, Malcolm
Published in Antimicrobial Agents and Chemotherapy (01.05.2005)
Published in Antimicrobial Agents and Chemotherapy (01.05.2005)
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Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Su, Hua-Poo, Rickert, Keith, Burlein, Christine, Narayan, Kartik, Bukhtiyarova, Marina, Hurzy, Danielle M., Stump, Craig A., Zhang, Xufang, Reid, John, Krasowska-Zoladek, Alicja, Tummala, Srivanya, Shipman, Jennifer M., Kornienko, Maria, Lemaire, Peter A., Krosky, Daniel, Heller, Amanda, Achab, Abdelghani, Chamberlin, Chad, Saradjian, Peter, Sauvagnat, Berengere, Yang, Xianshu, Ziebell, Michael R., Nickbarg, Elliott, Sanders, John M., Bilodeau, Mark T., Carroll, Steven S., Lumb, Kevin J., Soisson, Stephen M., Henze, Darrell A., Cooke, Andrew J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
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A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV‑1 Infected Cells
Moore, Keith P., Schwaid, Adam G., Tudor, Matthew, Park, Sangho, Beshore, Douglas C., Converso, Antonella, Shipe, William D., Anand, Rajan, Lan, Ping, Moningka, Remond, Rothman, Deborah M., Sun, Wanying, Chi, An, Cornella-Taracido, Ivan, Adam, Gregory C., Bahnck-Teets, Carolyn, Carroll, Steven S., Fay, John F., Goh, Shih Lin, Lusen, Jeffrey, Quan, Shuo, Rodriguez, Silveria, Xu, Min, Andrews, Christine L., Song, Cheng, Filzen, Tracey, Li, Jing, Hollenstein, Kaspar, Klein, Daniel J., Lammens, Alfred, Lim, U-Ming, Fang, Zhiyu, McHale, Carolyn, Li, Yuan, Lu, Meiqing, Diamond, Tracy L., Howell, Bonnie J., Zuck, Paul, Balibar, Carl J.
Published in ACS chemical biology (16.09.2022)
Published in ACS chemical biology (16.09.2022)
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Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors
Ganguly, Ashit K, Alluri, Sesha S, Caroccia, Danielle, Biswas, Dipshikha, Wang, Chih-Hung, Kang, Eunhee, Zhang, Yong, McPhail, Andrew T, Carroll, Steven S, Burlein, Christine, Munshi, Vandna, Orth, Peter, Strickland, Corey
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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