Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Journal Article
The deubiquitylase USP9X controls ribosomal stalling
Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J, Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P, O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A, Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M, Urbé, Sylvie, Clague, Michael J
Published in The Journal of cell biology (01.03.2021)
Published in The Journal of cell biology (01.03.2021)
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Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists
Smalley, Terrence L., Boggs, Sharon, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Kaldor, Istvan, Parks, Derek J.
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene
Bass, Jonathan Y., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Mills, Wendy Y., Navas, Frank, Parks, Derek J., Smalley, Terrence L., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway
Baker, Keith D., Shewchuk, Lisa M., Kozlova, Tatiana, Makishima, Makoto, Hassell, Annie, Wisely, Bruce, Caravella, Justin A., Lambert, Millard H., Reinking, Jeffrey L., Krause, Henry, Thummel, Carl S., Willson, Timothy M., Mangelsdorf, David J.
Published in Cell (13.06.2003)
Published in Cell (13.06.2003)
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Journal Article
FXR agonist activity of conformationally constrained analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article
Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene
Akwabi-Ameyaw, Adwoa, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Journal Article
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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Journal Article
Structure-Guided Design of Antibodies
Caravella, Justin A, Wang, Deping, Glaser, Scott M, Lugovskoy, Alexey
Published in Current computer-aided drug design (01.06.2010)
Published in Current computer-aided drug design (01.06.2010)
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Journal Article
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors
Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Journal Article
Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure
Jaye, Michael C, Krawiec, John A, Campobasso, Nino, Smallwood, Angela, Qiu, Chunyan, Lu, Quinn, Kerrigan, John J, De Los Frailes Alvaro, Maite, Laffitte, Bryan, Liu, Wu-Schyong, Marino, Joseph P, Meyer, Craig R, Nichols, Jason A, Parks, Derek J, Perez, Paloma, Sarov-Blat, Lea, Seepersaud, Sheila D, Steplewski, Klaudia M, Thompson, Scott K, Wang, Ping, Watson, Mike A, Webb, Christine L, Haigh, David, Caravella, Justin A, Macphee, Colin H, Willson, Timothy M, Collins, Jon L
Published in Journal of medicinal chemistry (25.08.2005)
Published in Journal of medicinal chemistry (25.08.2005)
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Journal Article
Correction: The deubiquitylase USP9X controls ribosomal stalling
Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J, Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P, O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A, Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M, Urbé, Sylvie, Clague, Michael J
Published in The Journal of cell biology (01.03.2021)
Published in The Journal of cell biology (01.03.2021)
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Long-Range Electrostatic Contributions to Protein−Ligand Binding Estimated Using Protein Charge Ladders, Affinity Capillary Electrophoresis, and Continuum Electrostatic Theory
Caravella, Justin A, Carbeck, Jeffrey D, Duffy, David C, Whitesides, George M, Tidor, Bruce
Published in Journal of the American Chemical Society (12.05.1999)
Published in Journal of the American Chemical Society (12.05.1999)
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Journal Article
Dynamic Structural Changes Are Observed upon Collagen and Metal Ion Binding to the Integrin α1 I Domain
Weinreb, Paul H., Li, Sheng, Gao, Sharon X., Liu, Tong, Pepinsky, R.Blake, Caravella, Justin A., Lee, Jun H., Woods, Virgil L.
Published in The Journal of biological chemistry (21.09.2012)
Published in The Journal of biological chemistry (21.09.2012)
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The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily
Maglich, Jodi M., Caravella, Justin A., Lambert, Millard H., Willson, Timothy M., Moore, John T., Ramamurthy, Lakshman
Published in Nucleic acids research (15.07.2003)
Published in Nucleic acids research (15.07.2003)
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Journal Article
Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity
Chao, Esther Y, Caravella, Justin A, Watson, Mike A, Campobasso, Nino, Ghisletti, Serena, Billin, Andrew N, Galardi, Cristin, Wang, Ping, Laffitte, Bryan A, Iannone, Marie A, Goodwin, Bryan J, Nichols, Jason A, Parks, Derek J, Stewart, Eugene, Wiethe, Robert W, Williams, Shawn P, Smallwood, Angela, Pearce, Kenneth H, Glass, Christopher K, Willson, Timothy M, Zuercher, William J, Collins, Jon L
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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