Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation
Capotondo, Alessia, Milazzo, Rita, Politi, Letterio Salvatore, Quattrini, Angelo, Palini, Alessio, Plati, Tiziana, Merella, Stefania, Nonis, Alessandro, di Serio, Clelia, Montini, Eugenio, Naldini, Luigi, Biffi, Alessandra
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (11.09.2012)
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Therapeutic efficacy of intracerebral hematopoietic stem cell gene therapy in an Alzheimer’s disease mouse model
Milazzo, Rita, Montepeloso, Annita, Kumar, Rajesh, Ferro, Francesca, Cavalca, Eleonora, Rigoni, Pietro, Cabras, Paolo, Ciervo, Yuri, Das, Sabyasachi, Capotondo, Alessia, Pellin, Danilo, Peviani, Marco, Biffi, Alessandra
Published in Nature communications (13.09.2024)
Published in Nature communications (13.09.2024)
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Journal Article
Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
Rossi, Chiara, Cusimano, Melania, Zambito, Martina, Finardi, Annamaria, Capotondo, Alessia, Garcia-Manteiga, Jose Manuel, Comi, Giancarlo, Furlan, Roberto, Martino, Gianvito, Muzio, Luca
Published in Cell death & disease (14.02.2018)
Published in Cell death & disease (14.02.2018)
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Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury
Cusimano, Melania, Brambilla, Elena, Capotondo, Alessia, De Feo, Donatella, Tomasso, Antonio, Comi, Giancarlo, D'Adamo, Patrizia, Muzio, Luca, Martino, Gianvito
Published in Journal of neuroinflammation (23.02.2018)
Published in Journal of neuroinflammation (23.02.2018)
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Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice
Biffi, Alessandra, Capotondo, Alessia, Fasano, Stefania, del Carro, Ubaldo, Marchesini, Sergio, Azuma, Hisaya, Malaguti, Maria Chiara, Amadio, Stefano, Brambilla, Riccardo, Grompe, Markus, Bordignon, Claudio, Quattrini, Angelo, Naldini, Luigi
Published in The Journal of clinical investigation (01.11.2006)
Published in The Journal of clinical investigation (01.11.2006)
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Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
Gullotta, Giorgia Serena, De Feo, Donatella, Friebel, Ekaterina, Semerano, Aurora, Scotti, Giulia Maria, Bergamaschi, Andrea, Butti, Erica, Brambilla, Elena, Genchi, Angela, Capotondo, Alessia, Gallizioli, Mattia, Coviello, Simona, Piccoli, Marco, Vigo, Tiziana, Della Valle, Patrizia, Ronchi, Paola, Comi, Giancarlo, D’Angelo, Armando, Maugeri, Norma, Roveri, Luisa, Uccelli, Antonio, Becher, Burkhard, Martino, Gianvito, Bacigaluppi, Marco
Published in Nature immunology (01.06.2023)
Published in Nature immunology (01.06.2023)
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Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection
Biffi, Alessandra, Bartolomae, Cynthia C., Cesana, Daniela, Cartier, Natalie, Aubourg, Patrik, Ranzani, Marco, Cesani, Martina, Benedicenti, Fabrizio, Plati, Tiziana, Rubagotti, Enrico, Merella, Stefania, Capotondo, Alessia, Sgualdino, Jacopo, Zanetti, Gianluigi, von Kalle, Christof, Schmidt, Manfred, Naldini, Luigi, Montini, Eugenio
Published in Blood (19.05.2011)
Published in Blood (19.05.2011)
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Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings
Petrillo, Carolina, Calabria, Andrea, Piras, Francesco, Capotondo, Alessia, Spinozzi, Giulio, Cuccovillo, Ivan, Benedicenti, Fabrizio, Naldini, Luigi, Montini, Eugenio, Biffi, Alessandra, Gentner, Bernhard, Kajaste-Rudnitski, Anna
Published in Human gene therapy (01.09.2019)
Published in Human gene therapy (01.09.2019)
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Genetic Engineering of Hematopoietic Progenitor Stem Cells for Targeted IFN-α Immunotherapy Reprogramming the Solid Tumor Microenvironment: A First-in-Man Study in Glioblastoma Multiforme (NCT03866109)
Farina, Francesca, Gentner, Bernhard, Finocchiaro, Gaetano, Eoli, Marica, Capotondo, Alessia, Anghileri, Elena, Barcella, Matteo, Brambilla, Valentina, Carrabba, Matteo Giovanni, Cuccarini, Valeria, D'Alessandris, Quintino Giorgio, Di Meco, Francesco, Ferla, Valeria, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico Giuseppe, Mazzoleni, Stefania, Olivi, Alessandro, Pallini, Roberto, Saini, Massimo, Mullen, Karen, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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CTIM-22. MEDIAN AND 2 YEARS SURVIVAL OF NEWLY DIAGNOSED UNMETHYLATED MGMT GLIOBLASTOMA PATIENTS TREATED WITH TEMFERON IMMUNO-GENE THERAPY
Eoli, Marica, Farina, Francesca, Cuccarini, Valeria, Gentner, Bernhard, Barcella, Matteo, Anghileri, Elena, Bruzzone, Maria Grazia, Carrabba, Matteo, D’Alessandris, Quintino Giorgio, DiMeco, Francesco, Ferla, Valeria, Franzin, Alberto, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Francesco, Capotondo, Alessia, Mazzoleni, Stefania, Mortini, Pietro, Olivi, Alessandro, Pallini, Roberto, Patanè, Monica, Paterra, Rosina, Pollo, Bianca, Saini, Marco, Snider, Silvia, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio, Finocchiaro, Gaetano
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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TEM-MM-101: A Phase I/IIa Dose Escalation Study Evaluating the Safety and Activity of Autologous CD34+ Enriched Hematopoietic Progenitor Cells Genetically Modified for Human Interferon-α2 in Multiple Myeloma Patients with Early Relapse after Intensive Front Line Therapy
Gentner, Bernhard, Farina, Francesca, Carrabba, Matteo Giovanni, Marcatti, Magda, Girlanda, Stefania, Antonarelli, Gabriele, Alessia, Capotondo, Mazzoleni, Stefania, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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CTIM-26. IMPACT ON SURVIVAL OF INTERFERON-ALPHA DELIVERY IN GLIOBLASTOMA WITH UNMETHYLATED MGMT BY IMMUNO-GENE THERAPY WITH TEMFERON
Finocchiaro, Gaetano, Cuccarini, Valeria, Gentner, Bernhard, Capotondo, Alessia, Farina, Francesca, Naldini, Matteo Maria, Barcella, Matteo, Anghileri, Elena, Bruzzone, Maria Grazia, Carrabba, Matteo, D'alessandris, Quintino Giorgio, Meco, Francesco Di, Ferla, Valeria, Franzin, Alberto, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico, Mazzoleni, Stefania, Mortini, Pietro, Olivi, Alessandro, Pallini, Roberto, Patanè, Monica, Paterra, Rosina, Pollo, Bianca, Saini, Marco, Snider, Silvia, Mullen, Karen, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio, Eoli, Marica
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Journal Article
Reprogramming Macrophages Using Autologous Hematopoietic Stem Cells As Immunotherapy for Glioblastoma: TEM-GBM Study (NCT03866109)
Farina, Francesca, Gentner, Bernhard, Finocchiaro, Gaetano, Eoli, Marica, Capotondo, Alessia, Anghileri, Elena, Barcella, Matteo, Brambilla, Valentina, Bruzzone, Maria Grazie, Carrabba, Matteo Giovanni, Cuccarini, Valeria, D'Alessandris, Giorgio, Di Meco, Francesco, Ferla, Valeria, Franzin, Alberto, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico, Mazzoleni, Stefania, Mortini, Pietro, Naldini, Matteo Maria, Olivi, Alessandro, Pallini, Roberto, Patanè, Monica, Paterra, Rosina, Pollo, Bianca, Saini, Marco, Snider, Silvia, Zambanini, Andrew, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Abstract CT180: Changes in immunologic responses and in the tumor microenvironment in patients with glioblastoma multiforme treated with IFN-a immune cell and gene therapy (TEM-GBM_001 Study)
Gentner, Bernhard, Finocchiaro, Gaetano, Farina, Francesca, Capotondo, Alessia, Eoli, Marica, Anghileri, Elena, Ganzetti, Maya, Carabba, Matteo, Cuccarini, Valeria, Meco, Francesco Di, Legnani, Federico, Pollo, Bianca, Bruzzone, Maria Grazia, Saini, Marco, Ferroli, Paolo, Pallini, Roberto, Olivi, Alessandro, Paterra, Rosina, Garramone, Mariagrazia, Mazzoleni, Stefania, Brambilla, Valentina, Magnani, Tiziana, Antonarelli, Gabriele, Naldini, Matteo, Barcella, Matteo, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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A phase I-IIa study of genetically modified Tie-2 expressing monocytes in patients with glioblastoma multiforme (TEM-GBM Study)
Finocchiaro, Gaetano, Gentner, Bernhard, Farina, Francesca, Capotondo, Alessia, Eoli, Marica, Anghileri, Elena, Carabba, Matteo Giovanni, Cuccarini, Valeria, DI Meco, Francesco, Legnani, Federico, Pollo, Bianca, Bruzzone, Maria Grazia, Saini, Marco, Ferroli, Paolo, Pallini, Roberto, Olivi, Alessandro, Mazzoleni, Stefania, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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TEM-GBM: An Open-Label, Phase I/IIa Dose-Escalation Study Evaluating the Safety and Efficacy of Genetically Modified Tie-2 Expressing Monocytes to Deliver IFN-α within Glioblastoma Tumor Microenvironment
Gentner, Bernhard, Finocchiaro, Gaetano, Farina, Francesca, Eoli, Marica, Alessia, Capotondo, Anghileri, Elena, Antonarelli, Gabriele, Barcella, Matteo, Bruzzone, Maria Grazia, Carrabba, Matteo Giovanni, Cuccarini, Valeria, D'Alessandris, Giorgio, Di Meco, Francesco, Ferla, Valeria, Ferroli, Paolo, Gagliardi, Filippo, Garramone, Mariagrazia, Legnani, Federico, Mortini, Pietro, Naldini, Matteo Maria, Olivi, Alessandro, Pallini, Roberto, Patanè, Monica, Paterra, Rosina, Pollo, Bianca, Saini, Marco, Snider, Silvia, Brambilla, Valentina, Magnani, Tiziana, Mazzoleni, Stefania, Bashir, Zahid, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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CTIM-19. TEM-GBM: A PHASE I-IIA DOSE-ESCALATION STUDY DELIVERING IFN-Α WITHIN GLIOBLASTOMA MULTIFORME TUMOR MICROENVIRONMENT BY GENETICALLY MODIFIED TIE-2 EXPRESSING MONOCYTES
Finocchiaro, Gaetano, Gentner, Bernhard, Marica, Eoli, Francesca, Farina, Capotondo, Alessia, Ferla, Valeria, Carrabba, Matteo, Cuccarini, Valeria, Meco, Francesco Di, Legnani, Federico, Pollo, Bianca, Saini, Marco, Ferroli, Paolo, Pallini, Roberto, D'Alessandris, Giorgio, Patanè, Monica, Paterra, Rosina, Garramone, Mariagrazia, Antonarelli, Gabriele, Naldini, Matteo, Barcella, Matteo, Brambilla, Valentina, Magnani, Tiziana, Mazzoleni, Stefania, Bashir, Zahid, Olivi, Alessandro, Bruzzone, Mariagrazia, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
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CTIM-24. AUTOLOGOUS CD34+ ENRICHED HEMATOPOIETIC PROGENITOR CELLS GENETICALLY MODIFIED FOR HUMAN INTERFERON-α2, ARE WELL TOLERATED & RAPIDLY ENGRAFT IN PATIENTS WITH GLIOBLASTOMA MULTIFORME (TEM-GBM_001 STUDY)
Finocchiaro, Gaetano, Gentner, Bernhard, Eoli, Marica, Francesca, Farina, Anghileri, Elena, Girlanda, Stefania, Carrabba, Matteo, Cuccarini, Valeria, DiMeco, Francesco, Legnani, Federico, Pollo, Bianca, Bruzzone, Maria Grazia, Saini, Marco, Ferroli, Paolo, Capotondo, Alessia, Paterra, Rosina, Garramone, Mariagrazia, Mazzoleni, Stefania, Zambanini, Andrew, Russo, Carlo, Naldini, Luigi, Ciceri, Fabio
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
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Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells
Capotondo, Alessia, Milazzo, Rita, Garcia-Manteiga, Jose M, Cavalca, Eleonora, Montepeloso, Annita, Garrison, Brian S, Peviani, Marco, Rossi, Derrick J, Biffi, Alessandra
Published in Science advances (01.12.2017)
Published in Science advances (01.12.2017)
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Abstract CT127: A macrophages-based immunotherapy of solid tumors microenvironment: Preliminary results of the TEM-GBM_01 study
Farina, Francesca, Gentner, Bernhard, Finocchiaro, Gaetano, Eoli, Marica, Capotondo, Alessia, Anghileri, Elena, Barcella, Matteo, Brambilla, Valentina, Carrabba, Matteo, Cuccarini, Valeria, D'alessandris, Quintino Giorgio, DiMeco, Francesco, Ferla, Valeria, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico, Mazzoleni, Stefania, Olivi, Alessandro, Pallini, Roberto, Saini, Marco, Naldini, Luigi, Russo, Carlo, Ciceri, Fabio
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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