Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
Singh, Manisha, Vianden, Christina, Cantwell, Mark J., Dai, Zhimin, Xiao, Zhilan, Sharma, Meenu, Khong, Hiep, Jaiswal, Ashvin R., Faak, Faisal, Hailemichael, Yared, Janssen, L. M. E., Bharadwaj, Uddalak, Curran, Michael A., Diab, Adi, Bassett, Roland L., Tweardy, David J., Hwu, Patrick, Overwijk, Willem W.
Published in Nature communications (13.11.2017)
Published in Nature communications (13.11.2017)
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Journal Article
Oncolytic adenovirus MEM-288 encoding membrane-stable CD40L and IFNβ induces an anti-tumor immune response in high grade serous ovarian cancer
Peters, Pamela N., Whitaker, Regina S., Lim, Felicia, Russell, Shonagh, Bloom, Elizabeth A., Pollara, Justin, Strickland, Kyle C., Cantwell, Mark J., Beg, Amer, Berchuck, Andrew, Antonia, Scott, Previs, Rebecca A.
Published in Neoplasia (New York, N.Y.) (01.11.2024)
Published in Neoplasia (New York, N.Y.) (01.11.2024)
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Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
Fukuda, Tetsuya, Chen, Liguang, Endo, Tomoyuki, Tang, Li, Lu, Desheng, Castro, Januario E, Widhopf, George F. II, Rassenti, Laura Z, Cantwell, Mark J, Prussak, Charles E, Carson, Dennis A, Kipps, Thomas J
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2008)
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Journal Article
IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma
Singh, Shubhra, Xiao, Zhilan, Bavisi, Karishma, Roszik, Jason, Melendez, Brenda D, Wang, Zhiqiang, Cantwell, Mark J, Davis, Richard E, Lizee, Greg, Hwu, Patrick, Neelapu, Sattva S, Overwijk, Willem W, Singh, Manisha
Published in The Journal of immunology (1950) (15.04.2021)
Published in The Journal of immunology (1950) (15.04.2021)
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Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity
Zheng, Hong, Yu, Xiaoqing, Ibrahim, Mohammed L, Foresman, Dana, Xie, Mengyu, Johnson, Joseph O, Boyle, Theresa A, Ruffell, Brian, Perez, Bradford A, Antonia, Scott J, Ready, Neal, Saltos, Andreas N, Cantwell, Mark J, Beg, Amer A
Published in Cancer immunology research (03.04.2023)
Published in Cancer immunology research (03.04.2023)
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629-D The anti-tumor activity of IFNβ and membrane-stable CD40L expressing oncolytic virus MEM-288 in NSCLC patients is associated with modulation of the tumor microenvironment and systemic immune response
Saltos, Andreas N, Arrowood, Christy, Beasley, Georgia M, Ronald, James, El-Haddad, Ghassan, Gray, Jhanelle E, Pellini, Bruna, Tanvetyanon, Tawee, Guerra-Guevara, Luiziane, Khan, Uzma, Wolf, Steven, Gu, Lin, Wang, Xiaofei, Zheng, Hong, Foresman, Dana, Yu, Xiaoqing, Cantwell, Mark J, Antonia, Scott J, Beg, Amer A, Ready, Neal E
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia
Wierda, William G., Cantwell, Mark J., Woods, Sandra J., Rassenti, Laura Z., Prussak, Charles E., Kipps, Thomas J.
Published in Blood (01.11.2000)
Published in Blood (01.11.2000)
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5.54 Ad-ISF35 Transduced Autologous Cells Induce Chemosensitization Activity and Complete Responses in Fludarabine-Refractory and/or del(17p)/p53-Defective Chronic Lymphocytic Leukemia Patients
Melo-Cardenas, Johanna, Barajas-Gamboa, Juan S, Urquiza, Mauricio, Cantwell, Mark J, Kipps, Thomas J, Castro, Januario E
Published in Clinical lymphoma, myeloma and leukemia (01.10.2011)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2011)
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Abstract 697: Defining anti-tumor immune stimulatory mechanisms of MEM-288, a CD40 ligand and IFN-beta dual-transgene armed oncolytic adenovirus
Zheng, Hong, Powell, Chase D., Antonia, Scott, Cantwell, Mark J., Perez, Bradford A., Beg, Amer A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 4578: Development of MEM-288, a dual-transgene armed and conditionally replication-enhanced oncolytic adenovirus with potent systemic antitumor immunity
Zheng, Hong, Dai, Wenjie, Antonia, Scott, Cantwell, Mark J., Beg, Amer A.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Correction: IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma
Singh, Shubhra, Xiao, Zhilan, Bavisi, Karishma, Roszik, Jason, Melendez, Brenda D, Wang, Zhiqiang, Cantwell, Mark J, Davis, Richard E, Lizee, Greg, Hwu, Patrick, Neelapu, Sattva S, Overwijk, Willem W, Singh, Manisha
Published in The Journal of immunology (1950) (01.02.2024)
Published in The Journal of immunology (1950) (01.02.2024)
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Journal Article
A phase 1 first-in-human study of interferon beta (IFNβ) and membrane-stable CD40L expressing oncolytic virus (MEM-288) in solid tumors including non–small-cell lung cancer (NSCLC)
Saltos, Andreas Nicholas, Arrowood, Christy, Beasley, Georgia, Ronald, James, El-Haddad, Ghassan, Guerra-Guevara, Luiziane, Khan, Uzma, Wolf, Steven, Gu, Lin, Wang, Xiaofei F., Foresman, Dana, Yu, Xiaoqing, Cantwell, Mark J., Antonia, Scott Joseph, Beg, Amer A, Ready, Neal E.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Abstract 6655: Oncolytic adenovirus dually expressing interferon beta and membrane-stable CD40 ligand increases polyfunctional CD8+T cells associated with antitumor activity
Cantwell, Mark J., Saltos, Andreas N., Zheng, Hong, Foresman, Dana, Beg, Amer A.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 3542: Oncolytic adenovirus encoding transgenes for IFN-beta and recombinant CD40 ligand promotes conventional dendritic cell activation and trafficking with enhanced tumor infiltrating lymphocytes for effective cancer immunotherapy
Zheng, Hong, Antonia, Scott, Cantwell, Mark J., Yu, Xiaoqing, Beg, Amer A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract CT103: A phase 1 first-in-human study of MEM-288 oncolytic virus in solid tumors including non-small cell lung cancer (NSCLC): impact on tumor and systemic T cell immunity
Saltos, Andreas N., Arrowood, Christy, Beasley, Georgia, Ronald, James, El-Haddad, Ghassan, Khan, Uzma, Guerra-Guevara, Luiziane, Wolf, Steven, Gu, Lin, Wang, Xiaofei F., Foresman, Dana, Yu, Xiaoqing, Cantwell, Mark J., Antonia, Scott J., Beg, Amer A., Ready, Neal E.
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia
Wierda, William G., Cantwell, Mark J., Woods, Sandra J., Rassenti, Laura Z., Prussak, Charles E., Kipps, Thomas J.
Published in Blood (01.11.2000)
Published in Blood (01.11.2000)
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