Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
De Bruyn, Tom, Ufuk, Ayşe, Cantrill, Carina, Kosa, Rachel E., Bi, Yi-an, Niosi, Mark, Modi, Sweta, Rodrigues, A. David, Tremaine, Larry M., Varma, Manthena V. S., Galetin, Aleksandra, Houston, J. Brian
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Journal Article
Fundamental aspects of DMPK optimization of targeted protein degraders
Cantrill, Carina, Chaturvedi, Prasoon, Rynn, Caroline, Petrig Schaffland, Jeannine, Walter, Isabelle, Wittwer, Matthias B.
Published in Drug discovery today (01.06.2020)
Published in Drug discovery today (01.06.2020)
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Journal Article
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction
Umehara, Kenichi, Cantrill, Carina, Wittwer, Matthias Beat, Di Lenarda, Elisa, Klammers, Florian, Ekiciler, Aynur, Parrott, Neil, Fowler, Stephen, Ullah, Mohammed
Published in Drug metabolism and disposition (01.10.2020)
Published in Drug metabolism and disposition (01.10.2020)
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Journal Article
Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization
Fischer, Holger, Senn, Claudia, Ullah, Mohammed, Cantrill, Carina, Schuler, Franz, Yu, Li
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
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Journal Article
A novel antibiotic class targeting the lipopolysaccharide transporter
Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E, Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A T, Lobritz, Michael A, Bradley, Kenneth A
Published in Nature (London) (18.01.2024)
Published in Nature (London) (18.01.2024)
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Journal Article
Evaluation of the drug disposition of RO7049389 with in vitro data and human mass balance supported by physiologically based pharmacokinetic modelling
Zhang, Yuchen, Umehara, Kenichi, Romeo, Andrea A, Singh, Nand, Cantrill, Carina, Savage, Mark, Chen, Ethan, Zhang, Wen, Parrot, Neil John, Paehler, Axel
Published in British journal of clinical pharmacology (01.10.2023)
Published in British journal of clinical pharmacology (01.10.2023)
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Journal Article
Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter
Zampaloni, Claudia, Mattei, Patrizio, Bleicher, Konrad, Winther, Lotte, Thäte, Claudia, Bucher, Christian, Adam, Jean-Michel, Alanine, Alexander, Amrein, Kurt E, Baidin, Vadim, Bieniossek, Christoph, Bissantz, Caterina, Boess, Franziska, Cantrill, Carina, Clairfeuille, Thomas, Dey, Fabian, Di Giorgio, Patrick, du Castel, Pauline, Dylus, David, Dzygiel, Pawel, Felici, Antonio, García-Alcalde, Fernando, Haldimann, Andreas, Leipner, Matthew, Leyn, Semen, Louvel, Séverine, Misson, Pauline, Osterman, Andrei, Pahil, Karanbir, Rigo, Sébastien, Schäublin, Adrian, Scharf, Sebastian, Schmitz, Petra, Stoll, Theodor, Trauner, Andrej, Zoffmann, Sannah, Kahne, Daniel, Young, John A T, Lobritz, Michael A, Bradley, Kenneth A
Published in Nature (London) (25.07.2024)
Published in Nature (London) (25.07.2024)
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Journal Article
Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition
Cumming, John G., Kreis, Lukas, Kühne, Holger, Wermuth, Roger, Vercruysse, Maarten, Cantrill, Carina, Bissantz, Caterina, Qiu, Hongxia, Kramer, Christian, Andreotti, Daniele, Fossati, Giacomo
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Journal Article
Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol
Price, Roger J., Scott, Mary P., Cantrill, Carina, Higgins, Larry G., Moreau, Marjory, Yoon, Miyoung, Clewell, Harvey J., Creek, Moire R., Osimitz, Thomas G., Houston, J. Brian, Lake, Brian G.
Published in Xenobiotica (2021)
Published in Xenobiotica (2021)
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Journal Article
OX40 및 FAP를 표적으로 하는 이중특이성 항원 결합 분자
FAIGLE JANINE, KRAFT THOMAS, BACHL JUERGEN PETER, CANTRILL CARINA, RUEGER PETRA, IMHOF JUNG SABINE, POUSSE LAURENE, ZIELONKA JOERG, MARRER BERGER ESTELLE, SAM JOHANNES, DUERR HARALD, KLEIN CHRISTIAN, TUERCK DIETRICH, STAACK ROLAND, UMANA PABLO, AMANN MARIA, MOESSNER EKKEHARD, BUJOTZEK ALEXANDER
Year of Publication 11.11.2022
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Year of Publication 11.11.2022
Patent
Predicting Human Clearance of OATP substrates using Cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance
de Bruyn, Tom, Ufuk, Ayse, Cantrill, Carina, Kosa, Rachel E, Bi, Yi-An, Niosi, Mark, Modi, Sweta, Rodrigues, A David, Tremaine, Larry M, Varma, Manthena Vs, Galetin, Aleksandra, Houston, J Brian
Published in Drug metabolism and disposition (02.05.2018)
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Published in Drug metabolism and disposition (02.05.2018)
Journal Article
BISPECIFIC ANTIGEN BINDING MOLECULES TARGETING OX40 AND FAP
SAM, Johannes, TUERCK, Dietrich, UMANA, Pablo, DUERR, Harald, RUEGER, Petra, STAACK, Roland, BUJOTZEK, Alexander, ZIELONKA, Joerg, MARRER-BERGER, Estelle, CANTRILL, Carina, FAIGLE, Janine, BACHL, Juergen Peter, KRAFT, Thomas, AMANN, Maria, IMHOF-JUNG, Sabine, KLEIN, Christian, MOESSNER, Ekkehard, POUSSE, Laurene
Year of Publication 11.04.2024
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Year of Publication 11.04.2024
Patent
Bispecific antigen binding molecules targeting OX40 and FAP
Cantrill, Carina, Umana, Pablo, Marrer-Berger, Estelle, Sam, Johannes, Amann, Maria, Faigle, Janine, Imhof-Jung, Sabine, Kraft, Thomas, Moessner, Ekkehard, Bachl, Juergen Peter, Staack, Roland, Duerr, Harald, Bujotzek, Alexander, Pousse, Laurene, Rueger, Petra, Tuerck, Dietrich, Klein, Christian, Zielonka, Joerg
Year of Publication 10.10.2023
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Year of Publication 10.10.2023
Patent
BISPECIFIC ANTIGEN BINDING MOLECULES TARGETING OX40 AND FAP
SAM, Johannes, TUERCK, Dietrich, DUERR, Harald, RUEGER, Petra, STAACK, Roland, BUJOTZEK, Alexander, ZIELONKA, Joerg, MARRER-BERGER, Estelle, CANTRILL, Carina, FAIGLE, Janine, BACHL, Juergen Peter, KRAFT, Thomas, AMANN, Maria, IMHOF-JUNG, Sabine, KLEIN, Christian, UMAÑA, Pablo, MOESSNER, Ekkehard, POUSSE, Laurene
Year of Publication 08.02.2023
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Year of Publication 08.02.2023
Patent
Bispecific antigen binding molecules targeting OX40 and FAP
SAM, Johannes, TUERCK, Dietrich, DUERR, Harald, RUEGER, Petra, STAACK, Roland, BUJOTZEK, Alexander, ZIELONKA, Joerg, MARRER-BERGER, Estelle, CANTRILL, Carina, FAIGLE, Janine, BACHL, Juergen Peter, KRAFT, Thomas, AMANN, Maria, IMHOF-JUNG, Sabine, KLEIN, Christian, UMAÑA, Pablo, MOESSNER, Ekkehard, POUSSE, Laurene
Year of Publication 15.09.2022
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Year of Publication 15.09.2022
Patent