Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity
Thomas, James B, Atkinson, Robert N, Rothman, Richard B, Fix, Scott E, Mascarella, S. Wayne, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Lu, Y. -F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Journal Article
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
Zarrinmayeh, Hamideh, Nunes, Anne M, Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Schober, Douglas A, Gackenheimer, Susan L, Bruns, Robert F, Hipskind, Philip A, Britton, Thomas C, Cantrell, Buddy E, Gehlert, Donald R
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists
Zarrinmayeh, Hamideh, Zimmerman, Dennis M., Cantrell, Buddy E., Schober, Douglas A., Bruns, Robert E., Gackenheimer, Susan L., Ornstein, Paul L., Hipskind, Philip A., Britton, Thomas C., Gehlert, Donald R.
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
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Journal Article
Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
Thomas, James B, Fall, Michael J, Cooper, Julie B, Rothman, Richard B, Mascarella, S. Wayne, Xu, Heng, Partilla, John S, Dersch, Christina M, McCullough, Karen B, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Journal Article
Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)- piperidine Opioid Antagonists
Thomas, James B, Mascarella, S. Wayne, Rothman, Richard B, Partilla, John S, Xu, Heng, McCullough, Karen B, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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Journal Article
Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6
Cantrell, Buddy E, Zimmerman, Dennis M, Monn, James A, Kamboj, Rajender K, Hoo, Ken H, Tizzano, Joseph P, Pullar, Ian A, Farrell, Louise N, Bleakman, David
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Journal Article
Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists
Zimmerman, Dennis M., Cantrell, Buddy E., Smith, Edward C.R., Nixon, James A., Bruns, Robert F., Gitter, Bruce, Hipskind, Philip A., Ornstein, Paul L., Zarrinmayeh, Hamideh, Britton, Thomas C., Schober, Douglas A., Gehlert, Donald R.
Published in Bioorganic & medicinal chemistry letters (03.03.1998)
Published in Bioorganic & medicinal chemistry letters (03.03.1998)
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Journal Article
An efficient synthesis of the 4a-aryl-6-oxodecahydroisoquinolines
Cantrell, B. E, Paschal, J. W, Zimmerman, D. M
Published in Journal of organic chemistry (01.03.1989)
Published in Journal of organic chemistry (01.03.1989)
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Journal Article
Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders
Zimmerman, Dennis M, Gidda, Jaswant S, Cantrell, Buddy E, Schoepp, Darryle D, Johnson, Bryan G, Leander, J. David
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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Journal Article
Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines
Zimmerman, Dennis M, Cantrell, Buddy E, Swartzendruber, John K, Jones, Noel D, Mendelsohn, Laura G, Leander, J. David, Nickander, Rodney C
Published in Journal of medicinal chemistry (01.03.1988)
Published in Journal of medicinal chemistry (01.03.1988)
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Journal Article
Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors
Zimmerman, Dennis M, Leander, J. David, Cantrell, Buddy E, Reel, Jon K, Snoddy, John, Mendelsohn, Laurane G, Johnson, Bryan G, Mitch, Charles H
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
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Journal Article
Picenadol
Zimmerman, D.M., Smits, S.E., Hynes, M.D., Cantrell, B.E., Leander, J.D., Mendelsohn, L.G., Nickander, R.
Published in Drug and Alcohol Dependence (01.02.1985)
Published in Drug and Alcohol Dependence (01.02.1985)
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Book Review
Journal Article
N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists
Thomas, James B, Zheng, Xiaoling, Mascarella, S. Wayne, Rothman, Richard B, Dersch, Christina M, Partilla, John S, Flippen-Anderson, Judith L, George, Clifford F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (08.10.1998)
Published in Journal of medicinal chemistry (08.10.1998)
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Journal Article
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[ g]isoquinolines are opioid receptor pure antagonists
Thomas, James B., Mascarella, S.Wayne, Burgess, Jason P., Xu, Heng, McCullough, Karen B., Rothman, Richard B., Flippen-Anderson, Judith L., George, Clifford F., Cantrell, Buddy E., Zimmerman, Dennis M., Carroll, F.Ivy
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Journal Article
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity
Mitch, Charles H, Leander, J. David, Mendelsohn, Laurane G, Shaw, Walter N, Wong, David T, Cantrell, Buddy E, Johnson, Bryan G, Reel, John K, Snoddy, John D
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
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Journal Article
Characterization of the neurotoxic potential of m-methoxy-MPTP and the use of its N-ethyl analogue as a means of avoiding exposure to a possible Parkinsonism-causing agent
ZIMMERMAN, D. M, CANTRELL, B. E, REEL, J. K, HEMRICK-LUECKE, S. K, FULLER, R. W
Published in Journal of medicinal chemistry (01.08.1986)
Published in Journal of medicinal chemistry (01.08.1986)
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Journal Article
Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N. Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S. Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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Journal Article
Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists
Thomas, James B, Fix, Scott E, Rothman, Richard B, Mascarella, S. Wayne, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Journal Article
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists
Thomas, J B, Zheng, X, Mascarella, S W, Rothman, R B, Dersch, C M, Partilla, J S, Flippen-Anderson, J L, George, C F, Cantrell, B E, Zimmerman, D M, Carroll, F I
Published in Journal of medicinal chemistry (08.10.1998)
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Published in Journal of medicinal chemistry (08.10.1998)
Journal Article
Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors
Shepherd, Timothy A, Aikins, James A, Bleakman, David, Cantrell, Buddy E, Rearick, John P, Simon, Richard L, Smith, Edward C. R, Stephenson, Gregory A, Zimmerman, Dennis M, Mandelzys, Allan, Jarvie, Keith R, Ho, Ken, Deverill, Michelle, Kamboj, Rajender K
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Journal Article