Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001
Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase‑6
Togo, Takaya, Tram, Linh, Denton, Laura G., ElHilali-Pollard, Xochina, Gu, Jun, Jiang, Jinglei, Liu, Chenglei, Zhao, Yan, Zhao, Yanlong, Zheng, Yinzhe, Zheng, Yunping, Yang, Jingjing, Fan, Panpan, Arkin, Michelle R., Härmä, Harri, Sun, Deqian, Canan, Stacie S., Wheeler, Steven E., Renslo, Adam R.
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen
Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB
Bryk, Ruslana, Mundhra, Shashirekha, Jiang, Xiuju, Wood, Madeleine, Pfau, Daniel, Weber, Elaina, Park, Suna, Zhang, Li, Wilson, Colin, Van der Westhuyzen, Renier, Street, Leslie, Chibale, Kelly, Zimmerman, Matthew, Dartois, Véronique, Pastore, Nunzia, Ballabio, Andrea, Hawryluk, Natalie, Canan, Stacie, Khetani, Vikram, Camardo, Joseph, Nathan, Carl
Published in PLoS pathogens (01.06.2020)
Published in PLoS pathogens (01.06.2020)
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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.03.2007)
Published in Molecular cancer therapeutics (01.03.2007)
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Collaborative virtual screening to elaborate an imidazo[1,2-]pyridine hit series for visceral leishmaniasis
Akao, Yuichiro, Canan, Stacie, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Itono, Sachiko, Kaki, Rina, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Nakai, Hiromi, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shimada, Mitsuyuki, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Published in MedChemComm (01.04.2021)
Published in MedChemComm (01.04.2021)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization
Hawryluk, Natalie, Zhiru, Li, Carlow, Clotilde, Gokool, Suzanne, Townson, Simon, Kreiss, Tamara, Chojnowski, Agnieszka, Prorok, Monika, Siekierka, John, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Canan, Stacie, Khetani, Vikram, Zeldis, Jerome, Specht, Sabine, Hübner, Marc P., Scandale, Ivan
Published in International journal for parasitology -- drugs and drug resistance (01.08.2022)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2022)
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
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Activation of specific RXR heterodimers by an antagonist of RXR homodimers
Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A
Published in Nature (London) (03.10.1996)
Published in Nature (London) (03.10.1996)
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Strategies Employed for the Development of PARP Inhibitors
Canan, Stacie, Maegley, Karen, Curtin, Nicola J
Published in Methods in molecular biology (Clifton, N.J.) (2017)
Published in Methods in molecular biology (Clifton, N.J.) (2017)
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Collaborative Virtual Screening Identifies a 2‑Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection
Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M., Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Identification of the First Retinoid X Receptor Homodimer Antagonist
Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections
Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure
Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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연충 감염 및 질병의 치료를 위한 헤테로환식 화합물 및 이들의 용도
KYNE GRAHAM, CANAN STACIE, BEDORE MATTHEW, CONDROSKI KEVIN R, MENON SANJAY, HAWRYLUK NATALIE
Year of Publication 26.06.2023
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Year of Publication 26.06.2023
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