Endpoints and other considerations in phase I studies of targeted anticancer therapy: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT)
Booth, Christopher M, Calvert, A. Hilary, Giaccone, Giuseppe, Lobbezoo, Marinus W, Seymour, Lesley K, Eisenhauer, Elizabeth A
Published in European journal of cancer (1990) (01.01.2008)
Published in European journal of cancer (1990) (01.01.2008)
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A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules
BODDY, Alan V, PLUMMER, E. Ruth, CALVERT, A. Hilary, TODD, Radha, SLUDDEN, Julieann, GRIFFIN, Melanie, ROBSON, Lesley, CASSIDY, James, BISSETT, Donald, BERNAREGGI, Alberto, VERRILL, Mark W
Published in Clinical cancer research (01.11.2005)
Published in Clinical cancer research (01.11.2005)
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
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Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Calvert, A. Hilary, Curtin, Nicola J., Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J., Kitching, Martin S., Newell, David R., Norbedo, Stefano, Northen, Julian S., Reid, Rebecca J., Saravanan, K., Willems, Henriëtte M.G., Lunec, John
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Randomized Trial of Two Intravenous Schedules of the Topoisomerase I Inhibitor Liposomal Lurtotecan in Women With Relapsed Epithelial Ovarian Cancer: A Trial of the National Cancer Institute of Canada Clinical Trials Group
DARK, Graham G, CALVERT, A. Hilary, TRUDEAU, Marc, VASEY, Paul, HAMILTON, Marta, CAMERON, Terri, BARRETT, Emma, WALSH, Wendy, MCLNTOSH, Lynn, EISENHAUER, Elizabeth A, GRIMSHAW, Robert, POOLE, Christopher, SWENERTON, Ken, KAYE, Stan, COLEMAN, Robert, JAYSON, Gordon, LE, Tien, ELLARD, Susan
Published in Journal of clinical oncology (20.03.2005)
Published in Journal of clinical oncology (20.03.2005)
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Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331
FORD, Hugo E. R, MITCHELL, Fraser, CUNNINGHAM, David, FARRUGIA, David C, HILL, Mark E, REES, Charlotte, CALVERT, A. Hilary, JUDSON, Ian R, JACKMAN, Ann L
Published in Clinical cancer research (01.01.2002)
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Published in Clinical cancer research (01.01.2002)
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Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies
Seymour, Lesley K, Calvert, A. Hilary, Lobbezoo, Marinus W, Eisenhauer, Elizabeth A, Giaccone, Giuseppe
Published in European journal of cancer (1990) (01.05.2013)
Published in European journal of cancer (1990) (01.05.2013)
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Journal Article
Design and conduct of phase II studies of targeted anticancer therapy: Recommendations from the task force on methodology for the development of innovative cancer therapies (MDICT)
Booth, Christopher M, Calvert, A. Hilary, Giaccone, Giuseppe, Lobbezoo, Marinus W, Eisenhauer, Elizabeth A, Seymour, Lesley K
Published in European journal of cancer (1990) (01.01.2008)
Published in European journal of cancer (1990) (01.01.2008)
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Journal Article
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy
Niyikiza, Clet, Baker, Sharyn D, Seitz, David E, Walling, Jackie M, Nelson, Katrina, Rusthoven, James J, Stabler, Sally P, Paoletti, Paolo, Calvert, A Hilary, Allen, Robert H
Published in Molecular cancer therapeutics (01.05.2002)
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Published in Molecular cancer therapeutics (01.05.2002)
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Phase 0 clinical trials: Recommendations from the task force on methodology for the development of innovative cancer therapies
Kummar, Shivaani, Doroshow, James H, Tomaszewski, Joseph E, Calvert, A. Hilary, Lobbezoo, Marinus, Giaccone, Giuseppe
Published in European journal of cancer (1990) (01.03.2009)
Published in European journal of cancer (1990) (01.03.2009)
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Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1
PLUMMER, E. Ruth, MIDDLETON, Mark R, BODDY, Alan V, CALVERT, A. Hilary, HARRIS, Adrian L, NEWELL, David R, CURTIN, Nicola J, JONES, Christopher, OLSEN, Anna, HICKSON, Ian, MCHUGH, Peter, MARGISON, Geoffrey P, MCGOWN, Gail, THORNCROFT, Mary, WATSON, Amanda J
Published in Clinical cancer research (01.05.2005)
Published in Clinical cancer research (01.05.2005)
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Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase
White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors
Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Randomized cross‐over clinical trial to study potential pharmacokinetic interactions between cisplatin or carboplatin and etoposide
Thomas, Huw D., Porter, David J., Bartelink, Imke, Nobbs, Joy R., Cole, Michael, Elliott, Suzie, Newell, David R., Calvert, A. Hilary, Highley, Martin, Boddy, Alan V.
Published in British journal of clinical pharmacology (01.01.2002)
Published in British journal of clinical pharmacology (01.01.2002)
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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure
Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines
DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R
Published in Clinical cancer research (01.07.2000)
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Published in Clinical cancer research (01.07.2000)
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Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein
Saravanan, Kappusamy, Barlow, Hannah C, Barton, Marion, Calvert, A. Hilary, Golding, Bernard T, Newell, David R, Northen, Julian S, Curtin, Nicola J, Thomas, Huw D, Griffin, Roger J
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Structure-Based design of 2-Arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-Dependent kinases 1 and 2
Sayle, Kerry L., Bentley, Johanne, Boyle, F.Thomas, Calvert, A.Hilary, Cheng, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Jewsbury, Philip, Mesguiche, Veronique, Newell, David R., Noble, Martin E.M., Parsons, Rachel J., Pratt, David J., Wang, Lan Z., Griffin, Roger J.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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2-[11C]Thymidine Positron Emission Tomography as an Indicator of Thymidylate Synthase Inhibition in Patients Treated With AG337
Wells, Paula, Aboagye, Eric, Gunn, Roger N., Osman, Safiye, Boddy, Alan V., Taylor, Gordon A., Rafi, Imran, Hughes, Andrew N., Calvert, A. Hilary, Price, Pat M., Newell, David R.
Published in JNCI : Journal of the National Cancer Institute (07.05.2003)
Published in JNCI : Journal of the National Cancer Institute (07.05.2003)
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