A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates
Breen, Danna M., Kim, Hanna, Bennett, Donald, Calle, Roberto A., Collins, Susie, Esquejo, Ryan M., He, Tao, Joaquim, Stephanie, Joyce, Alison, Lambert, Matthew, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.
Published in Cell metabolism (01.12.2020)
Published in Cell metabolism (01.12.2020)
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Pharmacokinetics and pharmacodynamics of PF‐05231023, a novel long‐acting FGF21 mimetic, in a first‐in‐human study
Dong, Jennifer Q., Rossulek, Michelle, Somayaji, Veena R., Baltrukonis, Daniel, Liang, Yali, Hudson, Krischan, Hernandez‐Illas, Martha, Calle, Roberto A.
Published in British journal of clinical pharmacology (01.11.2015)
Published in British journal of clinical pharmacology (01.11.2015)
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Journal Article
The prevalence of low muscle mass associated with obesity in the USA
Murdock, Dana J, Wu, Ning, Grimsby, Joseph S, Calle, Roberto A, Donahue, Stephen, Glass, David J, Sleeman, Mark W, Sanchez, Robert J
Published in Skeletal muscle (21.12.2022)
Published in Skeletal muscle (21.12.2022)
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The relationship between weight gain during chemotherapy and outcomes in patients with advanced non‐small cell lung cancer
Roeland, Eric J., Fintelmann, Florian J., Hilton, Fiona, Yang, Ruoyong, Whalen, Ed, Tarasenko, Lisa, Calle, Roberto A., Bonomi, Philip D.
Published in Journal of cachexia, sarcopenia and muscle (01.06.2024)
Published in Journal of cachexia, sarcopenia and muscle (01.06.2024)
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Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants
Sawant‐Basak, Aarti, Bergman, Arthur J., Mancuso, Jessica, Tripathy, Sakambari, Gosset, James R., Mendes da Costa, Laure, Esler, William P., Calle, Roberto A.
Published in Clinical and translational science (01.02.2024)
Published in Clinical and translational science (01.02.2024)
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Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)
Deshmukh, Harshal A., Colhoun, Helen M., Johnson, Toby, McKeigue, Paul M., Betteridge, D. John, Durrington, Paul N., Fuller, John H., Livingstone, Shona, Charlton-Menys, Valentine, Neil, Andrew, Poulter, Neil, Sever, Peter, Shields, Denis C., Stanton, Alice V., Chatterjee, Aurobindo, Hyde, Craig, Calle, Roberto A., DeMicco, David A., Trompet, Stella, Postmus, Iris, Ford, Ian, Jukema, J. Wouter, Caulfield, Mark, Hitman, Graham A.
Published in Journal of lipid research (01.05.2012)
Published in Journal of lipid research (01.05.2012)
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Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate
Giragossian, Craig, Vage, Chandra, Li, Jun, Pelletier, Kathleen, Piché-Nicholas, Nicole, Rajadhyaksha, Manoj, Liras, Jennifer, Logan, Alison, Calle, Roberto A, Weng, Yan
Published in Drug metabolism and disposition (01.06.2015)
Published in Drug metabolism and disposition (01.06.2015)
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ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials
Calle, Roberto A, Amin, Neeta B, Carvajal-Gonzalez, Santos, Ross, Trenton T, Bergman, Arthur, Aggarwal, Sudeepta, Crowley, Collin, Rinaldi, Anthony, Mancuso, Jessica, Aggarwal, Naresh, Somayaji, Veena, Inglot, Malgorzata, Tuthill, Theresa A, Kou, Kou, Boucher, Magalie, Tesz, Greg, Dullea, Robert, Bence, Kendra K, Kim, Albert M, Pfefferkorn, Jeffrey A, Esler, William P
Published in Nature medicine (01.10.2021)
Published in Nature medicine (01.10.2021)
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Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis
Sanyal, Arun J, Shankar, Sudha S, Yates, Katherine P, Bolognese, James, Daly, Erika, Dehn, Clayton A, Neuschwander-Tetri, Brent, Kowdley, Kris, Vuppalanchi, Raj, Behling, Cynthia, Tonascia, James, Samir, Anthony, Sirlin, Claude, Sherlock, Sarah P, Fowler, Kathryn, Heymann, Helen, Kamphaus, Tania N, Loomba, Rohit, Calle, Roberto A
Published in Nature medicine (01.10.2023)
Published in Nature medicine (01.10.2023)
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Non-Invasive Biomarkers of Nonalcoholic Steatohepatitis: the FNIH NIMBLE project
Sanyal, Arun J, Shankar, Sudha S, Calle, Roberto A, Samir, Anthony E, Sirlin, Claude B, Sherlock, Sarah P, Loomba, Rohit, Fowler, Kathryn J, Dehn, Clayton A, Heymann, Helen, Kamphaus, Tania N
Published in Nature medicine (01.03.2022)
Published in Nature medicine (01.03.2022)
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Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates
Kim, Albert M., Somayaji, Veena R., Dong, Jennifer Q., Rolph, Timothy P., Weng, Yan, Chabot, Jeffrey R., Gropp, Kathryn E., Talukdar, Saswata, Calle, Roberto A.
Published in Diabetes, obesity & metabolism (01.12.2017)
Published in Diabetes, obesity & metabolism (01.12.2017)
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A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia
Crawford, Jeffrey, Calle, Roberto A, Collins, Susie M, Weng, Yan, Lubaczewski, Shannon L, Buckeridge, Clare, Wang, Ellen Q, Harrington, Magdalena A, Tarachandani, Anil, Rossulek, Michelle I, Revkin, James H
Published in Clinical cancer research (01.02.2024)
Published in Clinical cancer research (01.02.2024)
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Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function
Shankar, Sudha S, Lee, Douglas S, Raymond, Ralph H, Calle, Roberto A, Cobelli, Claudio, Ghosh, Atalanta, Robertson, R. Paul, Ruetten, Hartmut, Staten, Myrlene A, Stefanovski, Darko, Vella, Adrian, Whitaker, Sanya, Fryburg, David A
Published in Contemporary clinical trials communications (01.06.2018)
Published in Contemporary clinical trials communications (01.06.2018)
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Efficacy and safety of the glucagon receptor antagonist PF‐06291874: A 12‐week, randomized, dose‐response study in patients with type 2 diabetes mellitus on background metformin therapy
Kazierad, David J., Chidsey, Kristin, Somayaji, Veena R., Bergman, Arthur J., Calle, Roberto A.
Published in Diabetes, obesity & metabolism (01.11.2018)
Published in Diabetes, obesity & metabolism (01.11.2018)
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1200-P: The Prevalence of Obesity-Associated Loss of Lean Muscle Mass
MURDOCK, DANA J., WU, NING, GLASS, DAVID J., GRIMSBY, JOSEPH S., CALLE, ROBERTO A., DONAHUE, STEPHEN, SLEEMAN, MARK, SANCHEZ, ROBERT J.
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium
Fowler, Kathryn J, Venkatesh, Sudhakar K, Obuchowski, Nancy, Middleton, Michael S, Chen, Jun, Pepin, Kay, Magnuson, Jessica, Brown, Kathy J, Batakis, Danielle, Henderson, Walter C, Shankar, Sudha S, Kamphaus, Tania N, Pasek, Alex, Calle, Roberto A, Sanyal, Arun J, Loomba, Rohit, Ehman, Richard, Samir, Anthony E, Sirlin, Claude B, Sherlock, Sarah P
Published in Radiology (01.10.2023)
Published in Radiology (01.10.2023)
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Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging
Cline, Gary W., Naganawa, Mika, Chen, Laigao, Chidsey, Kristin, Carvajal-Gonzalez, Santos, Pawlak, Sylvester, Rossulek, Michelle, Zhang, Yanwei, Bini, Jason, McCarthy, Timothy J., Carson, Richard E., Calle, Roberto A.
Published in Diabetologia (01.12.2018)
Published in Diabetologia (01.12.2018)
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