Pyrrolo[2,3- d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I
Arnold, Lee D, Calderwood, David J, Dixon, Richard W, Johnston, David N, Kamens, Joanne S, Munschauer, Rainer, Rafferty, Paul, Ratnofsky, Sheldon E
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
Published in Bioorganic & medicinal chemistry letters (02.10.2000)
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Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport
Fenczik, Csilla A., Zent, Roy, Dellos, Melissa, Calderwood, David A., Satriano, Joe, Kelly, Carolyn, Ginsberg, Mark H.
Published in The Journal of biological chemistry (23.03.2001)
Published in The Journal of biological chemistry (23.03.2001)
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Journal Article
The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin
Calderwood, David A., Tuckwell, Danny S., Eble, Johannes, Kühn, Klaus, Humphries, Martin J.
Published in The Journal of biological chemistry (01.05.1997)
Published in The Journal of biological chemistry (01.05.1997)
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Journal Article
Integrin α2 I-domain is a binding site for collagens
Tuckwell, Danny, Calderwood, David A., Green, Linda J., Humphries, Martin J.
Published in Journal of cell science (01.04.1995)
Published in Journal of cell science (01.04.1995)
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Journal Article
Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3
Han, Jaewon, Lim, Chinten James, Watanabe, Naohide, Soriani, Alessandra, Ratnikov, Boris, Calderwood, David A., Puzon-McLaughlin, Wilma, Lafuente, Esther M., Boussiotis, Vassiliki A., Shattil, Sanford J., Ginsberg, Mark H.
Published in Current biology (19.09.2006)
Published in Current biology (19.09.2006)
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Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors
Hoemann, Michael, Wilson, Noel, Argiriadi, Maria, Banach, David, Burchat, Andrew, Calderwood, David, Clapham, Bruce, Cox, Phil, Duignan, David B., Konopacki, Don, Somal, Gagandeep, Vasudevan, Anil
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Journal Article
The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation
Goult, Benjamin T., Bouaouina, Mohamed, Harburger, David S., Bate, Neil, Patel, Bipin, Anthis, Nicholas J., Campbell, Iain D., Calderwood, David A., Barsukov, Igor L., Roberts, Gordon C., Critchley, David R.
Published in Journal of molecular biology (18.12.2009)
Published in Journal of molecular biology (18.12.2009)
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Abstract 1380: Setdb1 -loss reactivates ERV expression and interferon signaling to induce immune-mediated melanoma clearance
McGeary, Meaghan K., Damsky, William, Daniels, Drew, Micevic, Goran, Song, Eric, Lou, Hua Jane, Calderwood, Clotilde, Paradkar, Sateja, Iwasaki, Akiko, Calderwood, David, Turk, Benjamin, Bosenberg, Marcus
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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PAK6 targets to cell-cell adhesions via its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape
Morse, Elizabeth M., Sun, Xiaowen, Olberding, Jordan R., Ha, Byung Hak, Boggon, Titus J., Calderwood, David A.
Published in Journal of cell science (01.01.2015)
Published in Journal of cell science (01.01.2015)
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Journal Article
FAK promotes recruitment of talin to nascent adhesions to control cell motility
Lawson, Christine, Lim, Ssang-Taek, Uryu, Sean, Chen, Xiao Lei, Calderwood, David A., Schlaepfer, David D.
Published in The Journal of cell biology (06.02.2012)
Published in The Journal of cell biology (06.02.2012)
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Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-[Beta]-dependent mechanisms
Shi, Xiarong, Mihaylova, Valia T, Kuruvilla, Leena, Chen, Fang, Viviano, Stephen, Baldassarre, Massimiliano, Sperandio, David, Martinez, Ruben, Yue, Peng, Bates, Jamie G, Breckenridge, David G, Schlessinger, Joseph, Turk, Benjamin E, Calderwood, David A
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Journal Article
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYCand TGF-β–dependent mechanisms
Shi, Xiarong, Mihaylova, Valia T., Kuruvilla, Leena, Chen, Fang, Viviano, Stephen, Baldassarre, Massimiliano, Sperandio, David, Martinez, Ruben, Yue, Peng, Bates, Jamie G., Breckenridge, David G., Schlessinger, Joseph, Turk, Benjamin E., Calderwood, David A.
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
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Journal Article
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Tadokoro, Seiji, Shattil, Sanford J., Eto, Koji, Tai, Vera, Liddington, Robert C., de Pereda, José M., Ginsberg, Mark H., Calderwood, David A.
Published in Science (American Association for the Advancement of Science) (03.10.2003)
Published in Science (American Association for the Advancement of Science) (03.10.2003)
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Mechanism for KRIT1 release of ICAP1-mediated integrin activation suppression
Liu, Weizhi, Draheim, Kyle M., Zhang, Rong, Calderwood, David A., Boggon, Titus J.
Published in Molecular cell (11.01.2013)
Published in Molecular cell (11.01.2013)
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Journal Article
Differential binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation
Huet-Calderwood, Clotilde, Brahme, Nina N., Kumar, Nikit, Stiegler, Amy L., Raghavan, Srikala, Boggon, Titus J., Calderwood, David A.
Published in Journal of cell science (01.01.2014)
Published in Journal of cell science (01.01.2014)
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Journal Article
The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering: e1004756
Ellis, Stephanie J, Lostchuck, Emily, Goult, Benjamin T, Bouaouina, Mohamed, Fairchild, Michael J, López-Ceballos, Pablo, Calderwood, David A, Tanentzapf, Guy
Published in PLoS genetics (01.11.2014)
Published in PLoS genetics (01.11.2014)
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Abstract 3059: Discovery of BET family proteins as cancer targets using phenotypic-based profiling and affinity capture mass spectrometry
Warder, Scott E., McLoughlin, Shaun M., Hansen, T. Matthew, Richardson, Paul L., Wilcox, Denise M., Addo, Sadiya N., Tang, Hua, Sun, Chaohong, Petros, Andrew M., Panchal, Sanjay C., Park, Chang H., Duggan, M. Shannon, Patterson, Melanie J., Buchanan, F. Greg, Cheng, Dong, Davis, Heather M., Calderwood, David J., Elmore, Steven W., Shen, Yu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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