Search Results - "CALDERON, IMELDA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

by Rowbottom, Martin W, Bain, Gretchen, Calderon, Imelda, Lasof, Taylor, Lonergan, David, Lai, Andiliy, Huang, Fei, Darlington, Janice, Prodanovich, Patricia, Santini, Angelina M, King, Christopher D, Goulet, Lance, Shannon, Kristen E, Ma, Gina L, Nguyen, Katherine, MacKenna, Deidre A, Evans, Jilly F, Hutchinson, John H
Published in Journal of medicinal chemistry (25.05.2017)

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Journal Article

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis

by Bain, Gretchen, Shannon, Kristen E, Huang, Fei, Darlington, Janice, Goulet, Lance, Prodanovich, Patricia, Ma, Gina L, Santini, Angelina M, Stein, Adam J, Lonergan, Dave, King, Christopher D, Calderon, Imelda, Lai, Andiliy, Hutchinson, John H, Evans, Jilly F
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)

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Journal Article

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

by Semple, Graeme, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Uy, Jane, Choi, Karoline, Xiong, Yifeng, Ren, Albert, Morgan, Michael, Dave, Vibha, Thomsen, William, Unett, David J, Xing, Charles, Bossie, Stuart, Carroll, Chris, Chu, Zhi-Liang, Grottick, Andrew J, Hauser, Erin K, Leonard, James, Jones, Robert M
Published in Journal of medicinal chemistry (11.09.2008)

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Journal Article

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

by Stein, Adam J, Bain, Gretchen, Prodanovich, Pat, Santini, Angelina M, Darlington, Janice, Stelzer, Nina M P, Sidhu, Ranjinder S, Schaub, Jeffrey, Goulet, Lance, Lonergan, Dave, Calderon, Imelda, Evans, Jilly F, Hutchinson, John H
Published in Molecular pharmacology (01.12.2015)

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Journal Article

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

by Semple, Graeme, Ren, Albert, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Choi, Karoline, Xiong, Yifeng, Shin, Young-Jun, Gharbaoui, Tawfik, Sage, Carleton R., Morgan, Michael, Xing, Charles, Chu, Zhi-Liang, Leonard, James N., Grottick, Andrew J., Al-Shamma, Hussein, Liang, Yin, Demarest, Keith T., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)

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Journal Article

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

by Buzard, Daniel J, Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J, Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P, Jones, Robert M
Published in ACS medicinal chemistry letters (11.12.2014)

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Journal Article

플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도

플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도

by ROWBOTTOM MARTIN W, HUTCHINSON JOHN HOWARD, CALDERON IMELDA
Year of Publication 15.11.2017

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Patent

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

by Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang, Al-Sharmma, Hussein, Shu, Hsin-Hui, Tung, Shiu-Feng, Unett, David J., Behan, Dominic P., Yoon, Woo Hyun, Morgan, Michael, Usmani, Khawja A., Chen, Chuan, Sadeque, Abu, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.08.2015)

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Journal Article

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

by Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)

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Journal Article

Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

by Buzard, Daniel J., Han, Sangdon, Lopez, Luis, Kawasaki, Andrew, Moody, Jeanne, Thoresen, Lars, Ullman, Brett, Lehmann, Juerg, Calderon, Imelda, Zhu, Xiuwen, Gharbaoui, Tawfik, Sengupta, Dipanjan, Krishnan, Ashwin, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Thatte, Jayant, Solomon, Michelle, Fu, Lixia, Whelan, Kevin, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.07.2012)

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Journal Article

1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA

1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA

by DAVE VIBHA, XIONG YIFENG, JONES ROBERT M, UY JANE, AZIMIOARA MIHAI D, PEREIRA GUILHERME, CALDERON IMELDA, DUVVURI KAMESHWARI, CHOI JIN SUN KAROLINE, FIORAVANTI BEATRIZ, SEMPLE GRAEME
Year of Publication 07.02.2011

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Patent

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

by Calderon, Imelda, Hutchinson, John Howard, Rowbottom, Martin W
Year of Publication 27.07.2021

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Patent

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

by CALDERON, Imelda, ROWBOTTOM, Martin W, HUTCHINSON, John Howard
Year of Publication 24.03.2021

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Patent

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

by CALDERON, Imelda, ROWBOTTOM, Martin W, HUTCHINSON, John Howard
Year of Publication 18.11.2020

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Patent

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

by Calderon, Imelda, Hutchinson, John Howard, Rowbottom, Martin W
Year of Publication 10.09.2020

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Patent

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

by Calderon, Imelda, Hutchinson, John Howard, Rowbottom, Martin W
Year of Publication 10.09.2020

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Patent

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

by CALDERON, Imelda, ROWBOTTOM, Martin W, HUTCHINSON, John Howard
Year of Publication 16.04.2020

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Patent

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

by Calderon, Imelda, Hutchinson, John Howard, Rowbottom, Martin W
Year of Publication 25.02.2020

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Patent

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

by CALDERON, Imelda, ROWBOTTOM, Martin W, HUTCHINSON, John Howard
Year of Publication 25.04.2019

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Patent

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof

by Calderon, Imelda, Hutchinson, John Howard, Rowbottom, Martin W
Year of Publication 11.12.2018

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Patent

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