Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily
Schroeder, Gretchen M, An, Yongmi, Cai, Zhen-Wei, Chen, Xiao-Tao, Clark, Cheryl, Cornelius, Lyndon A. M, Dai, Jun, Gullo-Brown, Johnni, Gupta, Ashok, Henley, Benjamin, Hunt, John T, Jeyaseelan, Robert, Kamath, Amrita, Kim, Kyoung, Lippy, Jonathan, Lombardo, Louis J, Manne, Veeraswamy, Oppenheimer, Simone, Sack, John S, Schmidt, Robert J, Shen, Guoxiang, Stefanski, Kevin, Tokarski, John S, Trainor, George L, Wautlet, Barri S, Wei, Donna, Williams, David K, Zhang, Yingru, Zhang, Yueping, Fargnoli, Joseph, Borzilleri, Robert M
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Discovery of Brivanib Alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)
Cai, Zhen-wei, Zhang, Yongzheng, Borzilleri, Robert M, Qian, Ligang, Barbosa, Stephanie, Wei, Donna, Zheng, Xiaoping, Wu, Lawrence, Fan, Junying, Shi, Zhongping, Wautlet, Barri S, Mortillo, Steve, Jeyaseelan, Robert, Kukral, Daniel W, Kamath, Amrita, Marathe, Punit, D’Arienzo, Celia, Derbin, George, Barrish, Joel C, Robl, Jeffrey A, Hunt, John T, Lombardo, Louis J, Fargnoli, Joseph, Bhide, Rajeev S
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
Kim, Kyoung Soon, Zhang, Liping, Schmidt, Robert, Cai, Zhen-Wei, Wei, Donna, Williams, David K, Lombardo, Louis J, Trainor, George L, Xie, Dianlin, Zhang, Yaquan, An, Yongmi, Sack, John S, Tokarski, John S, Darienzo, Celia, Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Lippy, Jonathan, Jeyaseelan, Robert, Wautlet, Barri, Henley, Benjamin, Gullo-Brown, Johnni, Manne, Veeraswamy, Hunt, John T, Fargnoli, Joseph, Borzilleri, Robert M
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases
Bhide, Rajeev S, Lombardo, Louis J, Hunt, John T, Cai, Zhen-Wei, Barrish, Joel C, Galbraith, Susan, Jeyaseelan, Sr, Robert, Mortillo, Steven, Wautlet, Barri S, Krishnan, Bala, Kukral, Daniel, Malone, Harold, Lewin, Anne C, Henley, Benjamin J, Fargnoli, Joseph
Published in Molecular cancer therapeutics (01.02.2010)
Published in Molecular cancer therapeutics (01.02.2010)
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Journal Article
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Cai, Zhen-Wei, Wei, Donna, Schroeder, Gretchen M., Cornelius, Lyndon A.M., Kim, Kyoung, Chen, Xiao-Tao, Schmidt, Robert J., Williams, David K., Tokarski, John S., An, Yongmi, Sack, John S., Manne, Veeraswamy, Kamath, Amrita, Zhang, Yueping, Marathe, Punit, Hunt, John T., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
Perez, Heidi L., Banfi, Patrizia, Bertrand, Jay, Cai, Zhen-Wei, Grebinski, James W., Kim, Kyoung, Lippy, Jonathan, Modugno, Michele, Naglich, Joseph, Schmidt, Robert J., Tebben, Andrew, Vianello, Paola, Wei, Donna D., Zhang, Liping, Galvani, Arturo, Lombardo, Louis J., Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Journal Article
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
Schroeder, Gretchen M., Wei, Donna, Banfi, Patrizia, Cai, Zhen-Wei, Lippy, Jonathan, Menichincheri, Maria, Modugno, Michele, Naglich, Joseph, Penhallow, Becky, Perez, Heidi L., Sack, John, Schmidt, Robert J., Tebben, Andrew, Yan, Chunhong, Zhang, Liping, Galvani, Arturo, Lombardo, Louis J., Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Identification of pyrrolo[2,1- f][1,2,4]triazine-based inhibitors of Met kinase
Schroeder, Gretchen M., Chen, Xiao-Tao, Williams, David K., Nirschl, David S., Cai, Zhen-Wei, Wei, Donna, Tokarski, John S., An, Yongmi, Sack, John, Chen, Zhong, Huynh, Tram, Vaccaro, Wayne, Poss, Michael, Wautlet, Barri, Gullo-Brown, Johnni, Kellar, Kristen, Manne, Veeraswamy, Hunt, John T., Wong, Tai W., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
Kim, Kyoung Soon, Kimball, S. David, Misra, Raj N, Rawlins, David B, Hunt, John T, Xiao, Hai-Yun, Lu, Songfeng, Qian, Ligang, Han, Wen-Ching, Shan, Weifang, Mitt, Toomas, Cai, Zhen-Wei, Poss, Michael A, Zhu, Hong, Sack, John S, Tokarski, John S, Chang, Chieh Ying, Pavletich, Nikola, Kamath, Amrita, Humphreys, William G, Marathe, Punit, Bursuker, Isia, Kellar, Kristen A, Roongta, Urvashi, Batorsky, Roberta, Mulheron, Janet G, Bol, David, Fairchild, Craig R, Lee, Francis Y, Webster, Kevin R
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors
Williams, David K., Chen, Xiao-Tao, Tarby, Christine, Kaltenbach, Robert, Cai, Zhen-Wei, Tokarski, John S., An, Yongmi, Sack, John S., Wautlet, Barri, Gullo-Brown, Johnni, Henley, Benjamin J., Jeyaseelan, Robert, Kellar, Kristen, Manne, Veeraswamy, Trainor, George L., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1- f][1,2,4]triazine-based VEGFR-2 kinase inhibitors
Cai, Zhen-wei, Wei, Donna, Borzilleri, Robert M., Qian, Ligang, Kamath, Amrita, Mortillo, Steven, Wautlet, Barri, Henley, Benjamin J., Jeyaseelan, Robert, Tokarski, John, Hunt, John T., Bhide, Rajeev S., Fargnoli, Joseph, Lombardo, Louis J.
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors
Borzilleri, Robert M, Zheng, Xiaoping, Qian, Ligang, Ellis, Christopher, Cai, Zhen-wei, Wautlet, Barri S, Mortillo, Steve, Jeyaseelan, Robert, Kukral, Daniel W, Fura, Aberra, Kamath, Amrita, Vyas, Viral, Tokarski, John S, Barrish, Joel C, Hunt, John T, Lombardo, Louis J, Fargnoli, Joseph, Bhide, Rajeev S
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)- N-(2-methyl-1 H-pyrrolo[2,3- b]pyridin-5-yl)pyrrolo[2,1- f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor
Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Martel, Alain, Cai, Zhen-Wei, Wei, Donna, Qian, Ligang, Barrish, Joel C., Mathur, Arvind, D’Arienzo, Celia, Hunt, John T., Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Derbin, George, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Henley, Benjamin, Tejwani, Ravindra, Bhide, Rajeev S., Trainor, George L., Fargnoli, Joseph, Lombardo, Louis J.
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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Journal Article
Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1- f][1,2,4]triazine based VEGFR-2 kinase inhibitors
Borzilleri, Robert M., Cai, Zhen-wei, Ellis, Christopher, Fargnoli, Joseph, Fura, Aberra, Gerhardt, Tracy, Goyal, Bindu, Hunt, John T., Mortillo, Steven, Qian, Ligang, Tokarski, John, Vyas, Viral, Wautlet, Barri, Zheng, Xioping, Bhide, Rajeev S.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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