CYP17 inhibitors for prostate cancer therapy
Vasaitis, Tadas S., Bruno, Robert D., Njar, Vincent C.O.
Published in The Journal of steroid biochemistry and molecular biology (01.05.2011)
Published in The Journal of steroid biochemistry and molecular biology (01.05.2011)
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Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation
dos Santos, Diandra Zipinotti, Elbaz, Mohamad, Branchard, Emily, Schormann, Wiebke, Brown, Carla E., Meek, Autumn R., Njar, Vincent C.O., Hamilton, Robert J., Reed, Mark A., Andrews, David W., Penn, Linda Z.
Published in Biomedicine & pharmacotherapy (01.08.2024)
Published in Biomedicine & pharmacotherapy (01.08.2024)
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Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
Vasaitis, Tadas, Belosay, Aashvini, Schayowitz, Adam, Khandelwal, Aakanksha, Chopra, Pankaj, Gediya, Lalji K., Guo, Zhiyong, Fang, Hong-Bin, Njar, Vincent C.O., Brodie, Angela M.H.
Published in Molecular cancer therapeutics (01.08.2008)
Published in Molecular cancer therapeutics (01.08.2008)
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Journal Article
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo
Maranto, Cristina, Udhane, Vindhya, Jia, Jing, Verma, Ranjit, Müller-Newen, Gerhard, LaViolette, Peter S, Pereckas, Michael, Sabharwal, Lavannya, Terhune, Scott, Pattabiraman, Nagarajan, Njar, Vincent C O, Imig, John D, Wang, Liang, Nevalainen, Marja T
Published in Cancers (18.11.2020)
Published in Cancers (18.11.2020)
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Journal Article
17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
Bruno, Robert D., Gover, Tony D., Burger, Angelika M., Brodie, Angela M., Njar, Vincent C.O.
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Journal Article
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases
Njar, Vincent C.O., Gediya, Lalji, Purushottamachar, Puranik, Chopra, Pankaj, Vasaitis, Tadas Sean, Khandelwal, Aakanksha, Mehta, Jhalak, Huynh, Carlic, Belosay, Aashvini, Patel, Jyoti
Published in Bioorganic & medicinal chemistry (01.07.2006)
Published in Bioorganic & medicinal chemistry (01.07.2006)
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Journal Article
Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells, and tumor xenografts
Godbole, Abhijit M, Purushottamachar, Puranik, Martin, Marlena S, Daskalakis, Constantine, Njar, Vincent C O
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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Journal Article
Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro
Schayowitz, Adam, Sabnis, Gauri, Njar, Vincent C O, Brodie, Angela M H
Published in Molecular cancer therapeutics (01.01.2008)
Published in Molecular cancer therapeutics (01.01.2008)
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Journal Article
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Moreira, Vânia M.A., Vasaitis, Tadas S., Njar, Vincent C.O., Salvador, Jorge A.R.
Published in Steroids (01.12.2007)
Published in Steroids (01.12.2007)
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Journal Article
Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus
Goss, Paul E., Qi, Shangle, Hu, Haiqing, Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Njar, Vincent C. O.
Published in Breast cancer research and treatment (01.05.2012)
Published in Breast cancer research and treatment (01.05.2012)
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Journal Article
Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications
Brodie, Angela M.H, Njar, Vincent C.O
Published in Journal of Steroid Biochemistry and Molecular Biology (01.07.1998)
Published in Journal of Steroid Biochemistry and Molecular Biology (01.07.1998)
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Book Review
Journal Article
Abstract LBA027: Mechanistic insights on the effects of the lead next generation galeterone analog, VNPP433-3β in castration resistant prostate cancer
Thomas, Elizabeth, Thankan, Retheesh S, Purushottamachar, Puranik, Njar, Vincent C.O.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice
Purushottamachar, Puranik, Thomas, Elizabeth, Thankan, Retheesh S., Njar, Vincent C.O.
Published in European journal of medicinal chemistry (05.08.2022)
Published in European journal of medicinal chemistry (05.08.2022)
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Journal Article
Abstract B004: Dealing with prostate cancer racial disparity: Galeterone and next-generation galeterone analog VNPP433-3β potently inhibits proliferation of prostate cancer cells from African American patient by degrading AR and Mnk1/2
Thomas, Elizabeth, Thankan, Retheesh Sulochana, Purushottachar, Puranik, Njar, Vincent C.O.
Published in Cancer epidemiology, biomarkers & prevention (01.12.2023)
Published in Cancer epidemiology, biomarkers & prevention (01.12.2023)
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Journal Article
Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal transition and stem cell markers
Thomas, Elizabeth, Thankan, Retheesh S., Purushottamachar, Puranik, Huang, Weiliang, Kane, Maureen A., Zhang, Yuji, Ambulos, Nicholas, Weber, David J., Njar, Vincent C. O.
Published in Molecular carcinogenesis (01.07.2022)
Published in Molecular carcinogenesis (01.07.2022)
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