Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues
Liu, Peng, Roberts, Sophie, Shoemaker, James T, Vukasinovic, Jelena, Tomlinson, Darren C, Speirs, Valerie
Published in PloS one (16.03.2023)
Published in PloS one (16.03.2023)
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High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers
Martin, Heather L, Adams, Matthew, Higgins, Julie, Bond, Jacquelyn, Morrison, Ewan E, Bell, Sandra M, Warriner, Stuart, Nelson, Adam, Tomlinson, Darren C
Published in PloS one (05.02.2014)
Published in PloS one (05.02.2014)
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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Haza, Katarzyna Z., Martin, Heather L., Rao, Ajinkya, Turner, Amy L., Saunders, Sophie E., Petersen, Britta, Tiede, Christian, Tipping, Kevin, Tang, Anna A., Ajayi, Modupe, Taylor, Thomas, Harvey, Maia, Fishwick, Keri M., Adams, Thomas L., Gaule, Thembaninkosi G., Trinh, Chi H., Johnson, Matthew, Breeze, Alexander L., Edwards, Thomas A., McPherson, Michael J., Tomlinson, Darren C.
Published in Nature communications (30.06.2021)
Published in Nature communications (30.06.2021)
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Selection and characterisation of Affimers specific for CEA recognition
Shamsuddin, Shazana Hilda, Jayne, David G., Tomlinson, Darren C., McPherson, Michael J., Millner, Paul A.
Published in Scientific reports (12.01.2021)
Published in Scientific reports (12.01.2021)
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Journal Article
Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk
King, Rhodri J, Schuett, Katharina, Tiede, Christian, Jankowski, Vera, John, Vicky, Trehan, Abhi, Simmons, Katie, Ponnambalam, Sreenivasan, Storey, Robert F, Fishwick, Colin WG, McPherson, Michael J, Tomlinson, Darren C, Ajjan, Ramzi A
Published in Haematologica (Roma) (01.06.2021)
Published in Haematologica (Roma) (01.06.2021)
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Journal Article
The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
Smith, Gina A, Fearnley, Gareth W, Tomlinson, Darren C, Harrison, Michael A, Ponnambalam, Sreenivasan
Published in Bioscience reports (01.10.2015)
Published in Bioscience reports (01.10.2015)
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Affimers as anti-idiotypic affinity reagents for pharmacokinetic analysis of biotherapeutics
Adamson, Hope, Nicholl, Amanda, Tiede, Christian, Tang, Anna A, Davidson, Alex, Curd, Helen, Wignall, Alex, Ford, Robert, Nuttall, James, McPherson, Michael J, Johnson, Matt, Tomlinson, Darren C
Published in BioTechniques (01.12.2019)
Published in BioTechniques (01.12.2019)
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Journal Article
Fibroblast Growth Factor Receptor 1 Promotes Proliferation and Survival via Activation of the Mitogen-Activated Protein Kinase Pathway in Bladder Cancer
TOMLINSON, Darren C, LAMONT, Fiona R, SHNYDER, Steve D, KNOWLES, Margaret A
Published in Cancer research (Chicago, Ill.) (01.06.2009)
Published in Cancer research (Chicago, Ill.) (01.06.2009)
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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology
Hughes, David J, Tiede, Christian, Penswick, Natalie, Tang, Anna Ah-San, Trinh, Chi H, Mandal, Upasana, Zajac, Katarzyna Z, Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A, Duan, Jianxin, Feyfant, Eric, McPherson, Michael J, Tomlinson, Darren C, Whitehouse, Adrian
Published in Science signaling (14.11.2017)
Published in Science signaling (14.11.2017)
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Journal Article
FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms
Tomlinson, Darren C, Baxter, Euan W, Loadman, Paul M, Hull, Mark A, Knowles, Margaret A
Published in PloS one (12.06.2012)
Published in PloS one (12.06.2012)
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Journal Article
Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
Martin, Heather L., Turner, Amy L., Higgins, Julie, Tang, Anna A., Tiede, Christian, Taylor, Thomas, Siripanthong, Sitthinon, Adams, Thomas L., Manfield, Iain W., Bell, Sandra M., Morrison, Ewan E., Bond, Jacquelyn, Trinh, Chi H., Hurst, Carolyn D., Knowles, Margaret A., Bayliss, Richard W., Tomlinson, Darren C.
Published in Cell reports (Cambridge) (31.10.2023)
Published in Cell reports (Cambridge) (31.10.2023)
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Journal Article
A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges
di Martino, Erica, Tomlinson, Darren C., Knowles, Margaret A.
Published in Advances in Urology (01.01.2012)
Published in Advances in Urology (01.01.2012)
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Journal Article
Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications
Kearney, Katherine J., Pechlivani, Nikoletta, King, Rhodri, Tiede, Christian, Phoenix, Fladia, Cheah, Ramsah, Macrae, Fraser L., Simmons, Katie J., Manfield, Iain W., Smith, Kerrie A., Spurgeon, Benjamin E.J., Naseem, Khalid M., Ariens, Robert A.S., McPherson, Michael J., Tomlinson, Darren C., Ajjan, Ramzi A.
Published in Blood (14.03.2019)
Published in Blood (14.03.2019)
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Journal Article
VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8
Smith, Gina A., Fearnley, Gareth W., Abdul‐Zani, Izma, Wheatcroft, Stephen B., Tomlinson, Darren C., Harrison, Michael A., Ponnambalam, Sreenivasan
Published in Traffic (Copenhagen, Denmark) (01.01.2016)
Published in Traffic (Copenhagen, Denmark) (01.01.2016)
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Journal Article
FGFR3 and ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma
JEBAR, Adel H, HURST, Carolyn D, TOMLINSON, Darren C, JOHNSTON, Colin, TAYLOR, Claire F, KNOWLES, Margaret A
Published in Oncogene (04.08.2005)
Published in Oncogene (04.08.2005)
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Journal Article
Affimer reagents as tools in diagnosing plant virus diseases
Hesketh, Emma L., Tiede, Christian, Adamson, Hope, Adams, Thomas L., Byrne, Matthew J., Meshcheriakova, Yulia, Kruse, Inga, McPherson, Michael J., Lomonossoff, George P., Tomlinson, Darren C., Ranson, Neil A.
Published in Scientific reports (17.05.2019)
Published in Scientific reports (17.05.2019)
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Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis
Rawlings, Andrea E, Bramble, Jonathan P, Tang, Anna A S, Somner, Lori A, Monnington, Amy E, Cooke, David J, McPherson, Michael J, Tomlinson, Darren C, Staniland, Sarah S
Published in Chemical science (Cambridge) (01.10.2015)
Published in Chemical science (Cambridge) (01.10.2015)
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Alternative reagents to antibodies in imaging applications
Bedford, R., Tiede, C., Hughes, R., Curd, A., McPherson, M. J., Peckham, Michelle, Tomlinson, Darren C.
Published in Biophysical reviews (01.08.2017)
Published in Biophysical reviews (01.08.2017)
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