In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
Roeloffs, Rosemarie, Wickenden, Alan D, Crean, Christopher, Werness, Stephen, McNaughton-Smith, Grant, Stables, James, McNamara, James O, Ghodadra, Neil, Rigdon, Greg C
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis
Aleo, Michael D., Aubrecht, Jiri, D. Bonin, Paul, Burt, Deborah A., Colangelo, Jennifer, Luo, Lina, Schomaker, Shelli, Swiss, Rachel, Kirby, Simon, C. Rigdon, Greg, Dua, Pinky
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia
Ataga, Kenneth I., Smith, Wally R., De Castro, Laura M., Swerdlow, Paul, Saunthararajah, Yogen, Castro, Oswaldo, Vichinsky, Elliot, Kutlar, Abdullah, Orringer, Eugene P., Rigdon, Greg C., Stocker, Jonathan W.
Published in Blood (15.04.2008)
Published in Blood (15.04.2008)
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Kv7 potassium channel activation with ICA‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy
Kasteleijn‐Nolst Trenité, Dorotheé G. A., Biton, Victor, French, Jacqueline A., Abou‐Khalil, Bassel, Rosenfeld, William E., Diventura, Bree, Moore, Elizabeth L., Hetherington, Seth V., Rigdon, Greg C.
Published in Epilepsia (Copenhagen) (01.08.2013)
Published in Epilepsia (Copenhagen) (01.08.2013)
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Anti‐haemolytic effect of senicapoc and decrease in NT‐proBNP in adults with sickle cell anaemia
Minniti, Caterina P., Wilson, Jonathan, Mendelsohn, Laurel, Rigdon, Greg C., Stocker, Jonathan W., Remaley, Alan T., Kato, Gregory J.
Published in British journal of haematology (01.12.2011)
Published in British journal of haematology (01.12.2011)
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N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy
Amato, George, Roeloffs, Rosemarie, Rigdon, Greg C, Antonio, Brett, Mersch, Theresa, McNaughton-Smith, Grant, Wickenden, Alan D, Fritch, Paul, Suto, Mark J
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
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Indanylidenes. 1. Design and Synthesis of (E)-2-(4,6-Difluoro-1-indanylidene)acetamide, a Potent, Centrally Acting Muscle Relaxant with Antiinflammatory and Analgesic Activity
Musso, David L, Cochran, Felicia R, Kelley, James L, McLean, Ed W, Selph, Jeffrey L, Rigdon, Greg C, Orr, G. Faye, Davis, Ronda G, Cooper, Barrett R, Styles, Virgil L, Thompson, James B, Hall, William R
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
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Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity
Musso, David L, Orr, G. Faye, Cochran, Felicia R, Kelley, James L, Selph, Jeffrey L, Rigdon, Greg C, Cooper, Barrett R, Jones, Michael L
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
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Synthesis and Evaluation of Heterocyclic Carboxamides as Potential Antipsychotic Agents
Norman, Mark H, Navas, Frank, Thompson, James B, Rigdon, Greg C
Published in Journal of medicinal chemistry (22.11.1996)
Published in Journal of medicinal chemistry (22.11.1996)
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K v7 potassium channel activation with ICA ‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy
Kasteleijn‐Nolst Trenité, Dorotheé G. A., Biton, Victor, French, Jacqueline A., Abou‐Khalil, Bassel, Rosenfeld, William E., Diventura, Bree, Moore, Elizabeth L., Hetherington, Seth V., Rigdon, Greg C.
Published in Epilepsia (Copenhagen) (01.08.2013)
Published in Epilepsia (Copenhagen) (01.08.2013)
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Variations in the Use of Transcranial Doppler and Chronic Transfusion Therapy for Stroke Prevention in Pediatric Populations at Sickle Cell Centers
Mulberg, Andrew E., Behm, Martin, Magia, Catherine, Adams, Robert, Drachtman, Richard, Rigdon, Greg C.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Commentary
JOINER, Clinton H, ATAGA, Kenneth I, RIGDON, Greg C, STOCKER, Jonathan W, SMITH, Wally R, DE CASTRO, Laura M, SWERDLOW, Paul, SAUNTHARARAJAH, Yogen, CASTRO, Oswaldo, VICHINSKY, Elliot, KUTLAR, Abdullah, ORRINGER, Eugene P
Published in Blood (2008)
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Published in Blood (2008)
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Is clozapine selective for the dopamine D 4 receptor?
Durcan, Michael J., Rigdon, Greg C., Norman, Mark H., Morgan, Philip F.
Published in Life sciences (1973) (22.09.1995)
Published in Life sciences (1973) (22.09.1995)
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1192U90 in animal tests that predict antipsychotic efficacy, anxiolysis, and extrapyramidal side effects
Rigdon, Greg C., Norman, Mark H., Cooper, Barrett R., Howard, James L., Boncek, Virginia M., Faison, Walter L., Nanry, Kevin P., Pollard, Gerald T.
Published in Neuropsychopharmacology (New York, N.Y.) (01.09.1996)
Published in Neuropsychopharmacology (New York, N.Y.) (01.09.1996)
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