The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins
Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Published in The Journal of cell biology (19.07.2004)
Published in The Journal of cell biology (19.07.2004)
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Journal Article
Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress
Maccario, Helene, Perera, Nevin M., Gray, Alexander, Downes, C. Peter, Leslie, Nick R.
Published in The Journal of biological chemistry (23.04.2010)
Published in The Journal of biological chemistry (23.04.2010)
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Journal Article
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan MF
Published in The EMBO journal (13.10.2004)
Published in The EMBO journal (13.10.2004)
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Journal Article
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
Thomas, George, Radimerski, Thomas, Montagne, Jacques, Rintelen, Felix, Stocker, Hugo, van der Kaay, Jeroen, Downes, C. Peter, Hafen, Ernst
Published in Nature cell biology (01.03.2002)
Published in Nature cell biology (01.03.2002)
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Journal Article
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
Gray, Alexander, Olsson, Henric, Batty, Ian H, Priganica, Larisa, Peter Downes, C
Published in Analytical biochemistry (15.02.2003)
Published in Analytical biochemistry (15.02.2003)
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Journal Article
The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission
Hill, Elaine, van der Kaay, Jeroen, Downes, C. Peter, Smythe, Elizabeth
Published in The Journal of cell biology (22.01.2001)
Published in The Journal of cell biology (22.01.2001)
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Journal Article
Regulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 Phosphorylation
Nawaratne, Ranmali, Gray, Alexander, Jørgensen, Christina H, Downes, C. Peter, Siddle, Kenneth, Sethi, Jaswinder K
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2006)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2006)
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Journal Article
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2
Batty, Ian H, van der Kaay, Jeroen, Gray, Alex, Telfer, Joan F, Dixon, Miles J, Downes, C Peter
Published in Biochemical journal (15.10.2007)
Published in Biochemical journal (15.10.2007)
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Journal Article
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
James, S R, Downes, C P, Gigg, R, Grove, S J, Holmes, A B, Alessi, D R
Published in Biochemical journal (01.05.1996)
Published in Biochemical journal (01.05.1996)
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Journal Article
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy
Watt, Stephen A, Kimber, Wendy A, Fleming, Ian N, Leslie, Nick R, Downes, C Peter, Lucocq, John M
Published in Biochemical journal (01.02.2004)
Published in Biochemical journal (01.02.2004)
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Journal Article
Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface
Bentley, Johanne, Itchayanan, Dalina, Barnes, Kay, McIntosh, Elizabeth, Tang, Xiuwen, Downes, C.Peter, Holman, Geoffrey D., Whetton, Anthony D., Owen-Lynch, P.Jane, Baldwin, Stephen A.
Published in The Journal of biological chemistry (10.10.2003)
Published in The Journal of biological chemistry (10.10.2003)
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Journal Article
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
Fleming, Ian N, Batty, Ian H, Prescott, Alan R, Gray, Alex, Kular, Gursant S, Stewart, Hazel, Downes, C Peter
Published in Biochemical journal (15.09.2004)
Published in Biochemical journal (15.09.2004)
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Journal Article
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
Leslie, Nick R, Bennett, Deborah, Lindsay, Yvonne E, Stewart, Hazel, Gray, Alex, Downes, C.Peter
Published in The EMBO journal (15.10.2003)
Published in The EMBO journal (15.10.2003)
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Journal Article
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates
Padmanabhan, Usha, Dollins, D Eric, Fridy, Peter C, York, John D, Downes, C Peter
Published in The Journal of biological chemistry (17.04.2009)
Published in The Journal of biological chemistry (17.04.2009)
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Journal Article
Localization of agonist-sensitive PtdIns(3,4,5)P₃ reveals a nuclear pool that is insensitive to PTEN expression
Lindsay, Yvonne, McCoull, David, Davidson, Lindsay, Leslie, Nick R, Fairservice, Alison, Gray, Alex, Lucocq, John, Downes, C. Peter
Published in Journal of cell science (15.12.2006)
Published in Journal of cell science (15.12.2006)
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Journal Article
PTEN is destabilized by phosphorylation on Thr366
Maccario, Helene, Perera, Nevin M, Davidson, Lindsay, Downes, C Peter, Leslie, Nick R
Published in Biochemical journal (01.08.2007)
Published in Biochemical journal (01.08.2007)
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Journal Article