Host‐directed therapy to combat mycobacterial infections
Kilinç, Gül, Saris, Anno, Ottenhoff, Tom H. M., Haks, Mariëlle C.
Published in Immunological reviews (01.05.2021)
Published in Immunological reviews (01.05.2021)
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Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset
van Meijgaarden, Krista E, Haks, Mariëlle C, Caccamo, Nadia, Dieli, Francesco, Ottenhoff, Tom H M, Joosten, Simone A
Published in PLoS pathogens (01.03.2015)
Published in PLoS pathogens (01.03.2015)
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Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts
Gebremicael, Gebremedhin, Kassa, Desta, Alemayehu, Yodit, Gebreegziaxier, Atsbeha, Kassahun, Yonas, van Baarle, Debbie, H M Ottenhoff, Tom, M Cliff, Jacqueline, C Haks, Mariëlle
Published in PloS one (10.12.2019)
Published in PloS one (10.12.2019)
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A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa
Huttner, Angela, Combescure, Christophe, Grillet, Stéphane, Haks, Mariëlle C, Quinten, Edwin, Modoux, Christine, Agnandji, Selidji Todagbe, Brosnahan, Jessica, Dayer, Julie-Anne, Harandi, Ali M, Kaiser, Laurent, Medaglini, Donata, Monath, Tom, Roux-Lombard, Pascale, Kremsner, Peter G, Ottenhoff, Tom H M, Siegrist, Claire-Anne
Published in Science translational medicine (12.04.2017)
Published in Science translational medicine (12.04.2017)
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Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Korbee, Cornelis J., Heemskerk, Matthias T., Kocev, Dragi, van Strijen, Elisabeth, Rabiee, Omid, Franken, Kees L. M. C., Wilson, Louis, Savage, Nigel D. L., Džeroski, Sašo, Haks, Mariëlle C., Ottenhoff, Tom H. M.
Published in Nature communications (24.01.2018)
Published in Nature communications (24.01.2018)
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Journal Article
Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites
Tran, Tuan M., Bijker, Else M., Haks, Mariëlle C., Ottenhoff, Tom H. M., Visser, Leo, Schats, Remko, Venepally, Pratap, Lorenzi, Hernan, Crompton, Peter D., Sauerwein, Robert W.
Published in Scientific reports (10.06.2019)
Published in Scientific reports (10.06.2019)
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Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics
Vrieling, Frank, Kostidis, Sarantos, Spaink, Herman P., Haks, Mariëlle C., Mayboroda, Oleg A., Ottenhoff, Tom H. M., Joosten, Simone A.
Published in Scientific reports (27.04.2020)
Published in Scientific reports (27.04.2020)
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Journal Article
Blood transcriptional profiles distinguish different clinical stages of cutaneous leishmaniasis in humans
Bahrami, Fariborz, Masoudzadeh, Nasrin, Van Veen, Suzanne, Persson, Josefine, Lari, Arezou, Sarvnaz, Hamzeh, Taslimi, Yasaman, Östensson, Malin, Andersson, Björn, Sharifi, Iraj, Goyonlo, Vahid Mashayekhi, Ottenhoff, Tom HM, Haks, Mariëlle C., Harandi, Ali M., Rafati, Sima
Published in Molecular immunology (01.09.2022)
Published in Molecular immunology (01.09.2022)
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Journal Article
Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
Moreira, Jôsimar D, Koch, Bjørn E V, van Veen, Suzanne, Walburg, Kimberley V, Vrieling, Frank, Mara Pinto Dabés Guimarães, Tânia, Meijer, Annemarie H, Spaink, Herman P, Ottenhoff, Tom H M, Haks, Mariëlle C, Heemskerk, Matthias T
Published in Frontiers in immunology (03.02.2020)
Published in Frontiers in immunology (03.02.2020)
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Host Gene Expression Kinetics During Treatment of Tuberculosis in HIV-Coinfected Individuals Is Independent of Highly Active Antiretroviral Therapy
Gebremicael, Gebremedhin, Kassa, Desta, Quinten, Edwin, Alemayehu, Yodit, Gebreegziaxier, Atsbeha, Belay, Yohannes, van Baarle, Debbie, Ottenhoff, Tom H M, Cliff, Jacqueline M, Haks, Mariëlle C
Published in The Journal of infectious diseases (20.10.2018)
Published in The Journal of infectious diseases (20.10.2018)
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Journal Article
Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis
Boland, Ralf, Heemskerk, Matthias T, Forn-Cuní, Gabriel, Korbee, Cornelis J, Walburg, Kimberley V, Esselink, Jeroen J, Carvalho Dos Santos, Carina, de Waal, Amy M, van der Hoeven, Daniel C M, van der Sar, Elisa, de Ries, Alex S, Xie, Jiajun, Spaink, Herman P, van der Vaart, Michiel, Haks, Mariëlle C, Meijer, Annemarie H, Ottenhoff, Tom H M
Published in mBio (28.02.2023)
Published in mBio (28.02.2023)
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Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites
Schats, Remko, Bijker, Else M, van Gemert, Geert-Jan, Graumans, Wouter, van de Vegte-Bolmer, Marga, van Lieshout, Lisette, Haks, Mariëlle C, Hermsen, Cornelus C, Scholzen, Anja, Visser, Leo G, Sauerwein, Robert W
Published in PloS one (01.05.2015)
Published in PloS one (01.05.2015)
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Stratification of COVID-19 patients based on quantitative immune-related gene expression in whole blood
Persson, Josefine, Andersson, Björn, van Veen, Suzanne, Haks, Mariëlle C., Obudulu, Ogonna, Torkzadeh, Sara, Ottenhoff, Tom H.M., Kanberg, Nelly, Gisslén, Magnus, Andersson, Lars-Magnus, Harandi, Ali M.
Published in Molecular immunology (01.05.2022)
Published in Molecular immunology (01.05.2022)
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Journal Article
Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults
Weinberger, Birgit, Haks, Mariëlle C, de Paus, Roelof A, Ottenhoff, Tom H M, Bauer, Tanja, Grubeck-Loebenstein, Beatrix
Published in Frontiers in immunology (15.05.2018)
Published in Frontiers in immunology (15.05.2018)
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Journal Article
Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria
Tran, Tuan M., Jones, Marcus B., Ongoiba, Aissata, Bijker, Else M., Schats, Remko, Venepally, Pratap, Skinner, Jeff, Doumbo, Safiatou, Quinten, Edwin, Visser, Leo G., Whalen, Elizabeth, Presnell, Scott, O’Connell, Elise M., Kayentao, Kassoum, Doumbo, Ogobara K., Chaussabel, Damien, Lorenzi, Hernan, Nutman, Thomas B., Ottenhoff, Tom H. M., Haks, Mariëlle C., Traore, Boubacar, Kirkness, Ewen F., Sauerwein, Robert W., Crompton, Peter D.
Published in Scientific reports (10.08.2016)
Published in Scientific reports (10.08.2016)
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Journal Article
Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy
Kilinç, Gül, Boland, Ralf, Heemskerk, Matthias T, Spaink, Herman P, Haks, Mariëlle C, van der Vaart, Michiel, Ottenhoff, Tom H M, Meijer, Annemarie H, Saris, Anno
Published in Microbiology spectrum (06.08.2024)
Published in Microbiology spectrum (06.08.2024)
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Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts
Gonzalez Dias Carvalho, Patrícia Conceição, Dominguez Crespo Hirata, Thiago, Mano Alves, Leandro Yukio, Moscardini, Isabelle Franco, do Nascimento, Ana Paula Barbosa, Costa-Martins, André G, Sorgi, Sara, Harandi, Ali M, Ferreira, Daniela M, Vianello, Eleonora, Haks, Mariëlle C, Ottenhoff, Tom H M, Santoro, Francesco, Martinez-Murillo, Paola, Huttner, Angela, Siegrist, Claire-Anne, Medaglini, Donata, Nakaya, Helder I
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Journal Article
Retinal Pigment Epithelial Cells Control Early Mycobacterium tuberculosis Infection via Interferon Signaling
La Distia Nora, Rina, Walburg, Kimberley V, van Hagen, P Martin, Swagemakers, Sigrid M A, van der Spek, Peter J, Quinten, Edwin, van Velthoven, Mirjam, Ottenhoff, Tom H M, Dik, Willem A, Haks, Mariëlle C
Published in Investigative ophthalmology & visual science (01.03.2018)
Published in Investigative ophthalmology & visual science (01.03.2018)
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Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition
Mao, Changchuin, Tili, Esmerina G, Dose, Marei, Haks, Marielle C, Bear, Susan E, Maroulakou, Ioanna, Horie, Kyoji, Gaitanaris, George A, Fidanza, Vincenzo, Ludwig, Thomas, Wiest, David L, Gounari, Fotini, Tsichlis, Philip N
Published in Journal of Immunology (01.05.2007)
Published in Journal of Immunology (01.05.2007)
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