Targeting mutant p53 for efficient cancer therapy
Bykov, Vladimir J. N., Eriksson, Sofi E., Bianchi, Julie, Wiman, Klas G.
Published in Nature reviews. Cancer (01.02.2018)
Published in Nature reviews. Cancer (01.02.2018)
Get full text
Journal Article
Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
LEHMANN, Sören, BYKOV, Vladimir J. N, PAUL, Christer, WIMAN, Klas G, ANDERSSON, Per-Ola, ALI, Dina, ANDREN, Ove, CHERIF, Honar, TIDEFELT, Ulf, UGGLA, Bertil, YACHNIN, Jeffrey, JULIUSSON, Gunnar, MOSHFEGH, Ali
Published in Journal of clinical oncology (10.10.2012)
Published in Journal of clinical oncology (10.10.2012)
Get full text
Journal Article
APR-246 reactivates mutant p53 by targeting cysteines 124 and 277
Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Published in Cell death & disease (18.04.2018)
Published in Cell death & disease (18.04.2018)
Get full text
Journal Article
Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene
Palomar-Siles, Mireia, Yurevych, Viktor, Bykov, Vladimir J. N, Wiman, Klas G
Published in PloS one (02.11.2023)
Published in PloS one (02.11.2023)
Get full text
Journal Article
Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246
Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
Published in Scientific reports (23.08.2018)
Published in Scientific reports (23.08.2018)
Get full text
Journal Article
PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
Lambert, Jeremy M.R., Gorzov, Petr, Veprintsev, Dimitry B., Söderqvist, Maja, Segerbäck, Dan, Bergman, Jan, Fersht, Alan R., Hainaut, Pierre, Wiman, Klas G., Bykov, Vladimir J.N.
Published in Cancer cell (05.05.2009)
Published in Cancer cell (05.05.2009)
Get full text
Journal Article
p53 as a hub in cellular redox regulation and therapeutic target in cancer
Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
Published in Journal of molecular cell biology (01.04.2019)
Published in Journal of molecular cell biology (01.04.2019)
Get full text
Journal Article
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
Palomar-Siles, Mireia, Heldin, Angelos, Zhang, Meiqiongzi, Strandgren, Charlotte, Yurevych, Viktor, van Dinter, Jip T., Engels, Sem A. G., Hofman, Damon A., Öhlin, Susanne, Meineke, Birthe, Bykov, Vladimir J. N., van Heesch, Sebastiaan, Wiman, Klas G.
Published in Cell death & disease (25.11.2022)
Published in Cell death & disease (25.11.2022)
Get full text
Journal Article
Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes
Arnljots, Thorsteinn S, Kasina, Rafael, Bykov, Vladimir J N, Economou, Mario A
Published in Journal of glaucoma (01.10.2018)
Published in Journal of glaucoma (01.10.2018)
Get more information
Journal Article
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Published in Cell death & disease (15.07.2021)
Published in Cell death & disease (15.07.2021)
Get full text
Journal Article
Role of Thiol Reactivity for Targeting Mutant p53
Zhang, Qiang, Bergman, Jan, Wiman, Klas G, Bykov, Vladimir J N
Published in Cell chemical biology (18.10.2018)
Published in Cell chemical biology (18.10.2018)
Get full text
Journal Article
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death
Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
Published in EMBO molecular medicine (05.02.2021)
Published in EMBO molecular medicine (05.02.2021)
Get full text
Journal Article
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
Wiman, Klas G, Bykov, Vladimir J.N, Issaeva, Natalia, Shilov, Alexandre, Hultcrantz, Monica, Pugacheva, Elena, Chumakov, Peter, Bergman, Jan, Selivanova, Galina
Published in Nature medicine (01.03.2002)
Published in Nature medicine (01.03.2002)
Get full text
Journal Article
Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide Analogs
Bykov, Vladimir J.N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
Published in The Journal of biological chemistry (26.08.2005)
Published in The Journal of biological chemistry (26.08.2005)
Get full text
Journal Article
Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN
Heldin, Angelos, Cancer, Matko, Palomar-Siles, Mireia, Öhlin, Susanne, Zhang, Meiqiongzi, Sun-Zhang, Alexander, Mariani, Anna, Liu, Jianping, Bykov, Vladimir J.N., Wiman, Klas G.
Published in RNA biology (2023)
Published in RNA biology (2023)
Get full text
Journal Article
Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death
Cheteh, Emarndeena H, Augsten, Martin, Rundqvist, Helene, Bianchi, Julie, Sarne, Victoria, Egevad, Lars, Bykov, Vladimir JN, Östman, Arne, Wiman, Klas G
Published in Cell death & disease (01.06.2017)
Published in Cell death & disease (01.06.2017)
Get full text
Journal Article
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs
Bykov, Vladimir J.N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
Published in The Journal of biological chemistry (01.12.2017)
Published in The Journal of biological chemistry (01.12.2017)
Get full text
Journal Article