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Published in mBio (14.04.2022)
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Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226
Ke, Wei, Bethel, Christopher R, Papp-Wallace, Krisztina M, Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D, Bonomo, Robert A, van den Akker, Focco
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Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies
Zhu, Dunming, Yang, Yan, Buynak, John D, Hua, Ling
Published in Organic & biomolecular chemistry (01.01.2006)
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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3
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Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp
Lasarte-Monterrubio, Cristina, Vázquez-Ucha, Juan C, Maneiro, Maria, Arca-Suárez, Jorge, Alonso, Isaac, Guijarro-Sánchez, Paula, Buynak, John D, Bou, Germán, González-Bello, Concepción, Beceiro, Alejandro
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Triethysilyl enol ethers in the synthesis of carbapenem precursors
Nguyen, Thu Q., Chai, Weirui, Gu, Jane, Cook, Katie, Kim, Eugene, Goetz, Sam, Farni, Zach, Chepuru, Monica, Cox, Melina, Nguyen, Pauline, Raja, Hashim, Magistrado, Patrick, Michael, Faith, Oelschlaeger, Peter, Buynak, John D.
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition
Rodkey, Elizabeth A, Winkler, Marisa L, Bethel, Christopher R, Pagadala, Sundar Ram Reddy, Buynak, John D, Bonomo, Robert A, van den Akker, Focco
Published in PloS one (2014)
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Penicillin Sulfone Inhibitors of Class D β-Lactamases
DRAWZ, Sarah M, BETHEL, Christopher R, BONOMO, Robert A, DOPPALAPUDI, Venkata R, SHERI, Anjaneyulu, SUNDAR RAM REDDY PAGADALA, HUJER, Andrea M, SKALWEIT, Marion J, ANDERSON, Vernon E, CHEN, Shu G, BUYNAK, John D
Published in Antimicrobial Agents and Chemotherapy (01.04.2010)
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Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation
Ke, Wei, Pattanaik, Priyaranjan, Bethel, Christopher R, Sheri, Anjaneyulu, Buynak, John D, Bonomo, Robert A, van den Akker, Focco
Published in PloS one (08.11.2012)
Published in PloS one (08.11.2012)
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Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase
SAMPSON, Jared M, WEI KE, BETHEL, Christopher R, PAGADALA, S. R. R, NOTTINGHAM, Michael D, BONOMO, Robert A, BUYNAK, John D, VAN DEN AKKER, Focco
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors
Kang, Joon S, Zhang, Antonia L, Faheem, Mohammad, Zhang, Charles J, Ai, Ni, Buynak, John D, Welsh, William J, Oelschlaeger, Peter
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Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp
BLACK, Jennifer A, THOMSON, Kenneth S, BUYNAK, John D, PITOUT, Johann D. D
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Published in Journal of Clinical Microbiology (01.08.2005)
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Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii
Vázquez-Ucha, Juan Carlos, Martínez-Guitián, Marta, Maneiro, María, Conde-Pérez, Kelly, Álvarez-Fraga, Laura, Torrens, Gabriel, Oliver, Antonio, Buynak, John D, Bonomo, Robert A, Bou, Germán, González-Bello, Concepción, Poza, Margarita, Beceiro, Alejandro
Published in Antimicrobial agents and chemotherapy (01.10.2019)
Published in Antimicrobial agents and chemotherapy (01.10.2019)
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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases
Smith, Clyde A., Stewart, Nichole K., Toth, Marta, Quan, Pojun, Buynak, John D., Vakulenko, Sergei B.
Published in ACS infectious diseases (12.05.2023)
Published in ACS infectious diseases (12.05.2023)
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LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48
Vallejo, Juan A, Martínez-Guitián, Marta, Vázquez-Ucha, Juan C, González-Bello, Concepción, Poza, Margarita, Buynak, John D, Bethel, Christopher R, Bonomo, Robert A, Bou, German, Beceiro, Alejandro
Published in Journal of antimicrobial chemotherapy (01.08.2016)
Published in Journal of antimicrobial chemotherapy (01.08.2016)
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Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase
HUJER, Andrea M, KANIA, Malgosia, GERKEN, Thomas, ANDERSON, Vernon E, BUYNAK, John D, XIAOXIA GE, CASPERS, Patrick, PAGE, Malcolm G. P, RICE, Louis B, BONOMO, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.02.2005)
Published in Antimicrobial Agents and Chemotherapy (01.02.2005)
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